scholarly journals Increased platelet transfusion requirement is associated with multiple organ dysfunctions in patients undergoing hematopoietic stem cell transplantation

1998 ◽  
Vol 22 (10) ◽  
pp. 999-1003 ◽  
Author(s):  
B Gordon ◽  
S Tarantolo ◽  
E Ruby ◽  
L Stephens ◽  
J Lynch ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Platelet Transfusion ◽  
Transfusion Requirement ◽  
Multiple Organ ◽  
Hematopoietic Stem ◽  
Organ Dysfunctions

scholarly journals New Allogeneic Hematopoietic Stem Cell Transplantation Method: Hematopoietic Stem Cell Transplantation Plus Thymus Transplantation for Intractable Diseases

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Naoki Hosaka
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Malignant Tumors ◽  
Multiple Organ ◽  
Hematopoietic Stem ◽  
Thymus Transplantation

Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) has become a valuable strategy for some intractable diseases, a number of problems remain to be resolved. We have developed a new HSCT method, HSCT + thymus transplantation (TT) from the same donor, which induces elevated T cell function with mild graft-versus-host disease (GVHD) in comparison to conventional HSCT alone and HSCT + donor lymphocyte infusion (HSCT + DLI). This new method is effective in the treatment of several intractable diseases and conditions, such as autoimmune diseases in aging, advanced malignant tumors, exposure to supralethal irradiation, multiple organ transplantation from different donors, and type 2 diabetes mellitus, for which conventional methods are ineffective. Our findings suggest that allo-HSCT + TT is preferable to conventional allo-HSCT alone or allo-HSCT + DLI. This method may become a valuable next-generation HSCT technique.

scholarly journals The treatment of multiple organ dysfunction syndrome caused by gram-negative sepsis in a patient with neutropenia after allogeneic hematopoietic stem cell transplantation: a case report

2020 ◽  
Vol 19 (2) ◽  
pp. 170-176
Author(s):  
A. Yu. Ivanashkin ◽  
V. V. Lazarev ◽  
I. G. Khamin ◽  
I. A. Semenov ◽  
L. N. Shelikhova ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Organ Dysfunction ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Hematopoietic Stem ◽  
Gram Negative

Patients with high-dose chemotherapy-induced immunosuppression are at high risk for infectious complications with multiple organ dysfunction, which may lead to significantly higher mortality. We report a clinical case of multiple organ dysfunction syndrome caused by gram-negative septic shock in a child after allogeneic hematopoietic stem cell transplantation. We describe intensive care treatment modalities employed at different stages of therapy as well as the specifics of vital signs monitoring. The patient's parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.

RBC and platelet transfusion support in the first 30 and 100 days after haploidentical hematopoietic stem cell transplantation

Transfusion ◽  
2019 ◽  
Vol 59 (11) ◽  
pp. 3371-3385 ◽  
Author(s):  
Shan Yuan ◽  
Dongyun Yang ◽  
Ryotaro Nakamura ◽  
Lefan Zhuang ◽  
Monzr M. Al Malki ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Platelet Transfusion ◽  
Hematopoietic Stem
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