scholarly journals Characterization of the Relationship of AAV Capsid Domain Swapping to Liver Transduction Efficiency

2007 ◽  
Vol 15 (11) ◽  
pp. 1955-1962 ◽  
Author(s):  
Xuan Shen ◽  
Terry Storm ◽  
Mark A Kay
Author(s):  
D. F. Blake ◽  
L. F. Allard ◽  
D. R. Peacor

Echinodermata is a phylum of marine invertebrates which has been extant since Cambrian time (c.a. 500 m.y. before the present). Modern examples of echinoderms include sea urchins, sea stars, and sea lilies (crinoids). The endoskeletons of echinoderms are composed of plates or ossicles (Fig. 1) which are with few exceptions, porous, single crystals of high-magnesian calcite. Despite their single crystal nature, fracture surfaces do not exhibit the near-perfect {10.4} cleavage characteristic of inorganic calcite. This paradoxical mix of biogenic and inorganic features has prompted much recent work on echinoderm skeletal crystallography. Furthermore, fossil echinoderm hard parts comprise a volumetrically significant portion of some marine limestones sequences. The ultrastructural and microchemical characterization of modern skeletal material should lend insight into: 1). The nature of the biogenic processes involved, for example, the relationship of Mg heterogeneity to morphological and structural features in modern echinoderm material, and 2). The nature of the diagenetic changes undergone by their ancient, fossilized counterparts. In this study, high resolution TEM (HRTEM), high voltage TEM (HVTEM), and STEM microanalysis are used to characterize tha ultrastructural and microchemical composition of skeletal elements of the modern crinoid Neocrinus blakei.


2004 ◽  
Vol 28 (1) ◽  
pp. 15-49
Author(s):  
Simon Perry

Mussorgsky's Sunless cycle is aesthetically and stylistically an anomalous member of his oeuvre. Its notably effaced, pared-down, and withdrawn qualities present challenges to critical interpretation. Its uniqueness, however, renders it a crucial work for furnishing the fullest possible picture of Mussorgsky as a creative artist. The author of its texts, Golenishchev-Kutuzov (whose relationship with Mussorgsky at the time of its writing possibly extended beyond the platonic) has been identified by recent scholarship as an essential "eye-witness" for those to whom Stasov's populist characterization of the composer does not ring entirely true. Golenishchev-Kutuzov believed that in Sunless Mussorgsky first revealed his authentic artistic self. According to Golenishchev-Kutuvoz, Mussorgsky regarded his signal achievement in Sunless to have been the eradication of all elements other than "feeling." In other words, he had thrown off the stylistic shackles imposed by the aesthetics of realism and relied entirely on intuitive harmonic invention as the sole conveyor of a purely subjective, "affective" meaning in the cycle. This hypothesis forms the point of departure for an investigation of select numbers of the cycle. Analysis reveals that the affective aspect is not the only significant element operative. Alongside remnants of the realist style, there is evidence, of varying degrees of subtlety, for a knowing use of symmetrical pitch organization. Mussorgsky not only adapted the usual referential attachments of symmetrically based chromaticism--typically found in Russian operas of the second half of the nineteenth century--he also, through extremely simple but effective means, synthesized the "intuitive" harmonic and "rational" symmetrical elements of the cycle's pitch organization so that the latter emerges seamlessly out of the former. This remarkable synthesis ensures the cycle's uniformity of tone while also allowing for a reading that extends beyond the generally affective to the symbolically more specific. This symbolic level of reading offers several interpretative possibilities, one of which may refer even to the relationship of the poet and the composer. Irrespective of such potentials for interpretation, the most significant achievement in the cycle remains the synthesis of the intuitive/affective and rational/symbolic elements of its organization. Songs 1, 2, 3, and 6 of the cycle are considered in detail.


Entropy ◽  
2019 ◽  
Vol 21 (2) ◽  
pp. 141 ◽  
Author(s):  
Gregg Jaeger

The question of whether virtual quantum particles exist is considered here in light of previous critical analysis and under the assumption that there are particles in the world as described by quantum field theory. The relationship of the classification of particles to quantum-field-theoretic calculations and the diagrammatic aids that are often used in them is clarified. It is pointed out that the distinction between virtual particles and others and, therefore, judgments regarding their reality have been made on basis of these methods rather than on their physical characteristics. As such, it has obscured the question of their existence. It is here argued that the most influential arguments against the existence of virtual particles but not other particles fail because they either are arguments against the existence of particles in general rather than virtual particles per se, or are dependent on the imposition of classical intuitions on quantum systems, or are simply beside the point. Several reasons are then provided for considering virtual particles real, such as their descriptive, explanatory, and predictive value, and a clearer characterization of virtuality—one in terms of intermediate states—that also applies beyond perturbation theory is provided. It is also pointed out that in the role of force mediators, they serve to preclude action-at-a-distance between interacting particles. For these reasons, it is concluded that virtual particles are as real as other quantum particles.


