scholarly journals Thyroid-stimulating hormone levels in newborns and early life exposure to endocrine-disrupting chemicals: analysis of three European mother–child cohorts

2017 ◽  
Vol 82 (3) ◽  
pp. 429-437 ◽  
Author(s):  
Marijke de Cock ◽  
Michiel R de Boer ◽  
Eva Govarts ◽  
Nina Iszatt ◽  
Lubica Palkovicova ◽  
...  
Keyword(s):  
Early Life ◽  
Endocrine Disrupting Chemicals ◽  
Thyroid Stimulating Hormone ◽  
Hormone Levels ◽  
Early Life Exposure ◽  
Endocrine Disrupting ◽  
Stimulating Hormone

scholarly journals Early Life Exposure to Endocrine-Disrupting Chemicals Causes Lifelong Molecular Reprogramming of the Hypothalamus and Premature Reproductive Aging

2011 ◽  
Vol 25 (12) ◽  
pp. 2157-2168 ◽  
Author(s):  
Andrea C. Gore ◽  
Deena M. Walker ◽  
Aparna M. Zama ◽  
AnnMarie E. Armenti ◽  
Mehmet Uzumcu
Keyword(s):  
Early Life ◽  
Endocrine Disrupting Chemicals ◽  
Reproductive Aging ◽  
Early Life Exposure ◽  
Endocrine Disrupting

scholarly journals Endocrine disruption of oestrogen action and female reproductive tract cancers

2013 ◽  
Vol 21 (2) ◽  
pp. T13-T31 ◽  
Author(s):  
Douglas A Gibson ◽  
Philippa T K Saunders
Keyword(s):  
Endometrial Cancer ◽  
Reproductive System ◽  
Early Life ◽  
Reproductive Tract ◽  
Endocrine Disrupting Chemicals ◽  
Reproductive Function ◽  
Female Reproductive Tract ◽  
Early Life Exposure ◽  
Endocrine Disrupting ◽  
Robust Evidence

Endocrine disrupting chemicals (EDC) are ubiquitous and persistent compounds that have the capacity to interfere with normal endocrine homoeostasis. The female reproductive tract is exquisitely sensitive to the action of sex steroids, and oestrogens play a key role in normal reproductive function. Malignancies of the female reproductive tract are the fourth most common cancer in women, with endometrial cancer accounting for most cases. Established risk factors for development of endometrial cancer include high BMI and exposure to oestrogens or synthetic compounds such as tamoxifen. Studies on cell and animal models have provided evidence that many EDC can bind oestrogen receptors and highlighted early life exposure as a window of risk for adverse lifelong effects on the reproductive system. The most robust evidence for a link between early life exposure to EDC and adverse reproductive health has come from studies on women who were exposedin uteroto diethylstilbestrol. Demonstration that EDC can alter expression of members of the HOX gene cluster highlights one pathway that might be vulnerable to their actions. In summary, evidence for a direct link between EDC exposure and cancers of the reproductive system is currently incomplete. It will be challenging to attribute causality to any single EDC when exposure and development of malignancy may be separated by many years and influenced by lifestyle factors such as diet (a source of phytoestrogens) and adiposity. This review considers some of the evidence collected to date.

scholarly journals Early-life exposure to endocrine disrupting chemicals associates with childhood obesity

2018 ◽  
Vol 23 (4) ◽  
pp. 182-195 ◽  
Author(s):  
Chunxue Yang ◽  
Hin Kiu Lee ◽  
Alice Pik Shan Kong ◽  
Lee Ling Lim ◽  
Zongwei Cai ◽  
...  
Keyword(s):  
Childhood Obesity ◽  
Early Life ◽  
Endocrine Disrupting Chemicals ◽  
Early Life Exposure ◽  
Endocrine Disrupting
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