scholarly journals Propofol administration to the fetal–maternal unit reduces cardiac injury in late-preterm lambs subjected to severe prenatal asphyxia and cardiac arrest

2013 ◽  
Vol 73 (1-4) ◽  
pp. 427-434 ◽  
Author(s):  
Matthias Seehase ◽  
Patrick Houthuizen ◽  
Reint K. Jellema ◽  
Jennifer J.P. Collins ◽  
Otto Bekers ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Cardiac Injury ◽  
Late Preterm ◽  
Prenatal Asphyxia

scholarly journals Propofol administration to the fetal-maternal unit preserved cardiac function in late-preterm lambs subjected to severe prenatal asphyxia and cardiac arrest

2014 ◽  
Vol 1 (Suppl 1) ◽  
pp. A1
Author(s):  
Matthias Seehase ◽  
Patrick Houthuizen ◽  
Reint K Jellema ◽  
Jennifer JP Collins ◽  
Otto Bekers ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Cardiac Function ◽  
Late Preterm ◽  
Prenatal Asphyxia

scholarly journals Cardiac arrest without physical cardiac injury during Nuss repair of pectus excavatum

2017 ◽  
Vol 12 (1) ◽  
Author(s):  
Jianyong Zou ◽  
Canqiao Luo ◽  
Zhenguo Liu ◽  
Chao Cheng
Keyword(s):  
Cardiac Arrest ◽  
Pectus Excavatum ◽  
Cardiac Injury

scholarly journals OUTCOMES OF PENETRATING CARDIAC INJURIES – A CARDIAC SURGEON APPROACH TO 22 CASES

2021 ◽  
Vol 8 (4) ◽  
pp. 213-218
Author(s):  
Ali Cemal Duzgun ◽  
Ekin Ilkeli
Keyword(s):  
Cardiac Arrest ◽  
Cardiac Injury ◽  
Vital Signs ◽  
Trauma Patients ◽  
Cardiac Trauma ◽  
Mortality And Morbidity ◽  
Initial Intervention ◽  
Gun Shot ◽  
Cardiac Surgeon ◽  
Time Of Admission

Aim: Cardiac traumas are of great danger as they have life threatening potential. Although the patient may have normal vital signs at the time of admission the rate of mortality rate has been reported up to 69%. We believe that conducting the initial evaluation and early intervention by a cardiac surgeon may have an impact on decreased mortality. Material and methods: This study has been conducted with 22 patients that have been admitted with cardiac trauma history. The subjects who were operated after applying to emergency service have been enrolled in this retrospective analysis. İndividuals died due to cardiac arrest at admission have been excluded from the study. The subjects with penetrating cardiac injury who have undergone sternotomy or thoracotomy has been included in the analysis. Results: At the time of admission 4 patients has been presented with shock and 2 patients had been administered resuscitation due to cardiac arrest. The gun shot wound cases were 27% (n=6) and of these cases 3 of them were alive while the remaining 3 died. The stab wound cases were 73% (n=16) withh a higher survival rate of 75% (n=4/16). Thoracotomy has been conducted less than sternotomy as the rate was 13.6% (n=3) versus 86.4% (n=19). The overall rate of mortality has been found as 32% (n=7). Conclusıon: According to the results of this study one can say that conducting initial intervention to cardiac trauma patients by a cardiac surgeon reduced the rate of mortality and morbidity.

scholarly journals Severe COVID-19 pneumonia complicated by cardiomyopathy and a small anterior pneumothorax

2021 ◽  
Vol 14 (9) ◽  
pp. e245900
Author(s):  
Rajkumar Rajendram ◽  
Arif Hussain
Keyword(s):  
Cardiac Arrest ◽  
Respiratory Failure ◽  
Transthoracic Echocardiography ◽  
Gold Standard ◽  
Lung Ultrasound ◽  
Cardiac Injury ◽  
X Rays ◽  
Lateral Decubitus ◽  
High Index Of Suspicion ◽  
Symptoms And Signs

