scholarly journals Histone deacetylase 4 (HDAC4); HDAC5; HDAC7

2011 ◽  
Vol 4 (22) ◽  
pp. 628-628
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase 4

scholarly journals Adipocyte Liver Kinase b1 Suppresses Beige Adipocyte Renaissance Through Class IIa Histone Deacetylase 4

Diabetes ◽  
2017 ◽  
Vol 66 (12) ◽  
pp. 2952-2963 ◽  
Author(s):  
Yangmeng Wang ◽  
Esther Paulo ◽  
Dongmei Wu ◽  
Yixuan Wu ◽  
Wendong Huang ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Beige Adipocyte ◽  
Histone Deacetylase 4 ◽  
Liver Kinase B1

scholarly journals Histone deacetylase 4 mediates SMAD family member 4 deacetylation and induces 5-fluorouracil resistance in breast cancer cells

2013 ◽  
Vol 30 (3) ◽  
pp. 1293-1300 ◽  
Author(s):  
SEONG-LAN YU ◽  
DONG CHUL LEE ◽  
JI WOONG SON ◽  
CHANG GYO PARK ◽  
HOI YOUNG LEE ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Family Member ◽  
Histone Deacetylase ◽  
Breast Cancer Cells ◽  
Histone Deacetylase 4

scholarly journals Hydrogen Sulfide Protects Cardiomyocytes against Apoptosis in Ischemia/Reperfusion through MiR-1-Regulated Histone Deacetylase 4 Pathway

2016 ◽  
Vol 41 (1) ◽  
pp. 10-21 ◽  
Author(s):  
Bo Kang ◽  
Wei Li ◽  
Wang Xi ◽  
Yinghong Yi ◽  
Yundan Ciren ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Protective Effect ◽  
Signaling Pathway ◽  
Tumor Cells ◽  
Histone Deacetylase ◽  
Caspase 3 ◽  
Ischemia Reperfusion ◽  
Underlying Mechanism ◽  
Neonatal Rats ◽  
Histone Deacetylase 4

Background/Aims: Hydrogen sulfide (H<Sub>2</Sub>S) is a powerful inhibitor of cardiomyocytes apoptosis following ischemia/reperfusion (IR) injury, but the underlying mechanism remains unclear. Our previous study showed that microRNA-1 (miR-1) was upregulated by 2.21 fold in the IR group compared with that in the H<Sub>2</Sub>S preconditioned group. MiR-206 affected the process of cardiomyocytes hypertrophy by regulating histone deacetylase 4 (HDAC4). HDAC4 is also known to play an anti-apoptotic role in tumor cells, but its role in the myocardium has not been reported. The aim of this study was to test whether H<Sub>2</Sub>S could inhibit apoptosis of cardiomyocytes through HDAC4 regulation by miR-1 in IR. Methods: Cardiomyocytes of neonatal rats were subjected to hypoxia/reoxygenation (HR) injury with or without H<Sub>2</Sub>S pretreatment to simulate IR injury Cardiomyocytes were transfected with miR-1 mimic or HDAC4 siRNA to evaluate whether the miR-1-HDAC4 signaling pathway was involved in the protective effect of H<Sub>2</Sub>S. Results: HR increased cell apoptosis and caspase-3 cleavage, upregulated miR-1, and downregulated HDAC4. H<Sub>2</Sub>S preconditioning attenuated the apoptosis of cardiomyocytes, caspase-3 cleavage and LDH release, and enhanced cell viability In addition, H<Sub>2</Sub>S downregulated miR-1, and preserved HDAC4 expression. HDAC4 protein was down-regulated by miR-1 mimic. Transfection of cardiomyocytes with miR-1 mimic partially reduced the protective effect of H<Sub>2</Sub>S. Meanwhile, transfection of cardiomyocytes with siRNA to HDAC4 partially abrogated the protective effect of H<Sub>2</Sub>S. Conclusions: The miR-1-HDAC4 signaling pathway is involved in the protective effect of H<Sub>2</Sub>S against the apoptosis of cardiomyocytes during the IR injury process.

scholarly journals Caspase-mediated Specific Cleavage of Human Histone Deacetylase 4

2004 ◽  
Vol 279 (33) ◽  
pp. 34537-34546 ◽  
Author(s):  
Fang Liu ◽  
Melissa Dowling ◽  
Xiang-Jiao Yang ◽  
Gary D. Kao
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase 4

scholarly journals The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells

FEBS Letters ◽  
2006 ◽  
Vol 580 (17) ◽  
pp. 4214-4217 ◽  
Author(s):  
Lee Tuddenham ◽  
Guy Wheeler ◽  
Sofia Ntounia-Fousara ◽  
Jasmine Waters ◽  
Mohammad K. Hajihosseini ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase 4 ◽  
Mouse Cells
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