scholarly journals Functional tooth restoration by next-generation bio-hybrid implant as a bio-hybrid artificial organ replacement therapy

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Masamitsu Oshima ◽  
Kaoru Inoue ◽  
Kei Nakajima ◽  
Tetsuhiko Tachikawa ◽  
Hiromichi Yamazaki ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Artificial Organ ◽  
Next Generation ◽  
Functional Tooth ◽  
Organ Replacement

scholarly journals Functional ectodermal organ regeneration as the next generation of organ replacement therapy

Open Biology ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 190010 ◽  
Author(s):  
Etsuko Ikeda ◽  
Miho Ogawa ◽  
Makoto Takeo ◽  
Takashi Tsuji
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Replacement Therapy ◽  
Cell Biology ◽  
Three Dimensional ◽  
Great Promise ◽  
Next Generation ◽  
Organ Regeneration ◽  
Size Limitation ◽  
Organ Replacement

In this decade, substantial progress in the fields of developmental biology and stem cell biology has ushered in a new era for three-dimensional organ regenerative therapy. The emergence of novel three-dimensional cell manipulation technologies enables the effective mimicking of embryonic organ germ formation using the fate-determined organ-inductive potential of epithelial and mesenchymal stem cells. This advance shows great potential for the regeneration of functional organs with substitution of complete original function in situ . Organoids generated from multipotent stem cells or tissue stem cells via establishment of an organ-forming field can only partially recover original organ function owing to the size limitation; they are considered ‘mini-organs’. Nevertheless, they hold great promise to realize regenerative medicine. In particular, regeneration of a functional salivary gland and an integumentary organ system by orthotopic and heterotopic implantation of organoids clearly points to the future direction of organ regeneration research. In this review, we describe multiple strategies and recent progress in regenerating functional three-dimensional organs, focusing on ectodermal organs, and discuss their potential and future directions to achieve organ replacement therapy as a next-generation regenerative medicine.

scholarly journals The Impact of Transfer from Hemodialysis on Peritoneal Dialysis Technique Survival

2015 ◽  
Vol 35 (3) ◽  
pp. 297-305 ◽  
Author(s):  
Sharon J. Nessim ◽  
Joanne M. Bargman ◽  
S. Vanita Jassal ◽  
Matthew J. Oliver ◽  
Yingbo Na ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Initial Period ◽  
Significant Proportion ◽  
Secondary Analysis ◽  
First Year ◽  
Technique Survival ◽  
The Impact ◽  
Organ Replacement

BackgroundA significant proportion of peritoneal dialysis (PD) patients receive an initial period of hemodialysis (HD) before transitioning to PD (“PD-switch”). We sought to better understand the risks of PD technique failure (TF) and mortality for those patients compared with patients starting with PD as their first dialysis modality (“PD-first”).MethodsUsing Canadian Organ Replacement Register data, we compared the risk of PD TF between PD-first and PD-switch patients within the first year after HD initiation. In a secondary analysis, the PD-switch patients were stratified into three groups based on timing of the switch from initial HD to PD as follows: 0 – 90 days, 91 – 180 days, and 181 – 365 days. Each group was compared with PD-first patients for risk of PD TF and death.ResultsBetween 2001 and 2010, 9404 patients initiated PD as their first renal replacement therapy, and 3757 switched from HD to PD. After multivariable adjustment, the risk of PD TF was higher among PD-switch patients than among PD-first patients [adjusted hazard ratio (AHR): 1.37; 95% confidence interval (CI): 1.26 to 1.49], particularly within the first year after the switch from HD to PD (AHR: 1.51; 95% CI: 1.36 to 1.68). There was no association between time on HD within the first year and subsequent risk of PD TF. For all the stratified PD-switch groups, death rates were higher than those for PD-first patients.ConclusionsCompared with patients who start renal replacement therapy with PD, those who transfer from HD to PD within the first year on dialysis experience higher rates of PD TF and death, with the highest risk being observed in the initial year after the switch to PD.

scholarly journals A Scientific Symposium “Artificial Organs Today: From in Vitro Assessment to Human Therapies” on the Occasion of the Celebration of the 40th Anniversary of the Macedonian Academy of Sciences and Arts

PRILOZI ◽  
2020 ◽  
Vol 41 (3) ◽  
pp. 91-93
Author(s):  
Momir H. Polenakovic
Keyword(s):  
Treatment Options ◽  
Artificial Organs ◽  
Artificial Organ ◽  
40Th Anniversary ◽  
System Requirements ◽  
In Vitro Assessment ◽  
Academy Of Sciences ◽  
Organ Replacement ◽  
Ageing Populations

AbstractOn the occasion of the celebration of the 40th anniversary of the Macedonian Academy of Sciences and Arts (MASA) the Macedonian Society of Nephrology, Dialysis, Transplantation and Artificial Organs (MSNDTAO) organized a one day symposium titled: “Artificial Organs Today: From in vitro assessment to human therapies”, on September 28, 2007 at the Macedonian Academy of Sciences and Arts. The following sessions were held: Artificial Organs in Front of the Ageing Populations; System Requirements for Artificial Organ Technology; Tools for Artificial Organ Technology; Extracorporeal Blood Circuits in Organ Replacement Therapies; Treatment Options for Blood Purification Therapies. Presentation were delivered by: Horst Klinkmann, Germany; Jörg Vienken, Germany; Jens Hartmann, Austria; Udo Losert, Austria; Jan Wojcicki, Poland; Helmut Mann and Siegfried Stiller, Germany; Beat Walpoth, Switzerland; Juan F. del Cañizo, Spain; Borce Georgievski, Macedonia; Bernd Stegmayr, Sweden; Momir Polenakovic, Macedonia; Petar Kes, Croatia; Aleksandar Sikole, Macedonia; Wolfgang Ramlow, Germany; Dieter Falkenhagen, Austria. These meetings are significant for the application and development of the artificial organs in patients.

Next-generation antibody-guided enzyme replacement therapy for lysosomal storage diseases

2019 ◽  
Author(s):  
Andrew Baik ◽  
Nina Aaron ◽  
Matthew Birnbaum ◽  
Philip Calafati ◽  
Christopher Schoenherr ◽  
...  
Keyword(s):  
Enzyme Replacement Therapy ◽  
Replacement Therapy ◽  
Lysosomal Storage Diseases ◽  
Next Generation ◽  
Lysosomal Storage ◽  
Storage Diseases ◽  
Enzyme Replacement

Next-generation antibody-guided enzyme replacement therapy in Pompe disease mice

2018 ◽  
Vol 123 (2) ◽  
pp. S21 ◽  
Author(s):  
Andrew Baik ◽  
Nina Aaron ◽  
Matthew S. Birnbaum ◽  
Christopher J. Schoenherr ◽  
Andrew J. Murphy ◽  
...  
Keyword(s):  
Enzyme Replacement Therapy ◽  
Replacement Therapy ◽  
Pompe Disease ◽  
Next Generation ◽  
Enzyme Replacement

Organ Replacement Therapy

2013 ◽  
pp. 1389-1389
Author(s):  
Chad D. Jensen ◽  
Amy F. Sato ◽  
Elissa Jelalian ◽  
Elizabeth R. Pulgaron ◽  
Alan M. Delamater ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Organ Replacement
Sign in / Sign up

Export Citation Format

Share Document