scholarly journals Quercetin Attenuates Lactate Production and Extracellular Matrix Secretion in Keratoconus

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
T. B. McKay ◽  
D. Lyon ◽  
A. Sarker-Nag ◽  
S. Priyadarsini ◽  
J. M. Asara ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Lactate Production ◽  
Extracellular Matrix Secretion

scholarly journals Effect of bradykinin on renal mesangial cell proliferation and extracellular matrix secretion

2014 ◽  
Vol 13 (1) ◽  
pp. 490-498 ◽  
Author(s):  
C.Y. Liu ◽  
L.L. Zhou ◽  
Q. Cheng ◽  
S.N. Jiang ◽  
J. Sheng ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Proliferation ◽  
Mesangial Cell ◽  
Mesangial Cell Proliferation ◽  
Extracellular Matrix Secretion

scholarly journals Calcium Sensing Receptor Promotes Cardiac Fibroblast Proliferation and Extracellular Matrix Secretion

2014 ◽  
Vol 33 (3) ◽  
pp. 557-568 ◽  
Author(s):  
Xinying Zhang ◽  
Tiemin Zhang ◽  
Jichao Wu ◽  
Xiangjing Yu ◽  
Dan Zheng ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cardiac Fibroblast ◽  
Fibroblast Proliferation ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Extracellular Matrix Secretion

Aristoyunnolin H attenuates extracellular matrix secretion in cardiac fibroblasts by inhibiting calcium influx

2016 ◽  
Vol 40 (1) ◽  
pp. 122-130
Author(s):  
Shao-rui Chen ◽  
Wen-ping Zhang ◽  
Jing-mei Bao ◽  
Zhong-bin Cheng ◽  
Sheng Yin
Keyword(s):  
Extracellular Matrix ◽  
Calcium Influx ◽  
Cardiac Fibroblasts ◽  
Extracellular Matrix Secretion

scholarly journals Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase

2015 ◽  
Vol 309 (8) ◽  
pp. L879-L887 ◽  
Author(s):  
J. L. Judge ◽  
K. M. Owens ◽  
S. J. Pollock ◽  
C. F. Woeller ◽  
T. H. Thatcher ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Lactate Dehydrogenase ◽  
Pulmonary Fibrosis ◽  
Ionizing Radiation ◽  
Lactate Production ◽  
Lung Fibroblasts ◽  
Myofibroblast Differentiation ◽  
Dependent Manner ◽  
Fibrotic Process ◽  
Radiation Induced

Pulmonary fibrosis is a common and dose-limiting side-effect of ionizing radiation used to treat cancers of the thoracic region. Few effective therapies are available for this disease. Pulmonary fibrosis is characterized by an accumulation of myofibroblasts and excess deposition of extracellular matrix proteins. Although prior studies have reported that ionizing radiation induces fibroblast to myofibroblast differentiation and collagen production, the mechanism remains unclear. Transforming growth factor-β (TGF-β) is a key profibrotic cytokine that drives myofibroblast differentiation and extracellular matrix production. However, its activation and precise role in radiation-induced fibrosis are poorly understood. Recently, we reported that lactate activates latent TGF-β through a pH-dependent mechanism. Here, we wanted to test the hypothesis that ionizing radiation leads to excessive lactate production via expression of the enzyme lactate dehydrogenase-A (LDHA) to promote myofibroblast differentiation. We found that LDHA expression is increased in human and animal lung tissue exposed to ionizing radiation. We demonstrate that ionizing radiation induces LDHA, lactate production, and extracellular acidification in primary human lung fibroblasts in a dose-dependent manner. We also demonstrate that genetic and pharmacologic inhibition of LDHA protects against radiation-induced myofibroblast differentiation. Furthermore, LDHA inhibition protects from radiation-induced activation of TGF-β. We propose a profibrotic feed forward loop, in which radiation induces LDHA expression and lactate production, which can lead to further activation of TGF-β to drive the fibrotic process. These studies support the concept of LDHA as an important therapeutic target in radiation-induced pulmonary fibrosis.

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