Dynamic proteome analysis of spinal cord injury after ischemia–reperfusion in rabbits by two-dimensional difference gel electrophoresis

Spinal Cord ◽  
2013 ◽  
Vol 51 (8) ◽  
pp. 610-615 ◽  
Author(s):  
B Zhu ◽  
Y Li ◽  
M Li ◽  
X Yang ◽  
B Qiu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Gel Electrophoresis ◽  
Ischemia Reperfusion ◽  
Proteome Analysis ◽  
Two Dimensional ◽  
Cord Injury ◽  
Difference Gel Electrophoresis

scholarly journals Proteome Analysis of Hepatocellular Carcinoma by Two-dimensional Difference Gel Electrophoresis

2007 ◽  
Vol 6 (10) ◽  
pp. 1798-1808 ◽  
Author(s):  
Wei Sun ◽  
Baocai Xing ◽  
Yi Sun ◽  
Xiaojuan Du ◽  
Min Lu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gel Electrophoresis ◽  
Proteome Analysis ◽  
Two Dimensional ◽  
Difference Gel Electrophoresis

scholarly journals The Latest View on the Mechanism of Ferroptosis and Its Research Progress in Spinal Cord Injury

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Yixin Chen ◽  
Suixin Liu ◽  
Jianjun Li ◽  
Zhe Li ◽  
Jing Quan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Glutathione Peroxidase ◽  
Mevalonate Pathway ◽  
Morphological Changes ◽  
Ischemia Reperfusion ◽  
Research Progress ◽  
Transsulfuration Pathway ◽  
Cord Injury ◽  
Generative Mechanism

Ferroptosis is a recently identified nonapoptotic form of cell death whose major markers are iron dependence and accumulation of lipid reactive oxygen species, accompanied by morphological changes such as shrunken mitochondria and increased membrane density. It appears to contribute to the death of tumors, ischemia-reperfusion, acute renal failure, and nervous system diseases, among others. The generative mechanism of ferroptosis includes iron overloading, lipid peroxidation, and downstream execution, while the regulatory mechanism involves the glutathione/glutathione peroxidase 4 pathway, as well as the mevalonate pathway and the transsulfuration pathway. In-depth research has continuously developed and enriched knowledge on the mechanism by which ferroptosis occurs. In recent years, reports of the noninterchangeable role played by selenium in glutathione peroxidase 4 and its function in suppressing ferroptosis and the discovery of ferroptosis suppressor protein 1, identified as a ferroptosis resistance factor parallel to the glutathione peroxidase 4 pathway, have expanded and deepened our understanding of the mechanism by which ferroptosis works. Ferroptosis has been reported in spinal cord injury animal model experiments, and the inhibition of ferroptosis could promote the recovery of neurological function. Here, we review the latest studies on mechanism by which ferroptosis occurs, focusing on the ferroptosis execution and the contents related to selenium and ferroptosis suppressor protein 1. In addition, we summarize the current research status of ferroptosis in spinal cord injury. The aim of this review is to better understand the mechanisms by which ferroptosis occurs and its role in the pathophysiological process of spinal cord injury, so as to provide a new idea and frame of reference for further exploration.

Proteome analysis of human hepatocellular carcinoma tissues by two-dimensional difference gel electrophoresis and mass spectrometry

PROTEOMICS ◽  
2005 ◽  
Vol 5 (8) ◽  
pp. 2258-2271 ◽  
Author(s):  
Cynthia R. M. Y. Liang ◽  
Chon Kar Leow ◽  
Jason C. H. Neo ◽  
Gek San Tan ◽  
Siaw Ling Lo ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Hepatocellular Carcinoma ◽  
Gel Electrophoresis ◽  
Proteome Analysis ◽  
Human Hepatocellular Carcinoma ◽  
Two Dimensional ◽  
Difference Gel Electrophoresis

scholarly journals Activated Protein C Reduces the Ischemia/Reperfusion-Induced Spinal Cord Injury in Rats by Inhibiting Neutrophil Activation

2000 ◽  
Vol 232 (2) ◽  
pp. 272-280 ◽  
Author(s):  
Koji Hirose ◽  
Kenji Okajima ◽  
Yuji Taoka ◽  
Mitsuhiro Uchiba ◽  
Hirofumi Tagami ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Protein C ◽  
Ischemia Reperfusion ◽  
Activated Protein C ◽  
Neutrophil Activation ◽  
Cord Injury

The selective poly(ADP)ribose-polymerase 1 inhibitor INO1001 reduces spinal cord injury during porcine aortic cross-clamping-induced ischemia/reperfusion injury

2007 ◽  
Vol 33 (5) ◽  
pp. 845-850 ◽  
Author(s):  
Christian Maier ◽  
Angelika Scheuerle ◽  
Balázs Hauser ◽  
Hubert Schelzig ◽  
Csaba Szabó ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cord Injury
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