scholarly journals A RP-UFLC Assay for Protein Tyrosine Phosphatases: Focus on Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2)

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Romain Duval ◽  
Linh-Chi Bui ◽  
Jérémy Berthelet ◽  
Julien Dairou ◽  
Cécile Mathieu ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatases ◽  
Receptor Type ◽  
Tyrosine Phosphatases ◽  
Protein Tyrosine

scholarly journals Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance

2020 ◽  
Vol 11 ◽  
Author(s):  
Larissa Hering ◽  
Egle Katkeviciute ◽  
Marlene Schwarzfischer ◽  
Philipp Busenhart ◽  
Claudia Gottier ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Protein Tyrosine

scholarly journals The Clinical Relevance of the IBD-Associated Variation within the Risk Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 2 in Patients of the Swiss IBD Cohort

Digestion ◽  
2016 ◽  
Vol 93 (3) ◽  
pp. 182-192 ◽  
Author(s):  
Marianne R. Spalinger ◽  
Marius Voegelin ◽  
Luc Biedermann ◽  
Jonas Zeitz ◽  
Jean-Benoit Rossel ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Clinical Relevance ◽  
Gene Locus ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Protein Tyrosine ◽  
Risk Gene ◽  
Encoding Protein

Tu1740 Matriptase-1 Modulation of Claudin-2 Is Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2) Dependent

2013 ◽  
Vol 144 (5) ◽  
pp. S-834
Author(s):  
Ronald R. Marchelletta ◽  
Taylaur W Smith ◽  
Jessica A. Bañuelos ◽  
Carli Smith ◽  
Brian Houng ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Protein Tyrosine

Protein Tyrosine Phosphatase Non-Receptor Type 2 Regulates NLRP3 Inflammasome Activation

2011 ◽  
Vol 140 (5) ◽  
pp. S-633
Author(s):  
Helen M. Becker ◽  
Barbara Schnell ◽  
Joba M. Arikkat ◽  
Markus Schuppler ◽  
Martin J. Loessner ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Nlrp3 Inflammasome ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Inflammasome Activation ◽  
Protein Tyrosine ◽  
Nlrp3 Inflammasome Activation

scholarly journals Activation of Protein Tyrosine Phosphatase Non-Receptor Type 2 by Spermidine Exerts Anti-Inflammatory Effects in Human THP-1 Monocytes and in a Mouse Model of Acute Colitis

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e73703 ◽  
Author(s):  
Belén Morón ◽  
Marianne Spalinger ◽  
Stephanie Kasper ◽  
Kirstin Atrott ◽  
Isabelle Frey-Wagner ◽  
...  
Keyword(s):  
Mouse Model ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Acute Colitis ◽  
Protein Tyrosine ◽  
Anti Inflammatory

scholarly journals Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

1992 ◽  
Vol 12 (2) ◽  
pp. 836-846 ◽  
Author(s):  
T L Yi ◽  
J L Cleveland ◽  
J N Ihle
Keyword(s):  
Tyrosine Phosphorylation ◽  
Protein Tyrosine Phosphatase ◽  
Human Gene ◽  
Tyrosine Phosphatase ◽  
Hematopoietic Cells ◽  
Protein Tyrosine Phosphatases ◽  
Hematopoietic Cell ◽  
Protein Tyrosine Phosphorylation ◽  
Tyrosine Phosphatases ◽  
Protein Tyrosine

Protein tyrosine phosphorylation has been implicated in the growth and functional responses of hematopoietic cells. Recently, approaches have been developed to characterize the protein tyrosine phosphatases that may contribute to regulation of protein tyrosine phosphorylation. One novel protein tyrosine phosphatase was expressed predominantly in hematopoietic cells. Hematopoietic cell phosphatase encodes a 68-kDa protein that contains a single phosphatase conserved domain. Unlike other known protein tyrosine phosphatases, hematopoietic cell phosphatase contains two src homology 2 domains. We also cloned the human homolog, which has 95% amino acid sequence identity. Both the murine and human gene products have tyrosine-specific phosphatase activity, and both are expressed predominantly in hematopoietic cells. Importantly, the human gene maps to chromosome 12 region p12-p13. This region is associated with rearrangements in approximately 10% of cases of acute lymphocytic leukemia in children.

scholarly journals Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells

2021 ◽  
Vol 12 ◽  
Author(s):  
Feiling Xie ◽  
Hongmei Dong ◽  
Hao Zhang
Keyword(s):  
T Cells ◽  
B Cells ◽  
Immune Cells ◽  
Protein Tyrosine Phosphatase ◽  
Molecular Mechanisms ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatases ◽  
Receptor Type ◽  
Protein Tyrosine ◽  
Cellular Processes

The members of the protein tyrosine phosphatase (PTP) family are key regulators in multiple signal transduction pathways and therefore they play important roles in many cellular processes, including immune response. As a member of PTP family, protein tyrosine phosphatase receptor type O (PTPRO) belongs to the R3 receptor-like protein tyrosine phosphatases. The expression of PTPRO isoforms is tissue-specific and the truncated PTPRO (PTPROt) is mainly observed in hematopoietic cells, including B cells, T cells, macrophages and other immune cells. Therefore, PTPROt may play an important role in immune cells by affecting their growth, differentiation, activation and immune responses. In this review, we will focus on the regulatory roles and underlying molecular mechanisms of PTPRO/PTPROt in immune cells, including B cells, T cells, and macrophages.

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