scholarly journals Cytidine 5′-diphosphocholine ameliorates hyperoxic lung injury in a neonatal rat model

2013 ◽  
Vol 74 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Merih Cetinkaya ◽  
Mehmet Cansev ◽  
Ilker M. Kafa ◽  
Cuneyt Tayman ◽  
Ferhat Cekmez ◽  
...  
Keyword(s):  
Lung Injury ◽  
Rat Model ◽  
Neonatal Rat ◽  
Hyperoxic Lung Injury ◽  
Neonatal Rat Model

scholarly journals Protective Effects of Valproic Acid, a Histone Deacetylase Inhibitor, against Hyperoxic Lung Injury in a Neonatal Rat Model

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0126028 ◽  
Author(s):  
Merih Cetinkaya ◽  
Mehmet Cansev ◽  
Ferhat Cekmez ◽  
Cuneyt Tayman ◽  
Fuat Emre Canpolat ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Lung Injury ◽  
Histone Deacetylase ◽  
Rat Model ◽  
Histone Deacetylase Inhibitor ◽  
Neonatal Rat ◽  
Protective Effects ◽  
Deacetylase Inhibitor ◽  
Hyperoxic Lung Injury ◽  
Neonatal Rat Model

scholarly journals Inhaled vitamin A is more effective than intramuscular dosing in mitigating hyperoxia-induced lung injury in a neonatal rat model of bronchopulmonary dysplasia

2020 ◽  
Vol 319 (3) ◽  
pp. L576-L584
Author(s):  
Craig A. Gelfand ◽  
Reiko Sakurai ◽  
Ying Wang ◽  
Yitian Liu ◽  
Robert Segal ◽  
...  
Keyword(s):  
Lung Injury ◽  
Vitamin A ◽  
Bronchopulmonary Dysplasia ◽  
Rat Model ◽  
Serum Vitamin ◽  
Surfactant Protein ◽  
Lung Damage ◽  
Neonatal Rat ◽  
Preterm Neonates ◽  
Neonatal Rat Model

Prevention of bronchopulmonary dysplasia (BPD) in premature-birth babies continues to be an unmet medical need. Intramuscular vitamin A is currently employed in preterm neonates to prevent BPD but requires intramuscular injections in fragile neonates. We hypothesized that noninvasive inhaled delivery of vitamin A, targeted to lung, would be a more effective and tolerable strategy. We employed our well-established hyperoxia-injury neonatal rat model, exposing newborn rats to 7 days of constant extreme (95% O2) hyperoxia, comparing vitamin A dosed every 48 h via either aerosol inhalation or intramuscular injection with normoxic untreated healthy animals and vehicle-inhalation hyperoxia groups as positive and negative controls, respectively. Separately, similar vitamin A dosing of normoxia-dwelling animals was performed. Analyses after day 7 included characterization of alveolar histomorphology and protein biomarkers of alveolar maturation [surfactant protein C (SP-C), peroxisome proliferator-activated receptor (PPAR) γ, cholinephosphate cytidylyl transferase, vascular endothelial growth factor and its receptor, FLK-1, and retinoid X receptors (RXR-α, -β, and -γ], apoptosis (Bcl2 and Bax) key injury repair pathway data including protein markers (ALK-5 and β-catenin) and neutrophil infiltration, and serum vitamin A levels. Compared with intramuscular dosing, inhaled vitamin A significantly enhanced biomarkers of alveolar maturation, mitigated hyperoxia-induced lung damage, and enhanced surfactant protein levels, suggesting that it may be more efficacious in preventing BPD in extremely premature infants than the traditionally used IM dosing regimen. We speculate lung-targeted inhaled vitamin A may also be an effective therapy against other lung damaging conditions leading to BPD or, more generally, to acute lung injury.

scholarly journals Antioxidant effects of N-acetylcysteine in a neonatal rat model of necrotizing enterocolitis

2012 ◽  
Vol 47 (9) ◽  
pp. 1652-1657 ◽  
Author(s):  
Ramazan Ozdemir ◽  
Sadık Yurttutan ◽  
Fatma Nur Sarı ◽  
Bulent Uysal ◽  
Hatice Germen Unverdi ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Rat Model ◽  
Neonatal Rat ◽  
Antioxidant Effects ◽  
Neonatal Rat Model
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