scholarly journals First Fatality Associated with Elephant Endotheliotropic Herpesvirus 5 in an Asian Elephant: Pathological Findings and Complete Viral Genome Sequence

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Gavin S. Wilkie ◽  
Andrew J. Davison ◽  
Karen Kerr ◽  
Mark F. Stidworthy ◽  
Sharon Redrobe ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Viral Genome ◽  
Asian Elephant ◽  
Pathological Findings ◽  
Viral Genome Sequence ◽  
Complete Viral Genome

scholarly journals Complete viral genome sequence and discovery of novel viruses by deep sequencing of small RNAs: A generic method for diagnosis, discovery and sequencing of viruses

Virology ◽  
2009 ◽  
Vol 388 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Jan F. Kreuze ◽  
Ana Perez ◽  
Milton Untiveros ◽  
Dora Quispe ◽  
Segundo Fuentes ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Deep Sequencing ◽  
Small Rnas ◽  
Viral Genome ◽  
Viral Genome Sequence ◽  
Complete Viral Genome

scholarly journals Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype

2021 ◽  
Author(s):  
Xiaofeng Dong ◽  
Hannah Goldswain ◽  
Rebekah Penrice-Randal ◽  
Ghada Shawli ◽  
Tessa Prince ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Viral Genome ◽  
Recombinant Virus ◽  
Primate Model ◽  
Large Plaque ◽  
Viral Genome Sequence ◽  
New Variant ◽  
Minor Variant ◽  
Rapid Emergence ◽  
Human Primate

The mutational landscape of SARS-CoV-2 varies at both the dominant viral genome sequence and minor genomic variant population. An early change associated with transmissibility was the D614G substitution in the spike protein. This appeared to be accompanied by a P323L substitution in the viral polymerase (NSP12), but this latter change was not under strong selective pressure. Investigation of P323L/D614G changes in the human population showed rapid emergence during the containment phase and early surge phase of wave 1 in the UK. This rapid substitution was from minor genomic variants to become part of the dominant viral genome sequence. A rapid emergence of 323L but not 614G was observed in a non-human primate model of COVID-19 using a starting virus with P323 and D614 in the dominant genome sequence and 323L and 614G in the minor variant population. In cell culture, a recombinant virus with 323L in NSP12 had a larger plaque size than the same recombinant virus with P323. These data suggest that it may be possible to predict the emergence of a new variant based on tracking the distribution and frequency of minor variant genomes at a population level, rather than just focusing on providing information on the dominant viral genome sequence e.g., consensus level reporting. The ability to predict an emerging variant of SARS-CoV-2 in the global landscape may aid in the evaluation of medical countermeasures and non-pharmaceutical interventions.

Viral tagging reveals discrete populations in Synechococcus viral genome sequence space

Nature ◽  
2014 ◽  
Vol 513 (7517) ◽  
pp. 242-245 ◽  
Author(s):  
Li Deng ◽  
J. Cesar Ignacio-Espinoza ◽  
Ann C. Gregory ◽  
Bonnie T. Poulos ◽  
Joshua S. Weitz ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Sequence Space ◽  
Viral Genome ◽  
Viral Genome Sequence ◽  
Discrete Populations

scholarly journals Two Complete Genome Sequences of Phasey Bean Mild Yellows Virus, a Novel Member of the Luteoviridae from Australia

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Murray Sharman ◽  
Monica Kehoe ◽  
Brenda Coutts ◽  
Joop van Leur ◽  
Fiona Filardo ◽  
...  
Keyword(s):  
Cicer Arietinum ◽  
Genome Sequence ◽  
Viral Genome ◽  
Complete Genome ◽  
Subterranean Clover ◽  
Trifolium Subterraneum ◽  
Genome Sequences ◽  
Viral Genome Sequence ◽  
Macroptilium Lathyroides

We present here the complete genome sequences of a novel polerovirus from Trifolium subterraneum (subterranean clover) and Cicer arietinum (chickpea) and compare these to a partial viral genome sequence obtained from Macroptilium lathyroides (phasey bean). We propose the name phasey bean mild yellows virus for this novel polerovirus.

scholarly journals Transmission dynamics of SARS-CoV-2 on the Diamond Princess uncovered using viral genome sequence analysis

Gene ◽  
2021 ◽  
Vol 779 ◽  
pp. 145496
Author(s):  
Kunikazu Hoshino ◽  
Tatsuji Maeshiro ◽  
Nao Nishida ◽  
Masaya Sugiyama ◽  
Jiro Fujita ◽  
...  
Keyword(s):  
Sequence Analysis ◽  
Genome Sequence ◽  
Viral Genome ◽  
Transmission Dynamics ◽  
Genome Sequence Analysis ◽  
Viral Genome Sequence

scholarly journals Coding-Complete Genome Sequence of a Recombinant Human Norovirus Strain Identified as Subtype GII.p12_GII.3

2020 ◽  
Vol 9 (5) ◽  
Author(s):  
Byung-Joo Park ◽  
Hee-Seop Ahn ◽  
Sang-Hoon Han ◽  
Hyeon-Jeong Go ◽  
Eu-Lim Lyoo ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Acute Gastroenteritis ◽  
Viral Genome ◽  
Complete Genome ◽  
Gc Content ◽  
Open Reading Frames ◽  
Human Norovirus ◽  
Complete Viral Genome ◽  
Reading Frames

A human norovirus (HuNoV) strain was obtained from a patient with acute gastroenteritis, and its complete coding sequence was determined. The coding-complete viral genome, with three open reading frames, was 7,565 bp long, with a GC content of 49.9%. The genotype of the HuNoV strain obtained in this study was identified as GII.p12_GII.3.

Evolution of hepatitis B viral load and viral genome sequence during adefovir dipivoxil therapy

2004 ◽  
Vol 11 (1) ◽  
pp. 74-83 ◽  
Author(s):  
B. Werle ◽  
K. Cinquin ◽  
P. Marcellin ◽  
S. Pol ◽  
M. Maynard ◽  
...  
Keyword(s):  
Viral Load ◽  
Hepatitis B ◽  
Genome Sequence ◽  
Viral Genome ◽  
Adefovir Dipivoxil ◽  
Viral Genome Sequence

scholarly journals Complete Coding Sequence of a Chikungunya Virus Strain Imported into Slovenia from Thailand in Late 2018

2019 ◽  
Vol 8 (37) ◽  
Author(s):  
Samo Zakotnik ◽  
Misa Korva ◽  
Nataša Knap ◽  
Barbara Robnik ◽  
Nina Gorišek Miksić ◽  
...  
Keyword(s):  
Cell Culture ◽  
Phylogenetic Analysis ◽  
Envelope Protein ◽  
Viral Genome ◽  
Chikungunya Virus ◽  
Whole Genome ◽  
Reverse Transcription Pcr ◽  
The Indian Ocean ◽  
Complete Viral Genome ◽  
A226v Mutation

A case of chikungunya virus infection was imported from Thailand into Slovenia in late 2018. The infection was diagnosed using real-time reverse transcription-PCR, the virus was isolated in cell culture, and the whole genome was sequenced. Phylogenetic analysis of the nearly complete viral genome indicated that the virus belongs to the Indian Ocean lineage but does not possess the A226V mutation in the envelope protein E1.

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