Although, cardiac injury, pneumothorax and pneumomediastinum are associated with COVID-19, differentiation of their symptoms and signs from those of COVID-19 itself is challenging. Without a high index of suspicion, cardiomyopathy and anterior pneumothorax are easily missed. These complications may be underdiagnosed in patients with COVID-19. Cardiomyopathy and pneumothorax may cause or exacerbate respiratory failure. If their management is delayed, cardiac arrest can occur. To increase the awareness of these issues, we describe the course and imaging of a 39-year-old woman with severe COVID-19 who developed cardiomyopathy and a small anterior pneumothorax with pneumomediastinum. Transthoracic echocardiography is technically challenging in the presence of anterior pneumothorax. Furthermore, although CT is the gold standard for the diagnosis of pneumothorax, this is not always feasible in critically ill patients. Lateral decubitus chest X-rays and lung ultrasound may facilitate the diagnosis of pneumothorax at the bedside of patients with COVID-19.

Cardiac Injury: Severe blunt chest trauma leads to cardiac arrest

2008 ◽  
Vol 33 (8) ◽  
pp. 36-36
Author(s):  
William Whalen ◽  
Daniel Holena ◽  
John P. Pryor
Keyword(s):  
Cardiac Arrest ◽  
Blunt Chest Trauma ◽  
Chest Trauma ◽  
Cardiac Injury

THE EFFECT OF IMMATURITY AND PRENATAL ASPHYXIA ON THE LUNGS AND PULMONARY FUNCTION OF NEWBORN LAMBS: THE EXPERIMENTAL PRODUCTION OF RESPIRATORY DISTRESS

PEDIATRICS ◽  
1965 ◽  
Vol 35 (3) ◽  
pp. 382-392
Author(s):  
E. O. R. Reynolds ◽  
H. N. Jacobson ◽  
E. K. Motoyama ◽  
Y. Kikkawa, ◽  
J. M. Craig ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Gas Exchange ◽  
Pulmonary Function ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Human Infant ◽  
Experimental Production ◽  
Comparable Control ◽  
Prenatal Asphyxia ◽  
Experimental Disease

1. The effect of immaturity on the lungs and pulmonary function of newborn lambs was assessed by delivering and observing 13 animals of varying gestational ages. In lambs of approximately 125-129 days gestation changes closely resembling those of human respiratory distress syndrome developed without asphyxia. These changes consisted of retraction of the chest wall, poor gas exchange, grossly liver-like lungs, reduced pulmonary surface activity, and, on histological examination, severe atelectasis, alveolar necrosis, and hyaline membranes. 2. Similar changes were found in 4 of 6 lambs subjected to severe prenatal asphyxia lasting for up to 4 hours which were between approximately 130-136 days gestation but not in three of four comparable control animals. 3. Prolonged prenatal asphyxia was followed by changes suggesting respiratory distress in only 1 of 6 lambs above 136 days gestation. One further lamb at 140 days gestation, acutely asphyxiated to the point of cardiac arrest, developed severe changes. 4. It is postulated that the experimental disease and the syndrome seen in the human infant are produced by similar mechanisms, and that the influence of prematurity is more important than that of asphyxia.

scholarly journals Penetrating cardiac injury repaired under “intentional cardiac arrest” with adenosine triphosphate

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Kazuki Hagiwara ◽  
Jun‐ichi Inoue ◽  
Gaku Matumoto ◽  
Fumiaki Iwase
Keyword(s):  
Cardiac Arrest ◽  
Adenosine Triphosphate ◽  
Cardiac Injury ◽  
Penetrating Cardiac Injury

scholarly journals Cardiac complications and pertaining mortality rate in COVID-19 patients; a systematic review and meta-analysis

2020 ◽  
Author(s):  
Amirmohammad Toloui ◽  
Donya Moshrefiaraghi ◽  
Arian Madani Neishaboori ◽  
Saeed Safari ◽  
Mahmoud Yousefifard ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Cardiac Arrest ◽  
Mortality Rate ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Cardiac Injury ◽  
Cardiac Complications ◽  
Troponin Level ◽  
Patient Assessments

