scholarly journals The preparation of rat’s acellular spinal cord scaffold and co-culture with rat’s spinal cord neuron in vitro

Spinal Cord ◽  
2016 ◽  
Vol 55 (4) ◽  
pp. 411-418 ◽  
Author(s):  
D-X Ban ◽  
Y Liu ◽  
T-W Cao ◽  
S-j Gao ◽  
S-Q Feng
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Neuron ◽  
Cord Neuron

An inhibitory spinal cord neuron

JAMA ◽  
1980 ◽  
Vol 244 (22) ◽  
pp. 2555-2555
Author(s):  
E. A. Neale
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Neuron ◽  
Cord Neuron

Spinal cord neuron response to natural stimuli. A microelectrode study

1973 ◽  
Vol 39 (2) ◽  
pp. 293-306 ◽  
Author(s):  
James E. Heavner ◽  
Rudolph H. de Jong
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Neuron ◽  
Natural Stimuli ◽  
Neuron Response ◽  
Cord Neuron

scholarly journals Oxygen Radicals Elicit Paralysis and Collapse of Spinal Cord Neuron Growth Cones upon Exposure to Proinflammatory Cytokines

2014 ◽  
Vol 2014 ◽  
pp. 1-20 ◽  
Author(s):  
Thomas B. Kuhn
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Nadph Oxidase ◽  
Proinflammatory Cytokines ◽  
Growth Cone ◽  
Growth Cones ◽  
Neuronal Morphology ◽  
Dependent Manner ◽  
Spinal Cord Neuron ◽  
Cord Neuron

A persistent inflammatory and oxidative stress is a hallmark of most chronic CNS pathologies (Alzheimer’s (ALS)) as well as the aging CNS orchestrated by the proinflammatory cytokines tumor necrosis factor alpha (TNFα) and interleukin-1 beta (IL-1β). Loss of the integrity and plasticity of neuronal morphology and connectivity comprises an early step in neuronal degeneration and ultimate decline of cognitive function. We examinedin vitrowhether TNFαor IL-1βimpaired morphology and motility of growth cones in spinal cord neuron cultures. TNFαand IL-1βparalyzed growth cone motility and induced growth cone collapse in a dose-dependent manner reflected by complete attenuation of neurite outgrowth. Scavenging reactive oxygen species (ROS) or inhibiting NADPH oxidase activity rescued loss of neuronal motility and morphology. TNFαand IL-1βprovoked rapid, NOX-mediated generation of ROS in advancing growth cones, which preceded paralysis of motility and collapse of morphology. Increases in ROS intermediates were accompanied by an aberrant, nonproductive reorganization of actin filaments. These findings suggest that NADPH oxidase serves as a pivotal source of oxidative stress in neurons and together with disruption of actin filament reorganization contributes to the progressive degeneration of neuronal morphology in the diseased or aging CNS.

Oxygen radical-induced neurotoxicity in spinal cord neuron cultures

1994 ◽  
Vol 37 (1) ◽  
pp. 62-70 ◽  
Author(s):  
M. Michikawa ◽  
K. T. Lim ◽  
J. G. McLarnon ◽  
S. U. Kim
Keyword(s):  
Spinal Cord ◽  
Oxygen Radical ◽  
Spinal Cord Neuron ◽  
Cord Neuron

scholarly journals Spinal cord neuron death in methyl-4-phenyl-1,2,3,6 tetrahydropyridine induced Parkinsonism

2008 ◽  
Vol 81 ◽  
pp. 60-63
Author(s):  
Bhishamjit S. Chera ◽  
K. Schaecher ◽  
S. Ray ◽  
A. Rocchini ◽  
S. Imam ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Neuron ◽  
Neuron Death ◽  
Cord Neuron

Neuronal Precursor Cell Proliferation on Elastic Substrates

2011 ◽  
Author(s):  
Michelle L. Previtera ◽  
Mason Hui ◽  
Malav Desai ◽  
Devendra Verma ◽  
Rene Schloss ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Precursor Cell ◽  
Injured Spinal Cord ◽  
Spinal Cord Neuron ◽  
Neuronal Precursor ◽  
Cord Injury ◽  
Proliferation And Differentiation ◽  
Elastic Substrates ◽  
Cord Neuron ◽  
Neuronal Precursor Cell

Numerous stem cells therapies have been studied for the replacement of damaged neurons due to spinal cord injury. Our laboratory’s goal is to design an implantable platform for spinal cord neuron (SCN) proliferation and differentiation in order to replace damaged neurons in the injured spinal cord. Based on previous literature, we suspect we can promote neuronal precursor cell (NPC) proliferation and differentiation utilizing elastic matrices.

Canine Spinal Cord Neuron and Axon Myelin Sheath Morphometry

2006 ◽  
Vol 35 (5) ◽  
pp. 284-286 ◽  
Author(s):  
A. C. de Francischini Carvalho ◽  
M. R. Pacheco ◽  
S. M. Baraldi Artoni ◽  
O. Mateus
Keyword(s):  
Spinal Cord ◽  
Myelin Sheath ◽  
Spinal Cord Neuron ◽  
Cord Neuron
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