scholarly journals The pattern recognition molecule collectin-L1 in critically ill children

2016 ◽  
Vol 80 (2) ◽  
pp. 237-243 ◽  
Author(s):  
Catherine Ingels ◽  
Ilse Vanhorebeek ◽  
Inge Derese ◽  
Lisbeth Jensen ◽  
Pieter J. Wouters ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Critically Ill ◽  
Critically Ill Children ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

scholarly journals THU0019 INTRON REGIONS OF PIK3AP1 (BCAP) AND SPON2 (SPONDIN-2) GENES ARE DIFFERENTIALLY METHYLATED IN PATIENTS WITH PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS AND ADENITIS (PFAPA) SYNDROME

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 223.3-223
Author(s):  
E. Lovšin ◽  
J. Kovac ◽  
T. Tesovnik ◽  
N. Toplak ◽  
D. Perko ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Pattern Recognition ◽  
Periodic Fever ◽  
Aphthous Stomatitis ◽  
Extracellular Matrix Protein ◽  
Inflammasome Activation ◽  
Cervical Adenitis ◽  
Pfapa Syndrome ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

Background:Periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome is the most common autoinflammatory disease in children, often grouped together with hereditary periodic fever syndromes, although its cause and hereditary nature remain unexplained.Objectives:We investigated whether a differential DNA methylation was present in DNA from peripheral blood mononuclear cells (PBMC) in patients with PFAPA versus a group of healthy young individuals.Methods:A whole epigenome analysis (MeDIP and MBD) was performed using pooled DNA libraries enriched for methylated genomic regions. Of identified candidate genes, two with most significantly different methylation leves were further evaluated with methylation specific restriction enzymes coupled with qPCR (MSRE-qPCR).Results:The analysis showed thatPIK3AP1andSPON2intronic gene regions are differentially methylated in patients with PFAPA. MSRE-qPCR proved as a quick, reliable and cost-effective method to confirm results from MeDIP and MBD.Conclusion:Our findings indicate that B cell adapter protein (BCAP) as PI3K binding inhibitor of inflammation and spondin-2 (SPON2) as a pattern recognition molecule and integrin ligand could play a role in etiology of PFAPA. Their role and impact of changed DNA methylation in PFAPA etiology and autoinflammation need further investigation.References:[1]Wekell P. Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome – PFAPA syndrome. Press Medicale [Internet]. 2019;48(1):e77–87. Available from:https://doi.org/10.1016/j.lpm.2018.08.016[2]K. Theodoropoulou, F. Vanoni, and M. Hofer, “Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome: a Review of the Pathogenesis,”Curr. Rheumatol. Rep., vol. 18:18, 2016.[3]Carpentier SJ, Ni M, Duggan JM, James RG, Cookson BT, Hamerman JA. The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome activation in macrophages through interactions with Flightless-1. Sci Signal. 2019;12(581).[4]He YW, Li H, Zhang J, Hsu CL, Lin E, Zhang N, et al. The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat Immunol. 2004;5(1):88–97.Disclosure of Interests:None declared

scholarly journals Studies of the Pattern Recognition Molecule H-ficolin

2012 ◽  
Vol 287 (11) ◽  
pp. 8071-8081 ◽  
Author(s):  
Rikke M. Zacho ◽  
Lisbeth Jensen ◽  
Randi Terp ◽  
Jens C. Jensenius ◽  
Steffen Thiel
Keyword(s):  
Pattern Recognition ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

scholarly journals Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule

2009 ◽  
Vol 28 (3) ◽  
pp. 286-297 ◽  
Author(s):  
Yili Li ◽  
Chunzhang Cao ◽  
Wei Jia ◽  
Lily Yu ◽  
Min Mo ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Integrin Ligand ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

scholarly journals C1q/TNF-Related Protein 6 Is a Pattern Recognition Molecule That Recruits Collectin-11 from the Complement System to Ligands

2020 ◽  
Vol 204 (6) ◽  
pp. 1598-1606
Author(s):  
Nikolaj Kirketerp-Møller ◽  
Rafael Bayarri-Olmos ◽  
Karen Angeliki Krogfelt ◽  
Peter Garred
Keyword(s):  
Pattern Recognition ◽  
Complement System ◽  
Related Protein ◽  
The Complement System ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

scholarly journals PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition

2016 ◽  
Vol 38 ◽  
pp. 39-44 ◽  
Author(s):  
Cecilia Garlanda ◽  
Sebastien Jaillon ◽  
Andrea Doni ◽  
Barbara Bottazzi ◽  
Alberto Mantovani
Keyword(s):  
Pattern Recognition ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

scholarly journals The Therapeutic Potential of the Humoral Pattern Recognition Molecule PTX3 in Chronic Lung Infection Caused by Pseudomonas aeruginosa

2011 ◽  
Vol 186 (9) ◽  
pp. 5425-5434 ◽  
Author(s):  
Federica Moalli ◽  
Moira Paroni ◽  
Tania Véliz Rodriguez ◽  
Federica Riva ◽  
Nadia Polentarutti ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Pseudomonas Aeruginosa ◽  
Therapeutic Potential ◽  
Lung Infection ◽  
Chronic Lung Infection ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

Properdin: Emerging Roles of a Pattern-Recognition Molecule

2010 ◽  
Vol 28 (1) ◽  
pp. 131-155 ◽  
Author(s):  
Claudia Kemper ◽  
John P. Atkinson ◽  
Dennis E. Hourcade
Keyword(s):  
Pattern Recognition ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

scholarly journals L-ficolin Is a Pattern Recognition Molecule Specific for Acetyl Groups

2004 ◽  
Vol 279 (46) ◽  
pp. 47513-47519 ◽  
Author(s):  
Anders Krarup ◽  
Steffen Thiel ◽  
Annette Hansen ◽  
Teizo Fujita ◽  
Jens C. Jensenius
Keyword(s):  
Pattern Recognition ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule

scholarly journals The Humoral Pattern Recognition Molecule PTX3 Is a Key Component of Innate Immunity against Urinary Tract Infection

Immunity ◽  
2014 ◽  
Vol 40 (4) ◽  
pp. 621-632 ◽  
Author(s):  
Sébastien Jaillon ◽  
Federica Moalli ◽  
Bryndis Ragnarsdottir ◽  
Eduardo Bonavita ◽  
Manoj Puthia ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Innate Immunity ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Pattern Recognition Molecule ◽  
Recognition Molecule
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