scholarly journals Solute carrier family 16, member 1 (monocarboxylic acid transporter 1) (SLC16A1; MCT1)

2008 ◽  
Vol 1 (44) ◽  
pp. 1069-1069
Keyword(s):  
Monocarboxylic Acid ◽  
Solute Carrier Family ◽  
Solute Carrier ◽  
Acid Transporter ◽  
Monocarboxylic Acid Transporter

scholarly journals Microarray analysis reveals the inhibition of intestinal expression of nutrient transporters in piglets infected with porcine epidemic diarrhea virus

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Junmei Zhang ◽  
Di Zhao ◽  
Dan Yi ◽  
Mengjun Wu ◽  
Hongbo Chen ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Transporter ◽  
Nutrient Transporters ◽  
Solute Carrier Family ◽  
Diarrhea Virus ◽  
Expression Of Genes ◽  
Sodium Dependent ◽  
Solute Carrier ◽  
Porcine Epidemic Diarrhea ◽  
Acid Transporter

AbstractPorcine epidemic diarrhea virus (PEDV) infection can induce intestinal dysfunction, resulting in severe diarrhea and even death, but the mode of action underlying these viral effects remains unclear. This study determined the effects of PEDV infection on intestinal absorption and the expression of genes for nutrient transporters via biochemical tests and microarray analysis. Sixteen 7-day-old healthy piglets fed a milk replacer were randomly allocated to one of two groups. After 5-day adaption, piglets (n = 8/group) were orally administrated with either sterile saline or PEDV (the strain from Yunnan province) at 104.5 TCID50 (50% tissue culture infectious dose) per pig. All pigs were orally infused D-xylose (0.1 g/kg BW) on day 5 post PEDV or saline administration. One hour later, jugular vein blood samples as well as intestinal samples were collected for further analysis. In comparison with the control group, PEDV infection increased diarrhea incidence, blood diamine oxidase activity, and iFABP level, while reducing growth and plasma D-xylose concentration in piglets. Moreover, PEDV infection altered plasma and jejunal amino acid profiles, and decreased the expression of aquaporins and amino acid transporters (L-type amino acid transporter 1, sodium-independent amino acid transporter, B(°,+)-type amino acid transport protein, sodium-dependent neutral amino acid transporter 1, sodium-dependent glutamate/aspartate transporter 3, and peptide transporter (1), lipid transport and metabolism-related genes (lipoprotein lipase, apolipoprotein A1, apolipoprotein A4, apolipoprotein C2, solute carrier family 27 member 2, solute carrier family 27 member 4, fatty acid synthase, and long-chain acyl-CoA synthetase (3), and glucose transport genes (glucose transporter-2 and insulin receptor) in the jejunum. However, PEDV administration increased mRNA levels for phosphoenolpyruvate carboxykinase 1, argininosuccinate synthase 1, sodium/glucose co-transporter-1, and cystic fibrosis transmembrane conductance regulator in the jejunum. Collectively, these comprehensive results indicate that PEDV infection induces intestinal injury and inhibits the expression of genes encoding for nutrient transporters.

Non-Involvement of the Human Monocarboxylic Acid Transporter 1 (MCT1) in the Transport of Phenolic Acid

2006 ◽  
Vol 70 (8) ◽  
pp. 1928-1933 ◽  
Author(s):  
Hirohito WATANABE ◽  
Takuya YASHIRO ◽  
Yuichi TOHJO ◽  
Yutaka KONISHI
Keyword(s):  
Phenolic Acid ◽  
Monocarboxylic Acid ◽  
Acid Transporter ◽  
Monocarboxylic Acid Transporter
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