scholarly journals Lack of EC-SOD worsens alveolar and vascular development in a neonatal mouse model of bleomycin-induced bronchopulmonary dysplasia and pulmonary hypertension

2015 ◽  
Vol 78 (6) ◽  
pp. 634-640 ◽  
Author(s):  
Cassidy Delaney ◽  
Rachel H. Wright ◽  
Jen-Ruey Tang ◽  
Crystal Woods ◽  
Leah Villegas ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Mouse Model ◽  
Bronchopulmonary Dysplasia ◽  
Vascular Development ◽  
Neonatal Mouse

scholarly journals Hypoxic Stress Exacerbates Hyperoxia-Induced Lung Injury in a Neonatal Mouse Model of Bronchopulmonary Dysplasia

Neonatology ◽  
2009 ◽  
Vol 95 (4) ◽  
pp. 299-305 ◽  
Author(s):  
Veniamin Ratner ◽  
Siarhei Slinko ◽  
Irina Utkina-Sosunova ◽  
Anatoly Starkov ◽  
Richard A. Polin ◽  
...  
Keyword(s):  
Lung Injury ◽  
Mouse Model ◽  
Bronchopulmonary Dysplasia ◽  
Neonatal Mouse ◽  
Hypoxic Stress

Calcium‐Sensing Receptor (CaSR) Modulates Hyperoxia‐Induced Airway Hyperreactivity In a Neonatal Mouse Model of Bronchopulmonary Dysplasia

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Ramadan B. Sopi ◽  
Catherine A. Mayer ◽  
Richard J. Martin ◽  
Christina B. Pabelick ◽  
Y. S. Prakash ◽  
...  
Keyword(s):  
Mouse Model ◽  
Bronchopulmonary Dysplasia ◽  
Neonatal Mouse ◽  
Airway Hyperreactivity ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing

scholarly journals Delineating the molecular and histological events that govern right ventricular recovery using a novel mouse model of pulmonary artery de-banding

2019 ◽  
Vol 116 (10) ◽  
pp. 1700-1709 ◽  
Author(s):  
Mario Boehm ◽  
Xuefei Tian ◽  
Yuqiang Mao ◽  
Kenzo Ichimura ◽  
Melanie J Dufva ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Mouse Model ◽  
Pulmonary Artery ◽  
Right Ventricular ◽  
Exercise Capacity ◽  
Pressure Overload ◽  
Left Ventricular ◽  
Sequence Of Events ◽  
Reverse Remodelling ◽  
Rv Function

Abstract Aims The temporal sequence of events underlying functional right ventricular (RV) recovery after improvement of pulmonary hypertension-associated pressure overload is unknown. We sought to establish a novel mouse model of gradual RV recovery from pressure overload and use it to delineate RV reverse-remodelling events. Methods and results Surgical pulmonary artery banding (PAB) around a 26-G needle induced RV dysfunction with increased RV pressures, reduced exercise capacity and caused liver congestion, hypertrophic, fibrotic, and vascular myocardial remodelling within 5 weeks of chronic RV pressure overload in mice. Gradual reduction of the afterload burden through PA band absorption (de-PAB)—after RV dysfunction and structural remodelling were established—initiated recovery of RV function (cardiac output and exercise capacity) along with rapid normalization in RV hypertrophy (RV/left ventricular + S and cardiomyocyte area) and RV pressures (right ventricular systolic pressure). RV fibrotic (collagen, elastic fibres, and vimentin+ fibroblasts) and vascular (capillary density) remodelling were equally reversible; however, reversal occurred at a later timepoint after de-PAB, when RV function was already completely restored. Microarray gene expression (ClariomS, Thermo Fisher Scientific, Waltham, MA, USA) along with gene ontology analyses in RV tissues revealed growth factors, immune modulators, and apoptosis mediators as major cellular components underlying functional RV recovery. Conclusion We established a novel gradual de-PAB mouse model and used it to demonstrate that established pulmonary hypertension-associated RV dysfunction is fully reversible. Mechanistically, we link functional RV improvement to hypertrophic normalization that precedes fibrotic and vascular reverse-remodelling events.

Neonatal Mouse Model: Review of Methods and Results

2001 ◽  
Vol 29 (5) ◽  
pp. 128-137 ◽  
Author(s):  
R. Michael McClain ◽  
Douglas Keller ◽  
Dan Casciano ◽  
Peter Fu ◽  
James MacDonald ◽  
...  
Keyword(s):  
Mouse Model ◽  
Neonatal Mouse ◽  
Model Review

scholarly journals Protective effect of enterovirus-71 (EV71) virus-like particle vaccine against lethal EV71 infection in a neonatal mouse model

2015 ◽  
Vol 12 (2) ◽  
pp. 2473-2480 ◽  
Author(s):  
LEI CAO ◽  
FENGFENG MAO ◽  
ZHENG PANG ◽  
YAO YI ◽  
FENG QIU ◽  
...  
Keyword(s):  
Mouse Model ◽  
Protective Effect ◽  
Enterovirus 71 ◽  
Neonatal Mouse ◽  
Ev71 Infection ◽  
Virus Like Particle

Persistent Pulmonary Hypertension of the Newborn

1991 ◽  
Vol 7 (S1) ◽  
pp. 66-69
Author(s):  
George Lister
Keyword(s):  
Pulmonary Hypertension ◽  
Diaphragmatic Hernia ◽  
Vascular Development ◽  
Clinical Syndrome ◽  
Persistent Pulmonary Hypertension ◽  
Maternal Infection ◽  
Fetal Circulation ◽  
Cns Disease ◽  
Persistent Fetal Circulation

Persistent pulmonary hypertension of the newborn or persistent fetal circulation is a clinical syndrome that is usually apparent within the first 2 days after birth because of the presence of hypoxemia (2;12;19). The syndrome was first described in an abstract by Gersony, Due, and Sinclair (6) in 1969. Two infants were reported who had “RV decompensation, cyanosis and clear lung fields… in the absence of recognizable cardiac, pulmonary, hematologic or CNS disease.” The syndrome has been associated with aspiration of meconium, diaphragmatic hernia, asphyxia, hemorrhage, shock, and maternal infection (4;18). In other cases, there is no clear antecedent event. Despite considerable interest in the problem and a wealth of research related to pulmonary vasoregulation and vascular development in the fetus and newborn, the etiology of the syndrome remains obscure 20 years since its recognition.

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