Dissecting p53 tumor suppressor function in vivo through the analysis of genetically modified mice

2006 ◽  
Vol 13 (6) ◽  
pp. 902-908 ◽  
Author(s):  
T M Johnson ◽  
L D Attardi
Keyword(s):  
Tumor Suppressor ◽  
Genetically Modified ◽  
Tumor Suppressor Function ◽  
P53 Tumor Suppressor ◽  
Suppressor Function ◽  
Genetically Modified Mice

scholarly journals Loss of p53 tumor suppressor function is required for in vivo progression of Friend erythroleukemia

Oncogene ◽  
2001 ◽  
Vol 20 (23) ◽  
pp. 2946-2955 ◽  
Author(s):  
Joanna M Prasher ◽  
Kojo S J Elenitoba-Johnson ◽  
Linda L Kelley
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Function ◽  
P53 Tumor Suppressor ◽  
Suppressor Function

scholarly journals Tumor Suppressor Function of miR-127-3p and miR-376a-3p in Osteosarcoma Cells

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2019 ◽  
Author(s):  
Joerg Fellenberg ◽  
Burkhard Lehner ◽  
Heiner Saehr ◽  
Astrid Schenker ◽  
Pierre Kunz
Keyword(s):  
Tumor Suppressor ◽  
Therapeutic Strategies ◽  
High Dose ◽  
Osteosarcoma Cell ◽  
Tumor Suppressor Function ◽  
Osteosarcoma Cells ◽  
Aberrant Expression ◽  
Suppressor Function

Since the introduction of high-dose chemotherapy about 35 years ago, survival rates of osteosarcoma patients have not been significantly improved. New therapeutic strategies replacing or complementing conventional chemotherapy are therefore urgently required. MicroRNAs represent promising targets for such new therapies, as they are involved in the pathology of multiple types of cancer, and aberrant expression of several miRNAs has already been shown in osteosarcoma. In this study, we identified silencing of miR-127-3p and miR-376a-3p in osteosarcoma cell lines and tissues and investigated their role as potential tumor suppressors in vitro and in vivo. Transfection of osteosarcoma cells (n = 6) with miR-127-3p and miR-376a-3p mimics significantly inhibited proliferation and reduced the colony formation capacity of these cells. In contrast, we could not detect any influence of miRNA restoration on cell cycle and apoptosis induction. The effects of candidate miRNA restoration on tumor engraftment and growth in vivo were analyzed using a chicken chorioallantoic membrane (CAM) assay. Cells transfected with mir-127-3p and miR-376a-3p showed reduced tumor take rates and tumor volumes and a significant decrease of the cumulative tumor volumes to 41% and 54% compared to wildtype cells. The observed tumor suppressor function of both analyzed miRNAs indicates these miRNAs as potentially valuable targets for the development of new therapeutic strategies for the treatment of osteosarcoma.

scholarly journals An African-specific polymorphism in theTP53gene impairs p53 tumor suppressor function in a mouse model

2016 ◽  
Vol 30 (8) ◽  
pp. 918-930 ◽  
Author(s):  
Matthew Jennis ◽  
Che-Pei Kung ◽  
Subhasree Basu ◽  
Anna Budina-Kolomets ◽  
Julia I-Ju Leu ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Mouse Model ◽  
Tumor Suppressor Function ◽  
P53 Tumor Suppressor ◽  
Suppressor Function

scholarly journals CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice

2007 ◽  
Vol 117 (12) ◽  
pp. 3753-3764 ◽  
Author(s):  
Xiuwei Tang ◽  
Yucui Zhu ◽  
Lydia Han ◽  
Arianna L. Kim ◽  
Levy Kopelovich ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Skin Carcinogenesis ◽  
Mutant P53 ◽  
Tumor Suppressor Function ◽  
P53 Tumor Suppressor ◽  
Suppressor Function
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