Pilot study to train dentists to communicate about oral cancer: the impact on dentists' self-reported behaviour, confidence and beliefs

Bovine leukemia virus (BLV) is a retroviral infection that disrupts the immune function of infected animals. It is widespread among U.S. dairy cattle. In this pilot study, the average total IgA and IgM concentrations in milk, saliva, and serum samples from BLV ELISA-positive (ELISA+) dairy cows were compared against samples from BLV ELISA-negative (ELISA−) cows using the Kruskal–Wallis test (with ties). The results from ELISA+ cows were also stratified by lymphocyte count (LC) and proviral load (PVL). In milk and saliva from ELISA+ cows, the average total IgA and IgM concentrations were decreased compared to ELISA− cows, although this was only statistically significant for saliva IgM in cows with low PVL (p = 0.0424). Numerically, the average total IgA concentrations were 33.6% lower in milk and 23.7% lower in saliva, and the average total IgM concentrations were 42.4% lower in milk and 15.5% lower in saliva. No significant differences were observed in the total serum IgA concentrations, regardless of PVL and LC. The total serum IgM from ELISA+ cows was significantly decreased (p = 0.0223), with the largest decreases occurring in the highest PVL and LC subgroups. This pilot study is a first step in investigating the impact of BLV on mucosal immunity and will require further exploration in each of the various stages of disease progression.

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Time-to-Treatment in Oral Cancer: Causes and Implications for Survival

Cancers ◽

10.3390/cancers13061321 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1321

Author(s):

Constanza Saka-Herrán ◽

Enric Jané-Salas ◽

Antoni Mari-Roig ◽

Albert Estrugo-Devesa ◽

José López-López

Keyword(s):

Oral Cancer ◽

Previous Treatment ◽

Diagnostic Procedures ◽

Original Data ◽

Primary Treatment ◽

Medical Attention ◽

Time Interval ◽

Pre Treatment ◽

The Impact ◽

Lack Of Knowledge

The purpose of this review was to identify and describe the causes that influence the time-intervals in the pathway of diagnosis and treatment of oral cancer and to assess its impact on prognosis and survival. The review was structured according to the recommendations of the Aarhus statement, considering original data from individual studies and systematic reviews that reported outcomes related to the patient, diagnostic and pre-treatment intervals. The patient interval is the major contributor to the total time-interval. Unawareness of signs and/or symptoms, denial and lack of knowledge about oral cancer are the major contributors to the process of seeking medical attention. The diagnostic interval is influenced by tumor factors, delays in referral due to higher number of consultations and previous treatment with different medicines or dental procedures and by professional factors such as experience and lack of knowledge related to the disease and diagnostic procedures. Patients with advanced stage disease, primary treatment with radiotherapy, treatment at an academic facility and transitions in care are associated with prolonged pre-treatment intervals. An emerging body of evidence supports the impact of prolonged pre-treatment and treatment intervals with poorer survival from oral cancer.

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In Reply to the Letter to the Editor Regarding “The Impact of Work-Related Factors on Risk of Resident Burnout: A Global Neurosurgery Pilot Study”

World Neurosurgery ◽

10.1016/j.wneu.2020.11.138 ◽

2021 ◽

Vol 146 ◽

pp. 441

Author(s):

Walter C. Jean ◽

Hasan R. Syed

Keyword(s):

Pilot Study ◽

Related Factors ◽

Work Related ◽

Letter To The Editor ◽

Resident Burnout ◽

The Impact

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High Expression of KLF10 Is Associated with Favorable Survival in Patients with Oral Squamous Cell Carcinoma

Medicina ◽

10.3390/medicina57010017 ◽

2020 ◽

Vol 57 (1) ◽

pp. 17

Author(s):

Chung-Min Yeh ◽

Yi-Ju Lee ◽

Po-Yun Ko ◽

Yueh-Min Lin ◽

Wen-Wei Sung

Keyword(s):

Survival Rate ◽

Oral Cancer ◽

Cancer Patients ◽

Protective Factor ◽

Female Gender ◽

Vital Role ◽

Cancer Stage ◽

Independent Prognostic Marker ◽

Oral Cancer Patients ◽

The Impact

Background and objectives: Krüppel-like transcription factor 10 (KLF10) plays a vital role in regulating cell proliferation, including the anti-proliferative process, activation of apoptosis, and differentiation control. KLF10 may also act as a protective factor against oral cancer. We studied the impact of KLF10 expression on the clinical outcomes of oral cancer patients to identify its role as a prognostic factor in oral cancer. Materials and Methods: KLF10 immunoreactivity was analyzed by immunohistochemical (IHC) stain analysis in 286 cancer specimens from primary oral cancer patients. The prognostic value of KLF10 on overall survival was determined by Kaplan–Meier analysis and the Cox proportional hazard model. Results: High KLF10 expression was significantly associated with male gender and betel quid chewing. The 5-year survival rate was greater for patients with high KLF10 expression than for those with low KLF10 expression (62.5% vs. 51.3%, respectively; p = 0.005), and multivariate analyses showed that high KLF10 expression was the only independent factor correlated with greater overall patient survival. The significant correlation between high KLF10 expression and a higher 5-year survival rate was observed in certain subgroups of clinical parameters, including female gender, non-smokers, cancer stage T1, and cancer stage N0. Conclusions: KLF10 expression, detected by IHC staining, could be an independent prognostic marker for oral cancer patients.

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