scholarly journals Nicotinic Acid is a Common Regulator of Heat-Sensing TRPV1-4 Ion Channels

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Linlin Ma ◽  
Bo Hyun Lee ◽  
Heather Clifton ◽  
Saul Schaefer ◽  
Jie Zheng
Keyword(s):  
Ion Channels ◽  
Nicotinic Acid ◽  
Common Regulator

The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP

2013 ◽  
Vol 453 (1) ◽  
pp. 147-151 ◽  
Author(s):  
Dev Churamani ◽  
Robert Hooper ◽  
Taufiq Rahman ◽  
Eugen Brailoiu ◽  
Sandip Patel
Keyword(s):  
Endoplasmic Reticulum ◽  
Ion Channels ◽  
Nicotinic Acid ◽  
Subcellular Location ◽  
Dual Role ◽  
Terminal Region ◽  
Pore Channel ◽  
N Terminus ◽  
And Function ◽  
Acidic Organelles

TPCs (two-pore channels) are NAADP (nicotinic acid–adenine dinucleotide phosphate)-sensitive Ca2+-permeable ion channels expressed on acidic organelles. In the present study we show that deletion of the N-terminal region redirects TPC1 to the ER (endoplasmic reticulum). The introduction of fluorophores at the N-terminus of TPC1 does not affect its subcellular location, but does reversibly abolish NAADP sensitivity. Our results reveal a dual role for the N-terminus in localization and function of TPC1.

Signalling gates in abscisic acid-mediated control of guard cell ion channels

1997 ◽  
Vol 100 (3) ◽  
pp. 481-490 ◽  
Author(s):  
Michael R. Blatt ◽  
Alexander Grabov
Keyword(s):  
Abscisic Acid ◽  
Ion Channels ◽  
Guard Cell

Acid-sensing ion channels

2006 ◽  
pp. S100-S101
Author(s):  
S P H Alexander ◽  
A Mathie ◽  
J A Peters
Keyword(s):  
Ion Channels ◽  
Acid Sensing Ion Channels

Acid Sensing Ion Channels (ASICs) und 5-HT-Rezeptoren bei GERD. Untersuchungen zur Genexpression im pharmakologischen Modell

2015 ◽  
Vol 53 (08) ◽  
Author(s):  
A Shcherbokova ◽  
H Abdel-Aziz ◽  
O Kelber ◽  
K Nieber ◽  
G Ulrich-Merzenich
Keyword(s):  
Ion Channels ◽  
Acid Sensing Ion Channels
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