scholarly journals Establishment and differentiation of long-term trophoblast organoid cultures from the human placenta.

2018 ◽  
Author(s):  
Lucy GARDNER ◽  
Lucy Gardner ◽  
Margherita Turco ◽  
Graham Burton ◽  
Ashley Moffett
Keyword(s):  
Human Placenta ◽  
Organoid Cultures

Establishment and differentiation of long-term trophoblast organoid cultures from the human placenta

2020 ◽  
Vol 15 (10) ◽  
pp. 3441-3463 ◽  
Author(s):  
Megan A. Sheridan ◽  
Ridma C. Fernando ◽  
Lucy Gardner ◽  
Michael S. Hollinshead ◽  
Graham J. Burton ◽  
...  
Keyword(s):  
Human Placenta ◽  
Organoid Cultures

Effectiveness of Short-Term and Long-Term Zidovudine Prophylaxis on Detection of HIV-1 Subtype E in Human Placenta and Vertical Transmission

2005 ◽  
Vol 40 (5) ◽  
pp. 545-550 ◽  
Author(s):  
Lertlakana Bhoopat ◽  
Surapan Khunamornpong ◽  
Piyaporn Lerdsrimongkol ◽  
Punnee Sirivatanapa ◽  
Soisaang Sethavanich ◽  
...  
Keyword(s):  
Vertical Transmission ◽  
Human Placenta ◽  
Short Term ◽  
Hiv 1

scholarly journals Patient-derived endometrial organoids from MRKH patients: Insight in disease causing pathways

2021 ◽  
Author(s):  
Sara Y. Brucker ◽  
Thomas Hentrich ◽  
Julia M. Schulze-Hentrich ◽  
Martin Pietzsch ◽  
Noel Wajngarten ◽  
...  
Keyword(s):  
Reproductive Tract ◽  
Ovarian Function ◽  
Female Reproductive Tract ◽  
Mrkh Syndrome ◽  
Powerful Research Tool ◽  
Healthy Control ◽  
Organoid Cultures ◽  
Holding Back

The uterus is responsible for the nourishment and mechanical protection of the developing embryo and fetus and is an essential part in mammalian reproduction. The Mayer-Rokitansky-Kuester-Hauser (MRKH) syndrome is characterized by agenesis of the uterus and upper part of the vagina in females with normal ovarian function. Although heavily studied, the cause of the disease is still enigmatic. Current research in the field of MRKH mainly focusses on DNA-sequencing efforts and, so far, failed to decipher the nature and heterogeneity of the disease, thereby holding back scientific and clinical progress. Here, we developed long-term expandable organoid cultures from endometrium found in uterine rudiment horns of MRKH patients. Phenotypically, they share great similarity with healthy control organoids and are surprisingly fully hormone responsive. Transcriptome analyses, however, identified an array of dysregulated genes that point at potentially disease-causing pathways altered during the development of the female reproductive tract. We consider the endometrial organoid cultures to be a powerful research tool that promise to enable an array of studies into the pathogenic origins of MRKH syndrome and possible treatment opportunities to improve patient quality of life.

scholarly journals Human Placenta as a Biomarker of Environmental Toxins Exposure – Long-Term Morphochemical Monitoring

10.5772/32918 ◽  
2012 ◽  
Author(s):  
Monika Zadrona ◽  
Barbara Nowak ◽  
Maria onierek ◽  
Lucyna Zamorska ◽  
Jzef Niweliski
Keyword(s):  
Human Placenta ◽  
Environmental Toxins

scholarly journals Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium

2017 ◽  
Vol 19 (5) ◽  
pp. 568-577 ◽  
Author(s):  
Margherita Y. Turco ◽  
Lucy Gardner ◽  
Jasmine Hughes ◽  
Tereza Cindrova-Davies ◽  
Maria J. Gomez ◽  
...  
Keyword(s):  
Defined Medium ◽  
Human Endometrium ◽  
Chemically Defined Medium ◽  
Organoid Cultures

scholarly journals Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis

2017 ◽  
Vol 8 (4) ◽  
pp. 822-830 ◽  
Author(s):  
Hedwig S. Kruitwagen ◽  
Loes A. Oosterhoff ◽  
Ingrid G.W.H. Vernooij ◽  
Ingrid M. Schrall ◽  
Monique E. van Wolferen ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Disease Modeling ◽  
Organoid Cultures

scholarly journals Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures

Lab on a Chip ◽  
2022 ◽  
Author(s):  
Johannes Dornhof ◽  
Jochen Kieninger ◽  
Harshini Muralidharan ◽  
Jochen Maurer ◽  
Gerald A. Urban ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cell Cultures ◽  
Metabolic Monitoring ◽  
3D Cell Cultures ◽  
Single Cancer ◽  
Organoid Cultures ◽  
On Chip

An organ-on-chip platform equipped with microsensors for long-term microfluidic cultivation and metabolic monitoring (O2, Glu, Lac) of 3D tumour organoid cultures grown from patient-derived single cancer stem cells.

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