scholarly journals Prostaglandin D2(PGD2); prostaglandin D2 receptor (CRTH2; GPR44; CD294); prostaglandin D2 synthase (PTGDS)

2012 ◽  
Vol 5 (14) ◽  
pp. 368-368 ◽  
Keyword(s):  
D2 Receptor ◽  
Prostaglandin D2 ◽  
Prostaglandin D2 Synthase

Lipocalin Prostaglandin D2 Synthase (LPGDS) Levels following Sleeve Gastrectomy and a Very-Low-Calorie Diet (VLCD)—A Pilot Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 299-LB
Author(s):  
RAYMOND G. LAU ◽  
SUNIL KUMAR ◽  
JENNY LEE ◽  
CHRIS HALL ◽  
THOMAS PALAIA ◽  
...  
Keyword(s):  
Sleeve Gastrectomy ◽  
Pilot Study ◽  
Prostaglandin D2 ◽  
Very Low Calorie Diet ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet ◽  
Prostaglandin D2 Synthase

scholarly journals Treatment of COVID-19 pneumonia and acute respiratory distress with ramatroban, a thromboxane A2 and prostaglandin D2 receptor antagonist: A 4-Patient Case Series Report

2021 ◽  
Author(s):  
Martin L. Ogletree ◽  
Kate Chander Chiang ◽  
Rashmi Kulshreshta ◽  
Aditya Agarwal ◽  
Ashutosh Agarwal ◽  
...  
Keyword(s):  
Respiratory Distress ◽  
Organ Failure ◽  
Viral Infections ◽  
Pulmonary Veins ◽  
D2 Receptor ◽  
Case Series ◽  
Acute Onset ◽  
Lipid Mediator ◽  
Prostaglandin D2 ◽  
Th2 Immune Response

Abstract COVID-19 associated pneumonia and acute respiratory distress syndrome are characterized by a lipid mediator storm with massive increases in lung and systemic thromboxane A2 >> prostaglandin D2. Thromboxane A2 is a potent vasoconstrictor of pulmonary veins >> arteries, and thereby promotes an increase in pulmonary capillary pressures, transudation of fluid into the alveolar space, pulmonary edema and ARDS. Thromboxane A2 also increases vascular permeability, contracts bronchial smooth muscle, triggers and amplifies platelet activation, and promotes a prothrombotic state. PGD2 promotes a Th2 immune response that is atypical for viral infections and inhibits antiviral defense by suppressing interferon λ expression. D-dimers, urinary 11-dehydro-TxB2, and IL-13, a Th2 cytokine, have emerged as key biomarkers of severity and organ failure in COVID-19. Ramatroban is an orally bioavailable, potent, dual antagonist of the thromboxane A2 (TPr) and PGD2 (DPr2) receptors. We report use of ramatroban in 4 COVID-19 outpatients, 22 to 87 years of age, with acute onset / worsening of respiratory distress and hypoxemia. All four patients experienced decrease in respiratory distress and increase in SpO2, within hours of the first dose and thereby avoided hospitalization. By the 5th day all 4 patients had complete resolution of respiratory distress and hypoxemia. Ramatroban (Baynas®, Bayer Yakuhin Ltd., Japan) has an established safety profile, having been indicated in Japan for the treatment of allergic rhinitis for over 20 years. As a broncho-relaxant, anti-vasospastic, anti-thrombotic and immunomodulator, ramatroban addresses the fundamental pathophysiologic mechanisms underlying respiratory and critical organ failure in COVID-19, and therefore merits urgent clinical trials that might impact the ongoing pandemic.

scholarly journals Association of a New-Type Prostaglandin D2 Receptor CRTH2 with Circulating T Helper 2 Cells in Patients with Atopic Dermatitis

2002 ◽  
Vol 119 (3) ◽  
pp. 609-616 ◽  
Author(s):  
Masahiro Iwasaki ◽  
Kinya Nagata ◽  
Shoichi Takano ◽  
Kazuo Takahashi ◽  
Norihisa Ishii ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
D2 Receptor ◽  
Prostaglandin D2 ◽  
T Helper ◽  
T Helper 2 ◽  
New Type

scholarly journals Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression

2019 ◽  
Vol 139 (8) ◽  
pp. 1824-1828.e2
Author(s):  
Yoo Ri Kang ◽  
Soon-Sun Bak ◽  
Min Kyu Kim ◽  
Hyun Woo Joo ◽  
Nanda Maya Mali ◽  
...  
Keyword(s):  
D2 Receptor ◽  
Expression Level ◽  
Prostaglandin D2
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