1987 ◽  
Vol 80 (3) ◽  
pp. 287-306 ◽  
Author(s):  
John S. Kloppenborg

The relationship of the preaching and teaching of Jesus to apocalyptic has been a vexed one ever since Albert Schweitzer's assault on the liberal “Lives of Jesus” and his advocacy of consistent eschatology along with his characterization of Jesus’ teachings as interim ethics. While many of the details of Schweitzer's hypothesis failed to be persuasive, his insistence that Jesus’ activity be seen in the context of apocalypticism has made a profound impact on subsequent historical Jesus scholarship and, in spite of his own noncommital stance with regard to the Two Document Hypothesis, on the theological characterization of Q.


1971 ◽  
Vol 123 (4) ◽  
pp. 501-505 ◽  
Author(s):  
J. W. Dale

1. The amino acid composition of the β-lactamase from E. coli (R-1818) was determined. 2. The R-1818 β-lactamase is inhibited by formaldehyde, hydroxylamine, sodium azide, iodoacetamide, iodine and sodium chloride. 3. The Km values for benzylpenicillin, ampicillin and oxacillin have been determined by using the R-factor enzyme from different host species. The same values were obtained, irrespective of the host bacterium. 4. The molecular weight of the enzyme was found to be 44600, and was the same for all host species. 5. The relationship of R-1818 and R-GN238 β-lactamases is discussed.


2002 ◽  
Vol 718 ◽  
Author(s):  
Job Rijssenbeek ◽  
Sylvie Malo ◽  
Takashi Saito ◽  
Vincent Caignaert ◽  
Masaki Azuma ◽  
...  

AbstractPerovskite-like mixed metal ruthenates are of interest owing to their varied electronic and magnetic properties, which are heavily dependent on the ordering of the transition metals. We report the synthesis and structural characterization of the first 1:2 ordered perovskite ruthenate, Sr3CaRu2O9. The structure was determined from a combination of powder X-ray, electron and neutron diffraction data and is characterized by a 1:2 ordering of Ca2+ and Ru5+ over the sixcoordinate B-sites of the perovskite lattice. Sr3CaRu2O9 is the first example of this structure-type to include a majority metal with d electrons (Ru(V), d3). The relationship of this material to the K2NiF4-type Sr1.5Ca0.5RuO4 (i.e., Sr3CaRu2O8) highlights the dramatic effects of the ruthenium valence on the resultant structure. Remarkably, these two structures can be quantitatively interconverted by the appropriate choice of reaction temperature and atmosphere.


CNS Spectrums ◽  
2002 ◽  
Vol 7 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Eliza Coleman ◽  
Raymond R. Goetz ◽  
David Leitman ◽  
Scott Yale ◽  
Ariel Stanford ◽  
...  

ABSTRACTSmell identification deficits are consistently found in schizophrenia (SZ), but little is known about the nature and characterization of this deficit or its relationship to the phenomenology of the illness. This study aims to further delineate smell identification errors in SZ by examining the relationship of patient demographic differences with smell-identification performance. Our results showed that a patient's gender and education were related to odor-identification scores, with better performance seen in female patients and in those with greater educational attainment. However, there was no effect related to age, ethnicity, or socioeconomic status on odor identification. A smell identification deficit was also unrelated to clinical characteristics of the patients, including age at first hospitalization, number of psychiatric hospitalizations, and duration of illness. Odor identification also did not differ by SZ subtype, nor between SZ and schizoaffective disorder patients. These findings emphasize that odor identification deficits in SZ are unrelated to clinical illness features, cannot be explained by other confounds related to olfaction in the general population, and may be core features related to the SZ disease process.


Author(s):  
Julie Thompson Klein

The relationship of interdisciplinarity and literary theory is marked by the boundary work of competing practices deemed inside and outside of the discipline, conflicting claims of specialization and generality, and shifting representations of the concept of interdisciplinarity. The line between text and context has been a recurring point of debate, amplified by tensions between traditional practices and new approaches. The earliest warrants for interdisciplinarity included a synoptic view of knowledge and the social and moral purpose of literary education. Even after institutionalization of the modern system of disciplinarity in the late 19th and early 20th centuries, advocates upheld related claims. Other interests, though, were also apparent, including the practice of borrowing from social sciences, the synchronic paradigm of periodization, interart criticism, and the work of polymaths who posited a broad view of culture. Guides to practice published by the Modern Language Association from the late 1960s through the early 1980s reinforced the power of intrinsic criticism. Yet, as new interests beyond formalist criticism took root, representation of interdisciplinarity changed. The 1992 guide was marked by a heterogeneity of movements that broadened the scope of literary study while shifting theorization of interdisciplinarity in literary studies from earlier warrants to critique and historical, political, and sociological turns in scholarship. Transdisciplinary and transnational redrawings of boundaries are extending the scope of both interdisciplinarity and literary theory. Counter to popular characterization of movements rising and falling, hybrid methodologies combine older and newer approaches, such as combining close readings of texts or deconstructionist analysis with questions of gender or power. Relations of literary studies with other disciplines and interdisciplinary fields also exhibit a growing momentum for intersectionality apparent in the 2007 guide to practice.


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