scholarly journals Future perspectives of cell therapy for neonatal hypoxic–ischemic encephalopathy

2017 ◽  
Vol 83 (1-2) ◽  
pp. 356-363 ◽  
Author(s):  
Makoto Nabetani ◽  
Haruo Shintaku ◽  
Takashi Hamazaki
Keyword(s):  
Cell Therapy ◽  
Hypoxic Ischemic Encephalopathy ◽  
Future Perspectives ◽  
Ischemic Encephalopathy

scholarly journals Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy

2014 ◽  
Vol 5 ◽  
Author(s):  
Gabriel S. Gonzales-Portillo ◽  
Stephanny Reyes ◽  
Daniela Aguirre ◽  
Mibel M. Pabon ◽  
Cesar V. Borlongan
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Hypoxic Ischemic Encephalopathy ◽  
Ischemic Encephalopathy

scholarly journals Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies

2021 ◽  
Vol 22 (6) ◽  
pp. 3142
Author(s):  
Inês Serrenho ◽  
Miguel Rosado ◽  
Alexandra Dinis ◽  
Carla M. Cardoso ◽  
Mário Grãos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Cell Therapy ◽  
Umbilical Cord ◽  
Stem Cell Therapy ◽  
Perinatal Period ◽  
Hypoxic Ischemic Encephalopathy ◽  
Preclinical Studies ◽  
Mortality And Morbidity ◽  
Ischemic Encephalopathy

Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality and morbidity in the perinatal period. This condition results from a period of ischemia and hypoxia to the brain of neonates, leading to several disorders that profoundly affect the daily life of patients and their families. Currently, therapeutic hypothermia (TH) is the standard of care in developing countries; however, TH is not always effective, especially in severe cases of HIE. Addressing this concern, several preclinical studies assessed the potential of stem cell therapy (SCT) for HIE. With this systematic review, we gathered information included in 58 preclinical studies from the last decade, focusing on the ones using stem cells isolated from the umbilical cord blood, umbilical cord tissue, placenta, and bone marrow. Outstandingly, about 80% of these studies reported a significant improvement of cognitive and/or sensorimotor function, as well as decreased brain damage. These results show the potential of SCT for HIE and the possibility of this therapy, in combination with TH, becoming the next therapeutic approach for HIE. Nonetheless, few preclinical studies assessed the combination of TH and SCT for HIE, and the existent studies show some contradictory results, revealing the need to further explore this line of research.

Cell Therapy for Neonatal Hypoxic–Ischemic Encephalopathy

2010 ◽  
Vol 19 (3) ◽  
pp. 299-310 ◽  
Author(s):  
Pedro M. Pimentel-Coelho ◽  
Rosalia Mendez-Otero
Keyword(s):  
Cell Therapy ◽  
Hypoxic Ischemic Encephalopathy ◽  
Ischemic Encephalopathy

Mesenchymal Stromal Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy

2017 ◽  
pp. 105-120 ◽  
Author(s):  
Carolina Carmen Urrutia Ruiz ◽  
Paulo Henrique Rosado-de-Castro ◽  
Rosalia Mendez-Otero ◽  
Pedro Moreno Pimentel-Coelho
Keyword(s):  
Cell Therapy ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Hypoxic Ischemic Encephalopathy ◽  
Ischemic Encephalopathy
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