scholarly journals A high-performance thioredoxin-based scaffold for peptide immunogen construction: proof-of-concept testing with a human papillomavirus epitope

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Elena Canali ◽  
Angelo Bolchi ◽  
Gloria Spagnoli ◽  
Hanna Seitz ◽  
Ivonne Rubio ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Performance ◽  
Proof Of Concept ◽  
Peptide Immunogen

scholarly journals Denaturing High-Performance Liquid Chromatography for Detecting and Typing Genital Human Papillomavirus

2003 ◽  
Vol 41 (12) ◽  
pp. 5563-5571 ◽  
Author(s):  
J. Li ◽  
D. S. Gerhard ◽  
Z. Zhang ◽  
P. C. Huettner ◽  
J. Wright ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Human Papillomavirus ◽  
High Performance

High Performance BLAST Over the Grid

2011 ◽  
pp. 121-148 ◽  
Author(s):  
Vincent Breton ◽  
Eddy Caron ◽  
Frederic Desprez ◽  
Gael Le Mahec
Keyword(s):  
Data Management ◽  
High Performance ◽  
Large Scale ◽  
Proof Of Concept ◽  
Experimental Platform ◽  
Complex Problems ◽  
Production Platform ◽  
And Storage

As grids become more and more attractive for solving complex problems with high computational and storage requirements, bioinformatics starts to be ported on large scale platforms. The BLAST kernel, one of the main cornerstone of high performance genomics, was one the first application ported on such platform. However, if a simple parallelization was enough for the first proof of concept, its use in production platform needed more optimized algorithms. In this chapter, we review existing parallelization and “gridification” approaches as well as related issues such as data management and replication, and a case study using the DIET middleware over the Grid’5000 experimental platform.

scholarly journals HPTLC-DESI-HRMS-Based Profiling of Anthraquinones in Complex Mixtures—A Proof-of-Concept Study Using Crude Extracts of Chilean Mushrooms

Foods ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 156 ◽  
Author(s):  
Annegret Laub ◽  
Ann-Katrin Sendatzki ◽  
Götz Palfner ◽  
Ludger A. Wessjohann ◽  
Jürgen Schmidt ◽  
...  
Keyword(s):  
High Performance ◽  
High Resolution Mass Spectrometry ◽  
Desorption Electrospray Ionization ◽  
Negative Ion ◽  
Fragmentation Pattern ◽  
Proof Of Concept ◽  
Concept Study ◽  
Crude Extracts ◽  
Marker Compounds ◽  
Characteristic Fragmentation

High-performance thin-layer chromatography (HPTLC) coupled with negative ion desorption electrospray ionization high-resolution mass spectrometry (DESI-HRMS) was used for the analysis of anthraquinones in complex crude extracts of Chilean dermocyboid Cortinarii. For this proof-of-concept study, the known anthraquinones emodin, physcion, endocrocin, dermolutein, hypericin, and skyrin were identified by their elemental composition. HRMS also allowed the differentiation of the investigated anthraquinones from accompanying compounds with the same nominal mass in the crude extracts. An investigation of the characteristic fragmentation pattern of skyrin in comparison with a reference compound showed, exemplarily, the feasibility of the method for the determination of these coloring, bioactive and chemotaxonomically important marker compounds. Accordingly, we demonstrate that the coupling of HPTLC with DESI-HRMS represents an advanced and efficient technique for the detection of anthraquinones in complex matrices. This analytical approach may be applied in the field of anthraquinone-containing food and plants such as Rheum spp. (rhubarb), Aloe spp., Morinda spp., Cassia spp. and others. Furthermore, the described method can be suitable for the analysis of anthraquinone-based colorants and dyes, which are used in the food, cosmetic, and pharmaceutical industry.

Flexible and miniaturized power divider

2015 ◽  
Vol 8 (3) ◽  
pp. 547-557 ◽  
Author(s):  
François Burdin ◽  
Florence Podevin ◽  
Philippe Ferrari
Keyword(s):  
Millimeter Wave ◽  
Transmission Lines ◽  
High Performance ◽  
Size Reduction ◽  
Input Port ◽  
Power Divider ◽  
Proof Of Concept ◽  
Millimeter Wave Range ◽  
Measurement Results ◽  
Wave Range

A new flexible and miniaturized power divider (PD), based on the Wilkinson PD topology, is carried out in this paper. Flexibility and size reduction are achieved simultaneously thanks to both an open-stub loading the input port and additional transmission lines (TLines) connecting the output ports to the isolation resistance. Design equations and rules are given. As a proof-of-concept, two PDs working at 2.45 GHz were fabricated and measured. Then, on the basis of the previous developments, a 1:4 power-dividing feeding network was realized. It highlights the high performance and flexibility of the proposed PD. Agreement between simulation and measurement results is very good, for PDs as well as for the feeding network, thus validating the proposed approach. This concept is straightforward to be applied at higher frequencies, in particular in the millimeter-wave range on CMOS technologies, where flexibility in the choice of the TLines characteristic impedances and size reduction are mandatory.

scholarly journals Tip- and Laser-based 3D Nanofabrication in Extended Macroscopic Working Areas

