scholarly journals Long-term calcium imaging of ASJ sensory neuron controlling cold tolerance in Caenorhabditis elegans

2014 ◽  
Author(s):  
Atsushi Kuhara ◽  
Tomoyo Ujisawa ◽  
Akane Ohta ◽  
Atsushi Kuhara
Keyword(s):  
Caenorhabditis Elegans ◽  
Cold Tolerance ◽  
Sensory Neuron ◽  
Calcium Imaging

scholarly journals Spectrum of variations in dog-1/FANCJ and mdf-1/MAD1 defective Caenorhabditis elegans strains after long-term propagation

BMC Genomics ◽  
2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Maja Tarailo-Graovac ◽  
Tammy Wong ◽  
Zhaozhao Qin ◽  
Stephane Flibotte ◽  
Jon Taylor ◽  
...  
Keyword(s):  
Caenorhabditis Elegans

Fast whole‐body motor neuron calcium imaging of freely moving Caenorhabditis elegans without coverslip pressed

2021 ◽  
Author(s):  
Haiwen Li ◽  
Fan Feng ◽  
Muyue Zhai ◽  
Jia Zhi Zhang ◽  
Jingyuan Jiang ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Motor Neuron ◽  
Calcium Imaging ◽  
Whole Body ◽  
Freely Moving

scholarly journals Transgenerational fitness effects of lifespan extension by dietary restriction in Caenorhabditis elegans

2021 ◽  
Vol 288 (1950) ◽  
Author(s):  
Edward R. Ivimey-Cook ◽  
Kris Sales ◽  
Hanne Carlsson ◽  
Simone Immler ◽  
Tracey Chapman ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Dietary Restriction ◽  
Mortality Risk ◽  
Lifespan Extension ◽  
Dietary Interventions ◽  
Negative Effects ◽  
Trade Offs ◽  
Wide Range ◽  
Broad Variety

Dietary restriction (DR) increases lifespan in a broad variety of organisms and improves health in humans. However, long-term transgenerational consequences of dietary interventions are poorly understood. Here, we investigated the effect of DR by temporary fasting (TF) on mortality risk, age-specific reproduction and fitness across three generations of descendants in Caenorhabditis elegans . We show that while TF robustly reduces mortality risk and improves late-life reproduction of the individuals subject to TF (P 0 ), it has a wide range of both positive and negative effects on their descendants (F 1 –F 3 ). Remarkably, great-grandparental exposure to TF in early life reduces fitness and increases mortality risk of F 3 descendants to such an extent that TF no longer promotes a lifespan extension. These findings reveal that transgenerational trade-offs accompany the instant benefits of DR, underscoring the need to consider fitness of future generations in pursuit of healthy ageing.

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