scholarly journals Integrated Systems Pharmacology Analysis of Clinical Drug-Induced Peripheral Neuropathy

2014 ◽  
Vol 3 (5) ◽  
pp. 114 ◽  
Author(s):  
J Hur ◽  
AY Guo ◽  
WY Loh ◽  
EL Feldman ◽  
JPF Bai
Keyword(s):  
Peripheral Neuropathy ◽  
Integrated Systems ◽  
Systems Pharmacology ◽  
Drug Induced ◽  
Clinical Drug

Drug-Induced Peripheral Neuropathy: Diagnosis and Management

2021 ◽  
Vol 21 ◽  
Author(s):  
Diala Merheb ◽  
Georgette Dib ◽  
Maroun Bou Zerdan ◽  
Clara El Nakib ◽  
Saada Alame ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Systematic Approach ◽  
Viral Infections ◽  
Cost Effective ◽  
Nerve Fibers ◽  
Drug Induced ◽  
Vitamin Deficiencies ◽  
Effective Diagnosis ◽  
Different Parts ◽  
Pathophysiologic Mechanisms

: Peripheral neuropathy comes in all shapes and forms and is a disorder which is found in the peripheral nervous system. It can have an acute or chronic onset depending on the multitude of pathophysiologic mechanisms involving different parts of nerve fibers. A systematic approach is highly beneficial when it comes to cost-effective diagnosis. More than 30 causes of peripheral neuropathy exist ranging from systemic and auto-immune diseases, vitamin deficiencies, viral infections, diabetes, etc. One of the major causes of peripheral neuropathy is drug induced disease, which can be split into peripheral neuropathy caused by chemotherapy or by other medications. This review deals with the latest causes of drug induced peripheral neuropathy, the population involved, the findings on physical examination and various workups needed and how to manage each case.

scholarly journals Quantifying Drug‐Induced Bone Marrow Toxicity Using a Novel Haematopoiesis Systems Pharmacology Model

2019 ◽  
Vol 8 (11) ◽  
pp. 858-868 ◽  
Author(s):  
Chiara Fornari ◽  
Lenka Oplustil O'Connor ◽  
Carmen Pin ◽  
Aaron Smith ◽  
James W.T. Yates ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Toxicity ◽  
Systems Pharmacology ◽  
Drug Induced ◽  
Systems Pharmacology Model

scholarly journals An in vitro quantitative systems pharmacology approach for deconvolving mechanisms of drug-induced, multilineage cytopenias

2020 ◽  
Vol 16 (7) ◽  
pp. e1007620
Author(s):  
Jennifer L. Wilson ◽  
Dan Lu ◽  
Nick Corr ◽  
Aaron Fullerton ◽  
James Lu
Keyword(s):  
Systems Pharmacology ◽  
Drug Induced ◽  
Quantitative Systems Pharmacology

Prevention and Management of Drug-Induced Peripheral Neuropathy

Drug Safety ◽  
1991 ◽  
Vol 6 (4) ◽  
pp. 302-314 ◽  
Author(s):  
Line Lisbeth Olesen ◽  
Troels Staehelin Jensen
Keyword(s):  
Peripheral Neuropathy ◽  
Drug Induced

scholarly journals Genome-Wide Screen Identifies Drug-Induced Regulation of the Gene Giant Axonal Neuropathy (Gan) in a Mouse Model of Antiretroviral-Induced Painful Peripheral Neuropathy

2009 ◽  
Vol 11 (1) ◽  
pp. 7-16 ◽  
Author(s):  
Susan G. Dorsey ◽  
Carmen C. Leitch ◽  
Cynthia L. Renn ◽  
Sherrie Lessans ◽  
Barbara A. Smith ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Mouse Model ◽  
Side Effect ◽  
Quantitative Polymerase Chain Reaction ◽  
Axonal Neuropathy ◽  
Protein Product ◽  
Hiv Treatment ◽  
Patient Comfort ◽  
Giant Axonal Neuropathy ◽  
Drug Induced

Painful peripheral neuropathy is a debilitating complication of the treatment of HIV with nucleoside reverse transcriptase inhibitors (NRTIs). Patients are living longer with these drugs; however many develop excruciating, unremitting, and often treatment-limiting neuropathy that is resistant to conventional pain management therapies. Improving patient comfort and quality of life is paramount and depends on a clearer understanding of this devastating side effect. The mechanisms underlying the development of NRTI-induced neuropathy, however, remain unclear. Using a mouse model of NRTI-induced neuropathy, the authors conducted an unbiased whole-genome microarray screen to identify molecular targets in the spinal dorsal horn, which is the location where integration of ascending sensory transmission and descending modulatory effects occur. Analysis of the microarray data identified a change in the gene giant axonal neuropathy 1 (Gan1). Mutation of this gene has been linked to the development of giant axonal neuropathy (GAN), a rare autosomal recessive condition characterized by a progressive sensorimotor neuropathy. Gan1 has not been previously linked to nerve pathologies in other populations. In this study, downregulation of the Gan1 gene and the gene protein product, gigaxonin, was validated via quantitative polymerase chain reaction ([qPCR] gene expression) and Western blot analyses (protein level). Our report is the first to suggest that Gan1 might be a novel molecular target in the development of NRTI-induced peripheral neuropathy with implications for new therapeutic approaches to preventing or reducing a significant side effect of HIV treatment.

scholarly journals Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

2008 ◽  
Vol 105 (1) ◽  
pp. 97-105 ◽  
Author(s):  
Jinghai J. Xu ◽  
Peter V. Henstock ◽  
Margaret C. Dunn ◽  
Arthur R. Smith ◽  
Jeffrey R. Chabot ◽  
...  
Keyword(s):  
Liver Injury ◽  
Cellular Imaging ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Clinical Drug
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