scholarly journals A comparison of high vs standard tidal volumes in ventilator weaning for individuals with sub-acute spinal cord injuries: a site-specific randomized clinical trial

Spinal Cord ◽  
2015 ◽  
Vol 54 (3) ◽  
pp. 234-238 ◽  
Author(s):  
J J Fenton ◽  
M L Warner ◽  
D Lammertse ◽  
S Charlifue ◽  
L Martinez ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Spinal Cord ◽  
Randomized Clinical Trial ◽  
Spinal Cord Injuries ◽  
Ventilator Weaning ◽  
Site Specific ◽  
A Site

scholarly journals Re-inventing yourself after spinal cord injury: a site-specific randomized clinical trial

Spinal Cord ◽  
2018 ◽  
Vol 57 (4) ◽  
pp. 282-292 ◽  
Author(s):  
Jennifer Coker ◽  
Jeffrey Cuthbert ◽  
Jessica M. Ketchum ◽  
Richard Holicky ◽  
Toby Huston ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Randomized Clinical Trial ◽  
Site Specific ◽  
Cord Injury ◽  
A Site

Prevention of Deep Venous Thrombosis in Patients with Acute Spinal Cord Injuries: Use of Rotating Treatment Tables

Neurosurgery ◽  
1987 ◽  
Vol 20 (5) ◽  
pp. 675-677 ◽  
Author(s):  
Daniel M. Becker ◽  
Marco Gonzalez ◽  
Amilcare Gentili ◽  
Frank Eismont ◽  
Barth A. Green
Keyword(s):  
Clinical Trial ◽  
Spinal Cord ◽  
Clinical Trials ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Randomized Clinical Trial ◽  
Spinal Cord Injuries ◽  
Impedance Plethysmography ◽  
Injured Patients ◽  
Spinal Cord Injured

Abstract A randomized clinical trial of 15 patients with acute spinal cord injuries was performed to test the hypothesis that rotating treatment tables prevent deep venous thrombosis in this population. Four of 5 control (nonrotated) patients developed distal and proximal thrombi, assessed by 125I fibrinogen leg scans and impedance plethysmography. In comparison, only 1 of 10 treated (rotated) patients developed both distal and proximal thrombosis (P = 0.007). These results suggest but do not prove that rotating treatment tables prevent the development of proximal deep venous thrombosis in spinal cord-injured patients. Larger clinical trials are needed to confirm this heretofore undocumented benefit of rotating treatment tables.

scholarly journals Intensive Balance Training for Adults With Incomplete Spinal Cord Injuries: Protocol for an Assessor-Blinded Randomized Clinical Trial

2018 ◽  
Vol 99 (4) ◽  
pp. 420-427 ◽  
Author(s):  
Janelle Unger ◽  
Katherine Chan ◽  
Carol Y Scovil ◽  
B Catharine Craven ◽  
Avril Mansfield ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Spinal Cord ◽  
Randomized Clinical Trial ◽  
Spinal Cord Injuries ◽  
Balance Training

scholarly journals Subcutaneous granulocyte colony-stimulating factor administration for subacute traumatic spinal cord injuries, report of neurological and functional outcomes: a double-blind randomized controlled clinical trial

2019 ◽  
Vol 30 (1) ◽  
pp. 19-30 ◽  
Author(s):  
Nazi Derakhshanrad ◽  
Hooshang Saberi ◽  
Mir Saeed Yekaninejad ◽  
Mohammad Taghi Joghataei
Keyword(s):  
Clinical Trial ◽  
Spinal Cord ◽  
Placebo Group ◽  
Spinal Cord Injuries ◽  
Functional Improvement ◽  
Granulocyte Colony Stimulating Factor ◽  
Double Blind ◽  
Cord Injury ◽  
The Mean ◽  
Stimulating Factor

OBJECTIVEGranulocyte-colony stimulating factor (G-CSF) is a major cytokine that has already been clinically verified for chronic traumatic spinal cord injuries (TSCIs). In this study, the authors set out to determine the safety and efficacy of G-CSF administration for neurological and functional improvement in subacute, incomplete TSCI.METHODSThis phase II/III, prospective, double-blind, placebo-controlled, parallel randomized clinical trial was performed in 60 eligible patients (30 treatment, 30 placebo). Patients with incomplete subacute TSCIs with American Spinal Injury Association Impairment Scale (AIS) grades B, C, and D were enrolled. Patients were assessed using the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) scale, Spinal Cord Independence Measure (SCIM-III) and International Association of Neurorestoratology Spinal Cord Injury Functional Rating Scale (IANR-SCIFRS), just before intervention and at 1, 3, and 6 months, after 7 daily subcutaneous administrations of 300 μg/day of G-CSF in the treatment group and placebo in the control group.RESULTSAmong 60 participants, 28 patients (93.3%) in the G-CSF group and 26 patients (86.6%) in the placebo group completed the study protocol. After 6 months of follow-up, the AIS grade remained unchanged in the placebo group, while in the G-CSF group 5 patients (45.5%) improved from AIS grade B to C, 5 (45.5%) improved from AIS grade C to grade D, and 1 patient (16.7%) improved from AIS grade D to E. The mean ± SEM change in ISNCSCI motor score in the G-CSF group was 14.9 ± 2.6 points, which was significantly greater than in the placebo group (1.4 ± 0.34 points, p < 0.001). The mean ± SEM light-touch and pinprick sensory scores improved by 8.8 ± 1.9 and 10.7 ± 2.6 points in the G-CSF group, while those in the placebo group improved by 2.5 ± 0.60 and 1.2 ± 0.40 points, (p = 0.005 and 0.002, respectively). Evaluation of functional improvement according to the IANR-SCIFRS instrument revealed significantly more functional improvement in the G-CSF group (10.3 ± 1.3 points than in the placebo group (3.0 ± 0.81 points; p < 0.001). A significant difference was also observed between the 2 groups as measured by the SCIM-III instrument (29.6 ± 4.1 vs 10.3 ± 2.2, p < 0.001).CONCLUSIONSIncomplete subacute TSCI is associated with significant motor, sensory, and functional improvement after administration of G-CSF.Clinical trial registration no.: IRCT201407177441N3 (www.irct.ir)

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