scholarly journals Effects of growth hormone treatment on growth plate, bone, and mineral metabolism of young rats with uremia induced by adenine

2017 ◽  
Vol 82 (1) ◽  
pp. 148-154 ◽  
Author(s):  
Débora Claramunt ◽  
Helena Gil-Peña ◽  
Rocío Fuente ◽  
Enrique García-López ◽  
Olaya Hernández Frías ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Plate ◽  
Growth Hormone Treatment ◽  
Mineral Metabolism ◽  
Hormone Treatment ◽  
Young Rats

scholarly journals Erratum: Effects of growth hormone treatment on growth plate, bone, and mineral metabolism of young rats with uremia induced by adenine

2017 ◽  
Vol 82 (5) ◽  
pp. 888-888 ◽  
Author(s):  
Débora Claramunt ◽  
Helena Gil-Peña ◽  
Rocío Fuente ◽  
Enrique García-López ◽  
Olaya Hernández Frías ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Plate ◽  
Growth Hormone Treatment ◽  
Mineral Metabolism ◽  
Hormone Treatment ◽  
Young Rats

scholarly journals Innovative Three-Dimensional Microscopic Analysis of Uremic Growth Plate Discloses Alterations in the Process of Chondrocyte Hypertrophy: Effects of Growth Hormone Treatment

2020 ◽  
Vol 21 (12) ◽  
pp. 4519
Author(s):  
Ángela Fernández-Iglesias ◽  
Rocío Fuente ◽  
Helena Gil-Peña ◽  
Laura Alonso-Durán ◽  
María García-Bengoa ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Plate ◽  
Growth Hormone Treatment ◽  
Three Dimensional ◽  
Microscopic Analysis ◽  
Hormone Treatment ◽  
Gh Treatment ◽  
Chondrocyte Hypertrophy ◽  
Chondrocyte Maturation ◽  
And Function

Chronic kidney disease (CKD) alters the morphology and function of the growth plate (GP) of long bones by disturbing chondrocyte maturation. GP chondrocytes were analyzed in growth-retarded young rats with CKD induced by adenine intake (AD), control rats fed ad libitum (C) or pair-fed with the AD group (PF), and CKD rats treated with growth hormone (ADGH). In order to study the alterations in the process of GP maturation, we applied a procedure recently described by our group to obtain high-quality three-dimensional images of whole chondrocytes that can be used to analyze quantitative parameters like cytoplasm density, cell volume, and shape. The final chondrocyte volume was found to be decreased in AD rats, but GH treatment was able to normalize it. The pattern of variation in the cell cytoplasm density suggests that uremia could be causing a delay to the beginning of the chondrocyte hypertrophy process. Growth hormone treatment appears to be able to compensate for this disturbance by triggering an early chondrocyte enlargement that may be mediated by Nkcc1 action, an important membrane cotransporter in the GP chondrocyte enlargement.

Differential gene expression induced by growth hormone treatment in the uremic rat growth plate

2008 ◽  
Vol 18 (4) ◽  
pp. 353-359 ◽  
Author(s):  
Helena Gil ◽  
Juan J. Lozano ◽  
Oscar Álvarez-García ◽  
Pablo Secades-Vázquez ◽  
Julián Rodríguez-Suárez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Hormone ◽  
Growth Plate ◽  
Differential Gene Expression ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Rat Growth ◽  
Differential Gene

Effect of glucocorticoid and growth hormone treatment on proinsulin levels in humans

Diabetes ◽  
1993 ◽  
Vol 42 (7) ◽  
pp. 1082-1085 ◽  
Author(s):  
S. E. Kahn ◽  
F. F. Horber ◽  
R. L. Prigeon ◽  
M. W. Haymond ◽  
D. Porte
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment
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