scholarly journals Induction chemotherapy with concurrent chemoradiotherapy versus concurrent chemoradiotherapy for locally advanced squamous cell carcinoma of head and neck: a meta-analysis

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Lijuan Zhang ◽  
Nan Jiang ◽  
Yuexian Shi ◽  
Shipeng Li ◽  
Peiguo Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Squamous Cell ◽  
Concurrent Chemoradiotherapy ◽  
Meta Analysis ◽  
Locally Advanced ◽  
Advanced Squamous Cell Carcinoma

scholarly journals Induction Chemotherapy Followed by Radiotherapy Versus Induction Chemotherapy Followed by Chemoradiotherapy in Locally Advanced Squamous Cell Carcinoma of Head and Neck

KYAMC Journal ◽  
2019 ◽  
Vol 10 (3) ◽  
pp. 128-132
Author(s):  
Md Nazmul Alam ◽  
Md Abdul Bari ◽  
Sarwar Alam ◽  
Md Shahidul Islam ◽  
Tanvir Ahmed
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Squamous Cell ◽  
Concurrent Chemoradiotherapy ◽  
Locally Advanced ◽  
Advanced Squamous Cell Carcinoma ◽  
Radiotherapy Alone ◽  
Grade 3

Background: Radiotherapy and chemotherapy are practiced widely for the treatment of locally advanced squamous cell carcinoma of head and neck Objectives: To compares the effectiveness and toxicities between induction chemotherapy followed by radiotherapy alone and concurrent chemoradiotherapy Materials and Methods: A quasi experimental study was carried out from January 2014 to December 2014. Total sixty patients with locally advanced squamous cell carcinoma of head and neck origin were included and allocated into the arm A and B alternatively. Induction chemotherapy by Cisplatin and 5-Fluorouracil was given to the patient of both arms. Injection Cisplatin was given concurrently during the whole length of radiotherapy period in Arm A while patient in Arm B received radiotherapy alone. The patients were evaluated up to 30 weeks following the completion of the treatment. Results: In this study, male to female ratio was 4:1 and mean age at diagnosis was 60 ± 5 years. Overall complete response was 90% (27/30) and 53.3% (16/30) for the Arm A and Arm B respectively at 30 weeks after completion of treatment. During induction chemotherapy only 5% (3/60) of patients suffered from Grade 3 diarrhoea in both arms. In Arm A Grade 3 and 4 mucositis was observed in 36.66% (11/30) and 3.33% (1/30) of patients respectively whereas in Arm B it was 33.33% (10/30) and 3.33% (1/30) respectively. Conclusion: Induction chemotherapy followed by concurrent chemoradiotherapy is more effective than induction chemotherapy followed by radiotherapy alone in loco-regional control of locally advanced squamous cell carcinoma ofhead and neck origin KYAMC Journal Vol. 10, No.-3, October 2019, Page 128-132

scholarly journals Outcome of Concurrent Chemoradiotherapy and Radiotherapy Alone Following Induction Chemotherapy in Locally Advanced Squamous Cell Carcinoma of Head and Neck

2018 ◽  
Vol 44 (2) ◽  
pp. 93-97
Author(s):  
Md. Abdul Bari ◽  
Sarwar Alam ◽  
Sadia Sharmin ◽  
Shamsun Nahar ◽  
Jamal Uddin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Squamous Cell ◽  
Concurrent Chemoradiotherapy ◽  
Locally Advanced ◽  
Advanced Squamous Cell Carcinoma ◽  
Female Ratio ◽  
Radiotherapy Alone

Non-operative treatment strategies like radiotherapy and chemotherapy are practiced widely nowadays for the treatment of locally advanced squamous cell carcinoma of head and neck origin. Aim of this study was to compare the response of induction chemotherapy followed by radiotherapy alone with induction chemotherapy followed by concurrent chemoradiotherapy in terms of treatment response and toxicities. A quasi-experimental study was carried out in the Department of Radiation Oncology, National Institute of Cancer Research and Hospital (NICR&H), Dhaka; Department of Radiotherapy, Dhaka Medical College Hospital (DMCH), Dhaka and Department of Oncology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka during the period of January, 2014 to December, 2014. Induction chemotherapy by Cisplatin and 5-Fluorouracil was given to all the patients of Arm A and Arm B. Cisplatin was given concurrently during Radiotherapy weekly in case of Arm A. Arm B received radiotherapy alone. The patients were evaluated from the beginning of the treatment up to six months following the completion of treatment. In this study, male to female ratio was 4:1 and mean age of patients were 54.7±9.1 and 56.6±7.9 in Arm A and Arm B respectively. At final follow-up, complete response was seen in 27 (53.3%) patients of Arm A and Arm B respectively. Response rate was significant (p <0.05) for both the Arms. Acute toxicities observed during induction chemotherapy were almost equal in both the Arms, but during radiotherapy, Arm A had more toxicity though it was statistically insignificant. Induction chemotherapy followed by concurrent chemoradiotherapy is more effective than induction chemotherapy followed by radiotherapy alone in loco-regional control of locally advanced squamous cell carcinoma of head and neck origin.

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