scholarly journals Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Janahan Arulmoli ◽  
Medha M. Pathak ◽  
Lisa P. McDonnell ◽  
Jamison L. Nourse ◽  
Francesco Tombola ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Neural Stem Cell ◽  
Stem Cell Differentiation ◽  
Dependent Manner ◽  
Static Stretch

Three-dimensional extracellular matrix-mediated neural stem cell differentiation in a microfluidic device

Lab on a Chip ◽  
2012 ◽  
Vol 12 (13) ◽  
pp. 2305 ◽  
Author(s):  
Sewoon Han ◽  
Kisuk Yang ◽  
Yoojin Shin ◽  
Jung Seung Lee ◽  
Roger D. Kamm ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Neural Stem Cell ◽  
Microfluidic Device ◽  
Three Dimensional ◽  
Stem Cell Differentiation

scholarly journals Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation

2015 ◽  
Vol 35 (10) ◽  
pp. 1700-1711 ◽  
Author(s):  
Fenfang Chen ◽  
Xia Lin ◽  
Pinglong Xu ◽  
Zhengmao Zhang ◽  
Yanzhen Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Mesenchymal Stem Cell ◽  
Nuclear Export ◽  
Stem Cell Differentiation ◽  
Bmp Signaling ◽  
Dependent Manner ◽  
Mesenchymal Stem Cell Differentiation

Bone morphogenetic proteins (BMPs) play vital roles in regulating stem cell maintenance and differentiation. BMPs can induce osteogenesis and inhibit myogenesis of mesenchymal stem cells. Canonical BMP signaling is stringently controlled through reversible phosphorylation and nucleocytoplasmic shuttling of Smad1, Smad5, and Smad8 (Smad1/5/8). However, how the nuclear export of Smad1/5/8 is regulated remains unclear. Here we report that the Ran-binding protein RanBP3L acts as a nuclear export factor for Smad1/5/8. RanBP3L directly recognizes dephosphorylated Smad1/5/8 and mediates their nuclear export in a Ran-dependent manner. Increased expression of RanBP3L blocks BMP-induced osteogenesis of mouse bone marrow-derived mesenchymal stem cells and promotes myogenic induction of C2C12 mouse myoblasts, whereas depletion of RanBP3L expression enhances BMP-dependent stem cell differentiation activity and transcriptional responses. In conclusion, our results demonstrate that RanBP3L, as a nuclear exporter for BMP-specific Smads, plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation.

Docosahexaenoic acid controls the expression of Hes1 and p27 on the neural stem cell differentiation

2009 ◽  
Vol 65 ◽  
pp. S90
Author(s):  
Masanori Katakura ◽  
Michio Hashimoto ◽  
Hossain M. Shahdat ◽  
Shyuji Gamoh ◽  
Toshiyuki Okui ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Docosahexaenoic Acid ◽  
Neural Stem Cell ◽  
Stem Cell Differentiation

Expression of Dbn1 during mouse brain development and neural stem cell differentiation

2014 ◽  
Vol 449 (1) ◽  
pp. 81-87 ◽  
Author(s):  
Xiang Ao ◽  
Yunlai Liu ◽  
Maolin Qin ◽  
Chengren Li ◽  
Xingshu Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Brain Development ◽  
Neural Stem Cell ◽  
Mouse Brain ◽  
Stem Cell Differentiation ◽  
Mouse Brain Development
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