scholarly journals A longitudinal investigation into anxiety and depression in the first 2 years following a spinal cord injury

Spinal Cord ◽  
1994 ◽  
Vol 32 (10) ◽  
pp. 675-679 ◽  
Author(s):  
A R Craig ◽  
K M Hancock ◽  
H G Dickson
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Anxiety And Depression ◽  
Longitudinal Investigation ◽  
Cord Injury

scholarly journals Anxiety and depression over the first year of spinal cord injury: a longitudinal study

Spinal Cord ◽  
1993 ◽  
Vol 31 (6) ◽  
pp. 349-357 ◽  
Author(s):  
K M Hancock ◽  
A R Craig ◽  
H G Dickson ◽  
E Chang ◽  
J Martin
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Longitudinal Study ◽  
Anxiety And Depression ◽  
First Year ◽  
Cord Injury

scholarly journals *Poster 40: Race, Ethnicity, and Employment Outcomes 1, 5, and 10 Years Following Spinal Cord Injury: A Longitudinal Investigation

2010 ◽  
Vol 91 (10) ◽  
pp. e17
Author(s):  
Juan Carlos Arango-Lasprilla ◽  
Jessica M. Ketchum ◽  
Katherine Francis ◽  
Allen Lewis ◽  
Paola Premuda ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Employment Outcomes ◽  
Longitudinal Investigation ◽  
Cord Injury ◽  
Race Ethnicity

Caregivers of persons with spinal cord injury: A longitudinal investigation

1994 ◽  
Vol 75 (6) ◽  
pp. 725-726
Author(s):  
J. Scott Richards ◽  
R. Shewchuk ◽  
T.R. Elliott ◽  
J. Bullard
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Longitudinal Investigation ◽  
Cord Injury

Spinal cord injury by clip-compression induces anxiety and depression-like behaviours in female rats: The role of the inflammatory response

2019 ◽  
Vol 78 ◽  
pp. 91-104 ◽  
Author(s):  
Caroline Cunha do Espírito Santo ◽  
Fernando da Silva Fiorin ◽  
Jocemar Ilha ◽  
Marta Maria Medeiros Frescura Duarte ◽  
Tiago Duarte ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Inflammatory Response ◽  
Female Rats ◽  
Anxiety And Depression ◽  
Cord Injury

scholarly journals Anxiety and Depression in Patients with Traumatic Spinal Cord Injury: A Nationwide Population-Based Cohort Study

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0169623 ◽  
Author(s):  
Sher-Wei Lim ◽  
Yow-Ling Shiue ◽  
Chung-Han Ho ◽  
Shou-Chun Yu ◽  
Pei-Hsin Kao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cohort Study ◽  
Population Based ◽  
Anxiety And Depression ◽  
Traumatic Spinal Cord Injury ◽  
Cord Injury

Coexisting mechanical hypersensitivity and anxiety in a rat model of spinal cord injury and the effect of pregabalin, morphine, and midazolam treatment

2011 ◽  
Vol 2 (3) ◽  
pp. 139-145 ◽  
Author(s):  
Cathrine Baastrup ◽  
Troels S. Jensen ◽  
Nanna B. Finnerup
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Anxiety And Depression ◽  
Preclinical Model ◽  
Sprague Dawley ◽  
Mechanical Hypersensitivity ◽  
Anxiolytic Drug ◽  
Cord Injury ◽  
Spinal Cord Contusion

AbstractBackground and purposeSpinal cord injury (SCI) has detrimental consequences that include chronic neuropathic pain, which is seen in 40-50% of patients, and symptoms of anxiety and depression, which affect 13-45% of SCI patients. The coexistence of pain, anxiety, and depression is known from other neuropathic pain conditions, but the relationship between these symptoms is not clear and has not been investigated in a preclinical model of SCI so far.The aim of this study was to investigate anxiety-like behavior and at-level mechanical hypersensitivity following experimental spinal cord contusion (SCC) in female Sprague-Dawley rats, and the effects of analgesic and anxiolytic drugs.MethodsMechanical sensitivity and elevated plus maze (EPM) behavior were measured pre- and postinjury in SCC and sham animals. Pregabalin 30 mg/kg, morphine 3 mg/kg, midazolam 0.5 mg/kg, and 0.9% NaCl were evaluated in a randomly allocated, blinded balanced design.ResultsSCC animals developed persistent at-level mechanical hypersensitivity and decreased open arm activity in the EPM, which indicates an anxiety-like state. Pregabalin, a dual-acting analgesic and anxiolytic drug reduced both hypersensitivity and anxiety-like behavior, while the analgesic drug morphine only reduced hypersensitivity. The anxiolytic drug midazolam in the dose used had no effect on either parameter.ConclusionsSCC animals developed long lasting coexisting at-level mechanical hypersensitivity and anxiety-like behavior, but there was no evidence to support a causal relationship between pain and anxiety following SCI.ImplicationsThe findings that at-level mechanical hypersensitivity and anxiety-like behavior develops concomitantly in the spinal cord contusion models and that both symptoms is persistent provide basis for further investigation of the mechanisms and connection behind these two clinically relevant symptoms after injury to the central nervous system.

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