Membrane Proteome: Unveiling the Human α-helical Membrane Proteome

Author(s):  
Beth Moorefield
Keyword(s):  
2021 ◽  
Vol 7 (9) ◽  
pp. eabe7999
Author(s):  
Klaas Yperman ◽  
Jie Wang ◽  
Dominique Eeckhout ◽  
Joanna Winkler ◽  
Lam Dai Vu ◽  
...  

Eukaryotic cells rely on endocytosis to regulate their plasma membrane proteome and lipidome. Most eukaryotic groups, except fungi and animals, have retained the evolutionary ancient TSET complex as an endocytic regulator. Unlike other coatomer complexes, structural insight into TSET is lacking. Here, we reveal the molecular architecture of plant TSET [TPLATE complex (TPC)] using an integrative structural approach. We identify crucial roles for specific TSET subunits in complex assembly and membrane interaction. Our data therefore generate fresh insight into the differences between the hexameric TSET in Dictyostelium and the octameric TPC in plants. Structural elucidation of this ancient adaptor complex represents the missing piece in the coatomer puzzle and vastly advances our functional as well as evolutionary insight into the process of endocytosis.


2013 ◽  
Vol 12 (3) ◽  
pp. 1188-1198 ◽  
Author(s):  
Ute Haußmann ◽  
Dirk A. Wolters ◽  
Benjamin Fränzel ◽  
Lindsay D. Eltis ◽  
Ansgar Poetsch

2008 ◽  
Vol 8 (1) ◽  
pp. 225 ◽  
Author(s):  
Mónica Barriuso-Iglesias ◽  
Daniela Schluesener ◽  
Carlos Barreiro ◽  
Ansgar Poetsch ◽  
Juan F Martín

PROTEOMICS ◽  
2008 ◽  
Vol 8 (10) ◽  
pp. 2062-2076 ◽  
Author(s):  
Annette Dreisbach ◽  
Andreas Otto ◽  
Dörte Becher ◽  
Elke Hammer ◽  
Alexander Teumer ◽  
...  

2007 ◽  
Vol 21 (14) ◽  
pp. 2389-2397 ◽  
Author(s):  
Claudia Cirulli ◽  
Gennaro Marino ◽  
Angela Amoresano

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