scholarly journals Extended Loop Region of Hcp1 is Critical for the Assembly and Function of Type VI Secretion System in Burkholderia pseudomallei

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Yan Ting Lim ◽  
Chacko Jobichen ◽  
Jocelyn Wong ◽  
Direk Limmathurotsakul ◽  
Shaowei Li ◽  
...  
Keyword(s):  
Burkholderia Pseudomallei ◽  
Secretion System ◽  
Type Vi Secretion System ◽  
Loop Region ◽  
Type Vi Secretion ◽  
And Function

scholarly journals The Type VI Secretion System: A Multipurpose Delivery System with a Phage-Like Machinery

2011 ◽  
Vol 24 (7) ◽  
pp. 751-757 ◽  
Author(s):  
Angela R. Records
Keyword(s):  
Plant Growth Promoting Rhizobacteria ◽  
Secretion System ◽  
Host Cells ◽  
Type Vi Secretion System ◽  
Secretion Systems ◽  
Gram Negative ◽  
Extracellular Milieu ◽  
Type Vi Secretion ◽  
Plant Growth Promoting ◽  
And Function

Whether they live in the soil, drift in the ocean, survive in the lungs of human hosts or reside on the surfaces of leaves, all bacteria must cope with an array of environmental stressors. Bacteria have evolved an impressive suite of protein secretion systems that enable their survival in hostile environments and facilitate colonization of eukaryotic hosts. Collectively, gram-negative bacteria produce six distinct secretion systems that deliver proteins to the extracellular milieu or directly into the cytosol of host cells. The type VI secretion system (T6SS) was discovered recently and is encoded in at least one fourth of all sequenced gram-negative bacterial genomes. T6SS proteins are evolutionarily and structurally related to phage proteins, and it is likely that the T6SS apparatus is reminiscent of phage injection machinery. Most studies of T6SS function have been conducted in the context of host-pathogen interactions. However, the totality of data suggests that the T6SS is a versatile tool with roles in virulence, symbiosis, interbacterial interactions, and antipathogenesis. This review gives a brief history of T6SS discovery and an overview of the pathway's predicted structure and function. Special attention is paid to research addressing the T6SS of plant-associated bacteria, including pathogens, symbionts and plant growth–promoting rhizobacteria.

scholarly journals A large lipoprotein mediates target specificity for T6SS-dependent killing

2021 ◽  
Author(s):  
Lauren Speare ◽  
Madison Woo ◽  
Anne K Dunn ◽  
Alecia N Septer
Keyword(s):  
Vibrio Fischeri ◽  
Bacterial Species ◽  
Cell Types ◽  
Secretion System ◽  
Type Vi Secretion System ◽  
Type Vi Secretion ◽  
Host Health ◽  
Specificity Factor ◽  
And Function ◽  
Adhesion Factor

Interbacterial competition is prevalent in host-associated microbiota, where it can shape community structure and function, impacting host health in both positive and negative ways. However, the factors that permit bacteria to discriminate among their various neighbors for targeted elimination of competitors remain elusive. We identified a specificity factor in Vibrio species that is used to target specific competitors for elimination. Here, we describe this specificity factor, which is associated with the broadly-distributed type VI secretion system (T6SS), by studying symbiotic Vibrio fischeri, which use the T6SS to compete for colonization sites in their squid host. We demonstrate that a large lipoprotein (TasL) allows V. fischeri cells to restrict T6SS-dependent killing to certain genotypes by selectively integrating competitor cells into aggregates while excluding other cell types. TasL is also required for T6SS-dependent competition within juvenile squid, indicating the adhesion factor is active in the host. Because TasL homologs are found in other host-associated bacterial species, this newly-described specificity factor has the potential to impact microbiome structure within diverse hosts.

scholarly journals Critical Role of a Sheath Phosphorylation Site On the Assembly and Function of an Atypical Type VI Secretion System

2019 ◽  
Vol 18 (12) ◽  
pp. 2418-2432 ◽  
Author(s):  
Jason Ziveri ◽  
Cerina Chhuon ◽  
Anne Jamet ◽  
Héloïse Rytter ◽  
Guénolé Prigent ◽  
...  
Keyword(s):  
Critical Role ◽  
Phosphorylation Site ◽  
Secretion System ◽  
Type Vi Secretion System ◽  
Type Vi Secretion ◽  
And Function

scholarly journals Clinical impact of the type VI secretion system on virulence of Campylobacter species during infection

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jessica Agnetti ◽  
Helena M. B. Seth-Smith ◽  
Sebastian Ursich ◽  
Josiane Reist ◽  
Marek Basler ◽  
...  
Keyword(s):  
Secretion System ◽  
Clinical Impact ◽  
Type Vi Secretion System ◽  
Type Vi Secretion ◽  
Campylobacter Species
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