2021 ◽  
Author(s):  
Ingo Ortlepp ◽  
Thomas Fröhlich ◽  
Roland Füßl ◽  
Johann Reger ◽  
Christoph Schäffel ◽  
...  
Keyword(s):  
High Performance ◽  
Semiconductor Industry ◽  
Life Sciences ◽  
Basic Research ◽  
Paradigm Change ◽  
Proof Of Concept ◽  
Custom Design ◽  
Global Companies ◽  
20 Nm ◽  
Intense Research

AbstractThe field of optical lithography is subject to intense research and has gained enormous improvement. However, the effort necessary for creating structures at the size of 20 nm and below is considerable using conventional technologies. This effort and the resulting financial requirements can only be tackled by few global companies and thus a paradigm change for the semiconductor industry is conceivable: custom design and solutions for specific applications will dominate future development (Fritze in: Panning EM, Liddle JA (eds) Novel patterning technologies. International society for optics and photonics. SPIE, Bellingham, 2021. 10.1117/12.2593229). For this reason, new aspects arise for future lithography, which is why enormous effort has been directed to the development of alternative fabrication technologies. Yet, the technologies emerging from this process, which are promising for coping with the current resolution and accuracy challenges, are only demonstrated as a proof-of-concept on a lab scale of several square micrometers. Such scale is not adequate for the requirements of modern lithography; therefore, there is the need for new and alternative cross-scale solutions to further advance the possibilities of unconventional nanotechnologies. Similar challenges arise because of the technical progress in various other fields, realizing new and unique functionalities based on nanoscale effects, e.g., in nanophotonics, quantum computing, energy harvesting, and life sciences. Experimental platforms for basic research in the field of scale-spanning nanomeasuring and nanofabrication are necessary for these tasks, which are available at the Technische Universität Ilmenau in the form of nanopositioning and nanomeasuring (NPM) machines. With this equipment, the limits of technical structurability are explored for high-performance tip-based and laser-based processes for enabling real 3D nanofabrication with the highest precision in an adequate working range of several thousand cubic millimeters.

Synthesis, Decoding, and Preliminary Screening of a Bead-Supported Split-Pool Library of Triboronic Acid Receptors for Complex Oligosaccharides

2007 ◽  
Vol 60 (11) ◽  
pp. 824 ◽  
Author(s):  
Sukhdev Manku ◽  
Dennis G. Hall
Keyword(s):  
High Performance Liquid Chromatography ◽  
Boronic Acid ◽  
High Performance ◽  
Combinatorial Library ◽  
Tight Binding ◽  
Mass Spectrometric ◽  
Controlled Synthesis ◽  
Proof Of Concept ◽  
Preliminary Screening ◽  
Neutral Water

A controlled synthesis of a prototypic bead-supported combinatorial library of 289 triamine-derived triboronic acid receptors for oligosaccharides was achieved using the split-pool strategy with bead encoding using the method of partial termination synthesis. Although a preliminary screening of the library against the Lewis-b tetrasaccharide in neutral water failed to show tight-binding receptors, single beads from the library can be decoded efficiently using high performance liquid chromatography with electrospray mass spectrometric detection. This proof-of-concept could become generally applicable with the help of improved glycoside-binding boronic acid units.

scholarly journals Testing of high performance asymmetric tubular BSCF membranes under pressurized operation – A proof-of-concept study on a 7 tube module

2021 ◽  
pp. 120176
Author(s):  
Qiang Hu ◽  
Stéven Pirou ◽  
Kurt Engelbrecht ◽  
Ralf Kriegel ◽  
Ute Pippardt ◽  
...  
Keyword(s):  
High Performance ◽  
Proof Of Concept ◽  
Concept Study

scholarly journals Numerical Modelling of a Composite Fuselage Manufactured by Liquid Resin Infusion

2011 ◽  
Vol 62 ◽  
pp. 49-56
Author(s):  
Adrien Perret ◽  
Sébastien Mistou ◽  
Louis Etienne Denaud ◽  
Thierry Mollé ◽  
Claudia Veyrac ◽  
...  
Keyword(s):  
High Performance ◽  
Development Program ◽  
Proof Of Concept ◽  
Finite Elements Analysis ◽  
Resin Infusion ◽  
Liquid Resin ◽  
Aircraft Fuselage ◽  
Industrial Projects ◽  
High Performance Composite ◽  
Liquid Resin Infusion

FUSCOMP (FUSelage COMPosite) is a Research & Development program which has received the label from the Aerospace Valley competitiveness cluster. It will lead to a test of a composite fuselage demonstrator manufactured by the Liquid Resin Infusion (LRI) process. LRI is based on the moulding of high performance composite parts by infusing liquid resin on dry fibers instead of prepreg fabrics. The study of this proof of concept is based on the TBM 850 airframe, a pressurized business turboprop aircraft currently produced by DAHER-SOCATA. Technical achievements will concern numerical methods and finite elements analysis to be used for the modelling of this aircraft composite fuselage structure. Actual industrial projects face composite integrated structure issues as a number of structures (stiffeners,...) are more and more integrated onto the skins of aircraft fuselage. Indeed the main benefit of LRI is to reduce assembly steps which lead to cycle time gain and thus cost reduction. In particular, infusing components and sub-components at the same time avoids riveting parts altogether. However it is necessary to validate the dimensioning of the studied composite structure.

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