scholarly journals Epigenetic silencing of ARRDC3 expression in basal-like breast cancer cells

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Young Hwa Soung ◽  
Kevin Pruitt ◽  
Jun Chung
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Epigenetic Silencing ◽  
Basal Like Breast Cancer

scholarly journals Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Yubao Wang ◽  
Young-Mi Li ◽  
Lukas Baitsch ◽  
Alan Huang ◽  
Yi Xiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mitotic Progression ◽  
Basal Like Breast Cancer

scholarly journals α-Tubulin Acetylation Elevated in Metastatic and Basal-like Breast Cancer Cells Promotes Microtentacle Formation, Adhesion, and Invasive Migration

2014 ◽  
Vol 75 (1) ◽  
pp. 203-215 ◽  
Author(s):  
Amanda E. Boggs ◽  
Michele I. Vitolo ◽  
Rebecca A. Whipple ◽  
Monica S. Charpentier ◽  
Olga G. Goloubeva ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Tubulin Acetylation ◽  
Basal Like Breast Cancer

scholarly journals A homeobox protein, NKX6.1, up-regulates interleukin-6 expression for cell growth in basal-like breast cancer cells

2016 ◽  
Vol 343 (2) ◽  
pp. 177-189 ◽  
Author(s):  
Wenzhao Li ◽  
Junji Itou ◽  
Sunao Tanaka ◽  
Tomomi Nishimura ◽  
Fumiaki Sato ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Interleukin 6 ◽  
Breast Cancer Cells ◽  
Basal Like Breast Cancer ◽  
Homeobox Protein

scholarly journals Selective Effects of Thioridazine on Self-Renewal of Basal-Like Breast Cancer Cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Matthew Tegowski ◽  
Cheng Fan ◽  
Albert S. Baldwin
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cells ◽  
Cell Types ◽  
Breast Cancer Cell Lines ◽  
Breast Cancers ◽  
Self Renewal ◽  
Basal Like Breast Cancer

AbstractSeveral recent publications demonstrated that DRD2-targeting antipsychotics such as thioridazine induce proliferation arrest and apoptosis in diverse cancer cell types including those derived from brain, lung, colon, and breast. While most studies show that 10–20 µM thioridazine leads to reduced proliferation or increased apoptosis, here we show that lower doses of thioridazine (1–2 µM) target the self-renewal of basal-like breast cancer cells, but not breast cancer cells of other subtypes. We also show that all breast cancer cell lines tested express DRD2 mRNA and protein, regardless of thioridazine sensitivity. Further, DRD2 stimulation with quinpirole, a DRD2 agonist, promotes self-renewal, even in cell lines in which thioridazine does not inhibit self-renewal. This suggests that DRD2 is capable of promoting self-renewal in these cell lines, but that it is not active. Further, we show that dopamine can be detected in human and mouse breast tumor samples. This observation suggests that dopamine receptors may be activated in breast cancers, and is the first time to our knowledge that dopamine has been directly detected in human breast tumors, which could inform future investigation into DRD2 as a therapeutic target for breast cancer.

scholarly journals Resveratrol Prevents Epigenetic Silencing of BRCA-1 by the Aromatic Hydrocarbon Receptor in Human Breast Cancer Cells

2010 ◽  
Vol 140 (9) ◽  
pp. 1607-1614 ◽  
Author(s):  
Andreas J. Papoutsis ◽  
Sarah D. Lamore ◽  
Georg T. Wondrak ◽  
Ornella I. Selmin ◽  
Donato F. Romagnolo
Keyword(s):  
Breast Cancer ◽  
Aromatic Hydrocarbon ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Epigenetic Silencing ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Aromatic Hydrocarbon Receptor ◽  
Brca 1
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