scholarly journals TARC/CCL17 gene polymorphisms and expression associated with susceptibility and coronary artery aneurysm formation in Kawasaki disease

2013 ◽  
Vol 74 (5) ◽  
pp. 545-551 ◽  
Author(s):  
Chiu-Ping Lee ◽  
Ying-Hsien Huang ◽  
Yu-Wen Hsu ◽  
Kuender D. Yang ◽  
Hsu-Chen Chien ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Gene Polymorphisms ◽  
Coronary Artery Aneurysm ◽  
Artery Aneurysm ◽  
Aneurysm Formation

scholarly journals An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Yunfeng Liu ◽  
Lanyan Fu ◽  
Lei Pi ◽  
Di Che ◽  
Yufen Xu ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Gene Polymorphism ◽  
Gene Polymorphisms ◽  
Coronary Artery Aneurysm ◽  
Artery Aneurysm ◽  
Chinese Children ◽  
Southern Chinese ◽  
A Genome ◽  
Agt Gene

Background. Kawasaki disease (KD) is an acute vasculitis disease that commonly causes acquired heart disease in children. Coronary artery aneurysm (CAA) is a major complication of KD. However, the pathogenesis of KD remains unclear. The results of a genome-wide association study (GWAS) showed that two functional single-nucleotide polymorphisms (SNPs; rs699A>G and rs5050T>G) in the angiotensinogen (AGT) gene were related to cardiovascular disease susceptibility. The purpose of our study was to estimate the relationship between the two GWAS-identified AGT gene polymorphisms and the risk of CAA in Southern Chinese children with KD. Methods. We genotyped the two AGT gene polymorphisms (rs699A>G and rs5050T>G) in 760 KD cases and 972 healthy controls. We used the odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the degree of the associations. Results. These two AGT gene polymorphisms were not associated with a risk of KD relative to the controls, but after adjusting for sex and age, the carriers of the rs5050G allele with TG/GG vs TT had an adjusted OR=1.56, 95% CI=1.01-2.41, and P=0.044 relative to the carriers of the rs5050TT genotype. The susceptibility to CAA was more predominant in KD patients younger than 12 months old. Conclusions. Our results indicate that the AGT gene polymorphism rs5050T>G may increase the risk of CAA in children with KD, especially those who are younger than 12 months. These results need to be verified by a validation study with a larger sample size.

Genetic variations within the PSORS1 region affect Kawasaki disease development and coronary artery aneurysm formation

BioMedicine ◽  
2013 ◽  
Vol 3 (2) ◽  
pp. 73-81 ◽  
Author(s):  
Wei-Yong Lin ◽  
Hsin-Ping Liu ◽  
Jeng-Sheng Chang ◽  
Ying-Ju Lin ◽  
Lei Wan ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Coronary Artery Aneurysm ◽  
Artery Aneurysm ◽  
Genetic Variations ◽  
Disease Development ◽  
Aneurysm Formation

scholarly journals Matrix metalloproteinase haplotypes associated with coronary artery aneurysm formation in patients with Kawasaki disease

2010 ◽  
Vol 55 (12) ◽  
pp. 779-784 ◽  
Author(s):  
Chisato Shimizu ◽  
Tomoyo Matsubara ◽  
Yoshihiro Onouchi ◽  
Sonia Jain ◽  
Shelly Sun ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Matrix Metalloproteinase ◽  
Coronary Artery Aneurysm ◽  
Artery Aneurysm ◽  
Aneurysm Formation
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