scholarly journals Identification of Two Maternal Transmission Ratio Distortion Loci in Pedigrees of the Framingham Heart Study

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Yang Liu ◽  
Liangliang Zhang ◽  
Shuhua Xu ◽  
Landian Hu ◽  
Laurence D. Hurst ◽  
...  
Keyword(s):  
Framingham Heart Study ◽  
Transmission Ratio Distortion ◽  
Transmission Ratio ◽  
Maternal Transmission ◽  
Heart Study ◽  
Ratio Distortion

scholarly journals Transmission-ratio distortion in the Framingham Heart Study

2009 ◽  
Vol 3 (S7) ◽  
Author(s):  
Andrew D Paterson ◽  
Daryl Waggott ◽  
Arne Schillert ◽  
Claire Infante-Rivard ◽  
Shelley B Bull ◽  
...  
Keyword(s):  
Framingham Heart Study ◽  
Transmission Ratio Distortion ◽  
Transmission Ratio ◽  
Heart Study ◽  
Ratio Distortion

scholarly journals Transmission ratio distortion in families from the Framingham Heart Study

BMC Genetics ◽  
2003 ◽  
Vol 4 (Suppl 1) ◽  
pp. S48 ◽  
Author(s):  
Andrew D Paterson ◽  
Lei Sun ◽  
Xiao-Qing Liu
Keyword(s):  
Framingham Heart Study ◽  
Transmission Ratio Distortion ◽  
Transmission Ratio ◽  
Heart Study ◽  
Ratio Distortion

scholarly journals A Multi-Megabase Copy Number Gain Causes Maternal Transmission Ratio Distortion on Mouse Chromosome 2

PLoS Genetics ◽  
2015 ◽  
Vol 11 (2) ◽  
pp. e1004850 ◽  
Author(s):  
John P. Didion ◽  
Andrew P. Morgan ◽  
Amelia M.-F. Clayshulte ◽  
Rachel C. Mcmullan ◽  
Liran Yadgary ◽  
...  
Keyword(s):  
Mouse Chromosome ◽  
Copy Number ◽  
Copy Number Gain ◽  
Transmission Ratio Distortion ◽  
Transmission Ratio ◽  
Chromosome 2 ◽  
Maternal Transmission ◽  
Mouse Chromosome 2 ◽  
Ratio Distortion

Maternal Transmission Ratio Distortion of GNAS Loss‐of‐Function Mutations

2020 ◽  
Vol 35 (5) ◽  
pp. 913-919 ◽  
Author(s):  
Sarah Snanoudj ◽  
Arnaud Molin ◽  
Cindy Colson ◽  
Nadia Coudray ◽  
Sylvie Paulien ◽  
...  
Keyword(s):  
Transmission Ratio Distortion ◽  
Transmission Ratio ◽  
Loss Of Function ◽  
Maternal Transmission ◽  
Ratio Distortion

Confirmation of maternal transmission ratio distortion at Om and direct evidence that the maternal and paternal “DDK syndrome” genes are linked

1997 ◽  
Vol 8 (9) ◽  
pp. 642-646 ◽  
Author(s):  
Fernando Pardo-Manuel de Villena ◽  
Anna K. Naumova ◽  
Andrei E. Verner ◽  
Wen-Hui Jin ◽  
Carmen Sapienza
Keyword(s):  
Direct Evidence ◽  
Transmission Ratio Distortion ◽  
Transmission Ratio ◽  
Maternal Transmission ◽  
Ratio Distortion

scholarly journals Maternal Transmission Ratio Distortion at the Mouse Om Locus Results From Meiotic Drive at the Second Meiotic Division

Genetics ◽  
2005 ◽  
Vol 170 (1) ◽  
pp. 327-334 ◽  
Author(s):  
Guangming Wu ◽  
Lanping Hao ◽  
Zhiming Han ◽  
Shaorong Gao ◽  
Keith E. Latham ◽  
...  
Keyword(s):  
Meiotic Division ◽  
Meiotic Drive ◽  
Transmission Ratio Distortion ◽  
Transmission Ratio ◽  
Maternal Transmission ◽  
Ratio Distortion

A Genetic Test to Determine the Origin of Maternal Transmission Ratio Distortion: Meiotic Drive at the Mouse Om Locus

Genetics ◽  
2000 ◽  
Vol 154 (1) ◽  
pp. 333-342 ◽  
Author(s):  
Fernando Pardo-Manuel de Villena ◽  
Elena de la Casa-Esperón ◽  
Tammi L Briscoe ◽  
Carmen Sapienza
Keyword(s):  
Genetic Test ◽  
Polar Body ◽  
Meiotic Drive ◽  
Transmission Ratio Distortion ◽  
Transmission Ratio ◽  
Maternal Transmission ◽  
Chromosome 11 ◽  
Ratio Distortion ◽  
Second Polar Body ◽  
Mouse Chromosome 11

Abstract We have shown previously that the progeny of crosses between heterozygous females and C57BL/6 males show transmission ratio distortion at the Om locus on mouse chromosome 11. This result has been replicated in several independent experiments. Here we show that the distortion maps to a single locus on chromosome 11, closely linked to Om, and that gene conversion is not implicated in the origin of this phenomenon. To further investigate the origin of the transmission ratio distortion we generated a test using the well-known effect of recombination on maternal meiotic drive. The genetic test presented here discriminates between unequal segregation of alleles during meiosis and lethality, based on the analysis of genotype at both the distorted locus and the centromere of the same chromosome. We used this test to determine the cause of the transmission ratio distortion observed at the Om locus. Our results indicate that transmission ratio distortion at Om is due to unequal segregation of alleles to the polar body at the second meiotic division. Because the presence of segregation distortion at Om also depends on the genotype of the sire, our results confirm that the sperm can influence segregation of maternal chromosomes to the second polar body.

Sign in / Sign up

Export Citation Format

Share Document