scholarly journals Correlation between diffusion tensor imaging parameters and clinical assessments in patients with cervical spondylotic myelopathy with and without high signal intensity

Spinal Cord ◽  
2017 ◽  
Vol 55 (12) ◽  
pp. 1079-1083
Author(s):  
Y Liu ◽  
C Kong ◽  
L Cui ◽  
X Yuan ◽  
P Zhao ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Signal Intensity ◽  
Cervical Spondylotic Myelopathy ◽  
Diffusion Tensor ◽  
High Signal Intensity ◽  
High Signal ◽  
Clinical Assessments ◽  
Imaging Parameters

Multi-shot echo-planar diffusion tensor imaging in cervical spondylotic myelopathy

2020 ◽  
Vol 102-B (9) ◽  
pp. 1210-1218
Author(s):  
Hanwen Zhang ◽  
Li Guan ◽  
Yong Hai ◽  
Yuzeng Liu ◽  
Hongtao Ding ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Clinical Outcomes ◽  
Cervical Spondylotic Myelopathy ◽  
Diffusion Tensor ◽  
Neck Disability Index ◽  
Cord Compression ◽  
Functional Improvement ◽  
High Signal ◽  
Japanese Orthopedic Association ◽  
Neck Disability

Aims The aim of this study was to use diffusion tensor imaging (DTI) to investigate changes in diffusion metrics in patients with cervical spondylotic myelopathy (CSM) up to five years after decompressive surgery. We correlated these changes with clinical outcomes as scored by the Modified Japanese Orthopedic Association (mJOA) method, Neck Disability Index (NDI), and Visual Analogue Scale (VAS). Methods We used multi-shot, high-resolution, diffusion tensor imaging (ms-DTI) in patients with cervical spondylotic myelopathy (CSM) to investigate the change in diffusion metrics and clinical outcomes up to five years after anterior cervical interbody discectomy and fusion (ACDF). High signal intensity was identified on T2-weighted imaging, along with DTI metrics such as fractional anisotropy (FA). MJOA, NDI, and VAS scores were also collected and compared at each follow-up point. Spearman correlations identified correspondence between FA and clinical outcome scores. Results Significant differences in mJOA scores and FA values were found between preoperative and postoperative timepoints up to two years after surgery. FA at the level of maximum cord compression (MCL) preoperatively was significantly correlated with the preoperative mJOA score. FA postoperatively was also significantly correlated with the postoperative mJOA score. There was no statistical relationship between NDI and mJOA or VAS. Conclusion ms-DTI can detect microstructural changes in affected cord segments and reflect functional improvement. Both FA values and mJOA scores showed maximum recovery two years after surgery. The DTI metrics are significantly associated with pre- and postoperative mJOA scores. DTI metrics are a more sensitive, timely, and quantifiable surrogate for evaluating patients with CSM and a potential quantifiable biomarker for spinal cord dysfunction. Cite this article: Bone Joint J 2020;102-B(9):1210–1218.

The motor conduction of cervical spondylotic myelopathy with intramedullary high signal intensity on MRI

2005 ◽  
Vol 1278 ◽  
pp. 253-256
Author(s):  
Ryoichi Shibuya ◽  
Kazuo Yonenobu ◽  
Kouji Yamamoto ◽  
Shigeyuki Kuratsu ◽  
Susumu Johyama ◽  
...  
Keyword(s):  
Signal Intensity ◽  
Cervical Spondylotic Myelopathy ◽  
High Signal Intensity ◽  
High Signal

Comparison between quantitative measurements of diffusion tensor imaging and T2 signal intensity in a large series of cervical spondylotic myelopathy patients for assessment of disease severity and prognostication of recovery

2019 ◽  
Vol 31 (4) ◽  
pp. 473-479 ◽  
Author(s):  
Saman Shabani ◽  
Mayank Kaushal ◽  
Matthew Budde ◽  
Brian Schmit ◽  
Marjorie C. Wang ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Diffusion Tensor Imaging ◽  
Disease Severity ◽  
Signal Intensity ◽  
Cervical Spondylotic Myelopathy ◽  
Goodness Of Fit ◽  
Diffusion Tensor ◽  
Mixed Effects ◽  
Quantitative Measurements

