scholarly journals In preterm infants, ascending intrauterine infection is associated with lower cerebral tissue oxygen saturation and higher oxygen extraction

2015 ◽  
Vol 77 (5) ◽  
pp. 688-695
Author(s):  
Annemiek M. Roescher ◽  
Albertus Timmer ◽  
Michelle E. van der Laan ◽  
Jan Jaap H. M. Erwich ◽  
Arend F. Bos ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Preterm Infants ◽  
Intrauterine Infection ◽  
Oxygen Extraction ◽  
Tissue Oxygen Saturation ◽  
Tissue Oxygen ◽  
Cerebral Tissue ◽  
Cerebral Tissue Oxygen Saturation

Cerebral tissue oxygen saturation is associated with N-terminal probrain natriuretic peptide in preterm infants on their first day of life

2014 ◽  
Vol 104 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Corinna Binder-Heschl ◽  
Berndt Urlesberger ◽  
Martin Koestenberger ◽  
Bernhard Schwaberger ◽  
Georg M. Schmölzer ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Natriuretic Peptide ◽  
Preterm Infants ◽  
Tissue Oxygen Saturation ◽  
Tissue Oxygen ◽  
Cerebral Tissue ◽  
Cerebral Tissue Oxygen Saturation

Abstract 276: The Effects of Peep and Blood Pressure on Cerebral Tissue Oxygen Saturation During Hemorrhage in Swine

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_4) ◽  
Author(s):  
Jeff R Gould ◽  
Joshua W Lampe ◽  
Lyra Clark ◽  
George Beck ◽  
Brian C Harvey ◽  
...  
Keyword(s):  
Regression Model ◽  
Oxygen Saturation ◽  
Cerebral Oxygenation ◽  
Cerebral Oxygen Saturation ◽  
Right Atrial ◽  
Tissue Oxygen Saturation ◽  
Cerebral Oxygen ◽  
Tissue Oxygen ◽  
Cerebral Tissue ◽  
Cerebral Tissue Oxygen Saturation

Introduction: Positive end-expiratory pressure (PEEP) is used to increase oxygen delivery by preventing end-expiratory alveolar collapse. However, the associated increased intrathoracic pressure can lead to an increase in right atrial pressure, and a decrease in venous return and cardiac output. Near infrared spectroscopy (NIRS) can be used as a non-invasive tool to continuously monitor cerebral tissue oxygen saturation. In this pilot study, we examined the effects of PEEP on cerebral oxygen saturation during a controlled hemorrhage. Methods: Four female, domestic swine (~30 kg), were bled to 3 target levels of mean arterial pressure (MAP; 55, 45, and 35 mm Hg). At each MAP target, 3 levels of PEEP were applied using a mechanical ventilator (5, 10, and 15 cm H 2 O) for ~10 minutes each. Following the reinfusion of shed blood and a recovery period, these interventions were repeated. Measurements included invasive aortic pressure and cerebral oxygen saturation using a commercially available tissue oximeter. A total of 61 epochs were entered into the following regression model: cerebral oxygen saturation = MAP + PEEP + animal number. Each epoch contained data from the last ~2 minutes of each MAP target and PEEP level. Results: The regression model yielded a coefficient of 0.30 for MAP ( P < 0.001) and -0.08 for PEEP ( P = 0.09) and overall, explained 94% of the variance in cerebral oxygenation (adjusted R 2 = 0.94, P < 0.001). While MAP was a stronger predictor in the model, higher PEEP levels appear to result in lower levels of cerebral oxygenation (see figure). Conclusions: Cerebral tissue oxygen saturation declines with lower mean arterial pressures and increased levels of PEEP. NIRS to measure cerebral oxygen saturation may be a useful clinical tool to ensure adequate cerebral oxygenation in patients with hypotension related to hemorrhage, particularly in those patients that require greater than physiologic PEEP to maintain central oxygenation.

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