scholarly journals Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Ana V. Vega ◽  
Guillermo Avila ◽  
Gary Matthews
Keyword(s):  
Sodium Channels ◽  
Transcriptional Corepressor ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels ◽  
Channel Expression ◽  
Functional Channel

scholarly journals Voltage-Gated Sodium Channels as Potential Biomarkers and Therapeutic Targets for Epithelial Ovarian Cancer

Cancers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 5437
Author(s):  
Iris S. Brummelhuis ◽  
Stephen J. Fiascone ◽  
Kathleen T. Hasselblatt ◽  
Gyorgy Frendl ◽  
Kevin M. Elias
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Sodium Channels ◽  
Additive Effects ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels ◽  
Cells Of Origin ◽  
Channel Expression ◽  
The Relationship ◽  
Potential Biomarkers

Abnormal ion channel expression distinguishes several types of carcinoma. Here, we explore the relationship between voltage-gated sodium channels (VGSC) and epithelial ovarian cancer (EOC). We find that EOC cell lines express most VGSC, but at lower levels than fallopian tube secretory epithelial cells (the cells of origin for most EOC) or control fibroblasts. Among patient tumor samples, lower SCN8A expression was associated with improved overall survival (OS) (median 111 vs. 52 months; HR 2.04 95% CI: 1.21–3.44; p = 0.007), while lower SCN1B expression was associated with poorer OS (median 45 vs. 56 months; HR 0.69 95% CI 0.54–0.87; p = 0.002). VGSC blockade using either anti-epileptic drugs or local anesthetics (LA) decreased the proliferation of cancer cells. LA increased cell line sensitivity to platinum and taxane chemotherapies. While lidocaine had similar additive effects with chemotherapy among EOC cells and fibroblasts, bupivacaine showed a more pronounced impact on EOC than fibroblasts when combined with either carboplatin (ΔAUC −37% vs. −16%, p = 0.003) or paclitaxel (ΔAUC −37% vs. −22%, p = 0.02). Together, these data suggest VGSC are prognostic biomarkers in EOC and may inform new targets for therapy.

scholarly journals Erratum to: Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go?

2020 ◽  
Author(s):  
Zhi-mei Li ◽  
Li-xia Chen ◽  
Hua Li
Keyword(s):  
Open Access ◽  
Sodium Channels ◽  
Voltage Gated ◽  
Internet Portal ◽  
Creative Commons ◽  
Link Type ◽  
Voltage Gated Sodium Channels

The article “Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go?”, written by Zhi-mei LI, Li-xia CHEN, Hua LI, was originally published electronically on the publisher’s internet portal on December 2019 without open access. With the author(s)’ decision to opt for Open Choice, the copyright of the article is changed to © The Author(s) 2020 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The original article has been corrected.Corresponding authors: Li-xia CHEN, Hua LI

scholarly journals μ‐Conotoxin KIIIA peptidomimetics that block human voltage‐gated sodium channels

2020 ◽  
Author(s):  
Astrid Knuhtsen ◽  
Rachel Whiting ◽  
Fergus S. McWhinnie ◽  
Charlotte Whitmore ◽  
Brian O. Smith ◽  
...  
Keyword(s):  
Sodium Channels ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels
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