scholarly journals Both antenatal and postnatal inflammation contribute information about the risk of brain damage in extremely preterm newborns

2017 ◽  
Vol 82 (4) ◽  
pp. 691-696 ◽  
Author(s):  
Diana Yanni ◽  
◽  
Steven J Korzeniewski ◽  
Elizabeth N Allred ◽  
Raina N Fichorova ◽  
...  
Keyword(s):  
Brain Damage ◽  
Extremely Preterm ◽  
Preterm Newborns

Gestational Age Dependency of Umbilical Cord Serum IL-6 Levels for Detecting Fetal Inflammation

2020 ◽  
Author(s):  
Sota Iwatani ◽  
Takao Kobayashi ◽  
Sachiko Matsui ◽  
Akihiro Hirata ◽  
Miwa Yamamoto ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Gestational Age ◽  
Area Under The Curve ◽  
Roc Curves ◽  
Significant Negative Correlation ◽  
Cord Serum ◽  
Very Preterm ◽  
Key Points ◽  
Extremely Preterm ◽  
Preterm Newborns

Objective The fetal inflammatory response syndrome (FIRS) is characterized by elevated concentrations of inflammatory cytokines in fetal blood, with preterm delivery and morbidity. Umbilical cord serum interleukin-6 (UC-s-IL-6) is an ideal marker for detecting FIRS. However, the effect of gestational age (GA) on UC-s-IL-6 levels has not been reported. This study aimed to determine the relationship between GA and UC-s-IL-6 levels, and GA-dependent cutoff values of UC-s-IL-6 levels for detecting fetal inflammation. Study Design UC-s-IL-6 concentrations were measured in 194 newborns (44 extremely preterm newborns (EPNs) at 22–27 weeks' GA, 68 very preterm newborns (VPNs) at 28–31 weeks' GA, and 82 preterm newborns (PNs) at 32–34 weeks' GA). Linear regression analyses were used to correlate GA and UC-s-IL-6 levels. Receiver operating characteristic (ROC) curves analyses were performed for detecting the presence of funisitis, as the histopathological counterpart of FIRS. Results A significant negative correlation between GA and UC-s-IL-6 levels was found in newborns with severe funisitis (r s =  − 0.427, p = 0.004) and those with mild funisitis (r s =  − 0.396, p = 0.025). ROC curve analyses revealed the area under the curve for detecting funisitis were 0.856, 0.837, and 0.622 in EPNs, VPNs, and PNs, respectively. The UC-s-IL-6 cutoff value in EPNs (28.1 pg/mL) exceeded those in VPNs and PNs (3.7 and 3.0 pg/mL, respectively). Conclusion UC-s-IL-6 levels were inversely correlated with GA especially in newborns with funisitis. Such GA dependency of UC-s-IL-6 should be considered for detecting fetal inflammation. Key Points

scholarly journals Brain damage in preterm newborns and maternal medication: the ELGAN Study

2012 ◽  
Vol 207 (3) ◽  
pp. 192.e1-192.e9 ◽  
Author(s):  
Crystal P. Tyler ◽  
Nigel Paneth ◽  
Elizabeth N. Allred ◽  
Deborah Hirtz ◽  
Karl Kuban ◽  
...  
Keyword(s):  
Brain Damage ◽  
Maternal Medication ◽  
Preterm Newborns

Anemia in Preterm Infants

1996 ◽  
Vol 17 (10) ◽  
pp. 370-370
Author(s):  
Philip Roth
Keyword(s):  
Preterm Infants ◽  
Plasma Volume ◽  
Hemoglobin Concentration ◽  
Fetal Life ◽  
Combined Effects ◽  
Third Trimester ◽  
The Third ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Preterm Newborns

During fetal life, hemoglobin concentration increases from a level of 9 g/dL at l0 weeks' to 14 to 15 g/dL at 22 to 24 weeks' gestation. By the middle of the third trimester, concentrations close to those observed at birth (16 to 17 g/dL) are reached, and little additional change occurs. As a result, cord hemoglobin concentrations in term and preterm newborns are very similar, with the possible exception of the most extremely preterm infants. Immediately after birth, the hemoglobin concentration begins to rise from the combined effects of placental transfusion and the postnatal readjustment of plasma volume. At approximately 8 to 12 hours of life, the hemoglobin plateaus at levels 1 to 2 g/dL above those observed at birth (about 18 g/dL).

scholarly journals Oscillatory respiratory mechanics on the first day of life improves prediction of respiratory outcomes in extremely preterm newborns

2018 ◽  
Vol 85 (3) ◽  
pp. 312-317 ◽  
Author(s):  
Chiara Veneroni ◽  
Linda Wallström ◽  
Richard Sindelar ◽  
Raffaele L. Dellacaʼ
Keyword(s):  
Respiratory Mechanics ◽  
Extremely Preterm ◽  
Respiratory Outcomes ◽  
Preterm Newborns

scholarly journals Elevated Endogenous Erythropoietin Concentrations Are Associated with Increased Risk of Brain Damage in Extremely Preterm Neonates

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0115083 ◽  
Author(s):  
Steven J. Korzeniewski ◽  
Elizabeth Allred ◽  
J. Wells Logan ◽  
Raina N. Fichorova ◽  
Stephen Engelke ◽  
...  
Keyword(s):  
Brain Damage ◽  
Preterm Neonates ◽  
Endogenous Erythropoietin ◽  
Increased Risk ◽  
Extremely Preterm

Neonatal Outcomes in Extremely Preterm Newborns Admitted to Intensive Care after No Active Antenatal Management: A Population-Based Cohort Study

2018 ◽  
Vol 203 ◽  
pp. 150-155 ◽  
Author(s):  
Caroline Diguisto ◽  
Laurence Foix L'Helias ◽  
Andrei S. Morgan ◽  
Pierre-Yves Ancel ◽  
Gilles Kayem ◽  
...  
Keyword(s):  
Cohort Study ◽  
Intensive Care ◽  
Population Based ◽  
Neonatal Outcomes ◽  
Extremely Preterm ◽  
Antenatal Management ◽  
Preterm Newborns

scholarly journals Circulating biomarkers in extremely preterm infants associated with ultrasound indicators of brain damage

2018 ◽  
Vol 22 (3) ◽  
pp. 440-450 ◽  
Author(s):  
Alan Leviton ◽  
Elizabeth N. Allred ◽  
Raina N. Fichorova ◽  
T. Michael O'Shea ◽  
Lynn A. Fordham ◽  
...  
Keyword(s):  
Brain Damage ◽  
Preterm Infants ◽  
Circulating Biomarkers ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

scholarly journals Socioeconomic status and early blood concentrations of inflammation-related and neurotrophic proteins among extremely preterm newborns

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0214154 ◽  
Author(s):  
Alan Leviton ◽  
Elizabeth N. Allred ◽  
Olaf Dammann ◽  
Robert M. Joseph ◽  
Raina N. Fichorova ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Blood Concentrations ◽  
Extremely Preterm ◽  
Preterm Newborns
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