OBJECTIVECervical spondylotic myelopathy (CSM) is a common cause of spinal cord dysfunction. Recently, it has been shown that diffusion tensor imaging (DTI) may be a better biomarker than T2-weighted signal intensity (T2SI) on MRI for CSM. However, there is very little literature on a comparison between the quantitative measurements of DTI and T2SI in the CSM patient population to determine disease severity and recovery.METHODSA prospective analysis of 46 patients with both preoperative DTI and T2-weighted MRI was undertaken. Normalized T2SI (NT2SI), regardless of the presence or absence of T2SI at the level of maximum compression (LMC), was determined by calculating the T2SI at the LMC/T2SI at the level of the foramen magnum. Regression analysis was performed to determine the relationship of fractional anisotropy (FA), a quantitative measure derived from DTI, and NT2SI individually as well their combination with baseline preoperative modified Japanese Orthopaedic Association (mJOA) score and ∆mJOA score at the 3-, 6-, 12-, and 24-month follow-ups. Goodness-of-fit analysis was done using residual diagnostics. In addition, mixed-effects regression analysis was used to evaluate the impact of FA and NT2SI individually. A p value < 0.05 was selected to indicate statistical significance.RESULTSRegression analysis showed a significant positive correlation between FA at the LMC and preoperative mJOA score (p = 0.041) but a significant negative correlation between FA at the LMC and the ΔmJOA score at the 12-month follow-up (p = 0.010). All other relationships between FA at the LMC and the baseline preoperative mJOA score or ∆mJOA score at the 3-, 6-, and 24-month follow-ups were not statistically significant. For NT2SI and the combination of FA and NT2SI, no significant relationships with preoperative mJOA score or ∆mJOA at 3, 6, and 24 months were seen on regression analysis. However, there was a significant correlation of combined FA and NT2SI with ∆mJOA score at the 12-month follow-up. Mixed-effects regression revealed that FA measured at the LMC was the only significant predictor of ΔmJOA score (p = 0.03), whereas NT2SI and time were not. Goodness-of-fit analysis did not show any evidence of lack of fit.CONCLUSIONSIn this large prospective study of CSM patients, FA at LMC appears to be a better biomarker for determining long-term outcomes following surgery in CSM patients than NT2SI or the combination values at LMC.

The Effect of Imaging Parameters of Diffusion Tensor Imaging on Fractional Anisotropy

2007 ◽  
Vol 57 (4) ◽  
pp. 315
Author(s):  
Jae Su Jun ◽  
Hyun Jeong Kim ◽  
Po Song Yang ◽  
Choong Gon Choi ◽  
Sang Joon Kim ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Fractional Anisotropy ◽  
Diffusion Tensor ◽  
Imaging Parameters

scholarly journals The joint involvement in adult onset Still's disease is characterised by a peculiar magnetic resonance imaging and a specific transcriptomic profile

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Piero Ruscitti ◽  
Antonio Barile ◽  
Onorina Berardicurti ◽  
Sonia Iafrate ◽  
Paola Di Benedetto ◽  
...  
Keyword(s):  
Signal Intensity ◽  
Clinical Characteristics ◽  
High Signal Intensity ◽  
Adult Onset Still’S Disease ◽  
Joint Involvement ◽  
High Signal ◽  
Bone Erosions ◽  
Transcriptomic Profile ◽  
Synovial Tissues ◽  
Bone Oedema

AbstractAdult onset Still's disease (AOSD) is a rare systemic autoinflammatory disease, characterised by fever, arthritis, and skin rash, and joint involvement is one of its clinical manifestations. The aims of this work were to assess joint involvement, to describe main patterns of involvement, and associated clinical characteristics. In this work, we aimed at assessing the joint involvement in AOSD by using MRI, to describe main patterns and associated clinical characteristics. In addition, we aimed at assessing the global transcriptomic profile of synovial tissues in AOSD to elucidate possible pathogenic pathways involved. We also evaluated the global transcriptomic profile of synovial tissues to elucidate possible pathogenic pathways involved in the disease. Thus, AOSD patients, who underwent to MRI exam on joints, were assessed to describe patterns of joint involvement and associated clinical characteristics. Some synovial tissues were collected for RNA-sequencing purposes. The most common MRI finding was the presence of synovitis on 60.5%, mainly in peripheral affected joints, with low to intermediate signal intensity on T1-weighted images and intermediate to high signal intensity on T2-fat-saturated weighted and STIR images. Bone oedema and MRI-bone erosions were reported on 34.9% and 25.6% MRI exams, respectively. Patients with MRI-bone erosions showed a higher prevalence of splenomegaly, a more frequent chronic disease course, lower levels of erythrocyte sedimentation rate, and ferritin. In AOSD synovial tissues, a hyper-expression of interleukin (IL)-1, IL-6, and TNF pathways was shown together with ferritin genes. In conclusion, in AOSD patients, the most common MRI-finding was the presence of synovitis, characterised by intermediate to high signal intensity on T2-fat-saturated weighted and STIR images. MRI-bone erosions and bone oedema were also observed. In AOSD synovial tissues, IL-1, IL-6, and TNF pathways together with ferritin genes resulted to be hyper-expressed.

scholarly journals Application of diffusion tensor imaging for the diagnosis of segmental level of dysfunction in cervical spondylotic myelopathy

Spinal Cord ◽  
2015 ◽  
Vol 54 (5) ◽  
pp. 390-395 ◽  
Author(s):  
Y Suetomi ◽  
T Kanchiku ◽  
S Nishijima ◽  
Y Imajo ◽  
H Suzuki ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Cervical Spondylotic Myelopathy ◽  
Diffusion Tensor
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