Abstract Background Raising knowledge over cardiac complications and managing them can play a key role in their recovery. In this study, we aim to investigate the evidence regarding the prevalence of cardiac complications and the resulting mortality rate in COVID-19 patients. Results The initial search resulted in 853 records, from which 40 articles were included. Overall analysis showed the prevalence of acute cardiac injury, heart failure and cardiac arrest were 19.46% (95% CI: 18.23–20.72), 19.07% (95% CI: 15.38–23.04) and 3.44% (95% CI: 3.08–3.82), respectively. Moreover, abnormal serum troponin level was observed in 22.86% (95% CI: 21.19–24.56) of the COVID-19 patients. Further analysis revealed that the overall odds of mortality is 14.24 [odds ratio (OR) = 14.24; 95% CI: 8.67–23.38] times higher, when patients develop acute cardiac injury. The pooled odds ratio of mortality when the analysis was limited to abnormal serum troponin level was 19.03 (OR = 19.03; 95% CI: 11.85–30.56). Conclusion Acute cardiac injury and abnormal serum troponin level were the most prevalent cardiac complications/abnormalities in COVID-19 patients. The importance of cardiac complications becomes crucial due to the higher mortality rate among patients with these complications. Thus, troponin screenings and cardiac evaluations are recommended to be performed in routine patient assessments.

scholarly journals Propofol administration to the fetal–maternal unit reduces cardiac oxidative stress in preterm lambs subjected to prenatal asphyxia and cardiac arrest

2016 ◽  
Vol 79 (5) ◽  
pp. 748-753 ◽  
Author(s):  
Matthias Seehase ◽  
Patrick Houthuizen ◽  
Jennifer J. P. Collins ◽  
Luc J. Zimmermann ◽  
Boris W. Kramer
Keyword(s):  
Oxidative Stress ◽  
Cardiac Arrest ◽  
Prenatal Asphyxia

scholarly journals Tocilizumab reduces cardiac injury after out-of-hospital cardiac arrest primarily in patients without acute revascularization - Results from a randomized trial, The IMICA trial

2021 ◽  
Vol 10 (Supplement_1) ◽  
Author(s):  
M Meyer ◽  
S Wiberg ◽  
J Grand ◽  
ASP Meyer ◽  
L Obling ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Systemic Inflammation ◽  
Marked Reduction ◽  
Myocardial Dysfunction ◽  
Geometric Mean ◽  
Cardiac Injury ◽  
Temperature Management ◽  
Significant Group ◽  
Biomarker Analysis ◽  
Hospital Cardiac Arrest

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): The Danish Heart Foundation (Reference no. 19-R135-A9302-22125) Lundbeck Foundation (Reference no. R186-2015-2132) BACKGROUND Patients remaining comatose after the initial resuscitation from out-of-hospital cardiac arrest (OHCA) have a high risk of morbidity and mortality as part of the ensuing post cardiac arrest syndrome (PCAS). Systemic inflammation and myocardial dysfunction are constituents of PCAS. The cytokine Interleukin-6 (IL-6) is associated with PCAS severity and poor outcome. Also, the extend of cardiac injury is a prognostic marker. We have recently shown that the IL-6 receptor antagonist tocilizumab dampens systemic inflammation and cardiac injury after cardiac arrest. PURPOSE To investigate if the reduction in cardiac injury by tocilizumab is differentiated in patients undergoing acute coronary revascularization compared to those who do not. METHODS Eighty comatose OHCA patients were randomized 1:1 in a double-blinded placebo-controlled trial to a single infusion of tocilizumab or placebo in addition to standard of care including targeted temperature management. Trial registration: Clinicaltrials.gov NCT03863015. Blood samples were sequentially drawn for biomarker analysis. Endpoints were markers of cardiac injury and inflammation:  Troponin T (TnT), N-terminal pro B-type natriuretic peptide (NT-proBNP), and C-reactive protein (CRP). Continuous variables were log2 transformed and analyzed using mixed models; values shown as geometric mean with 95%-confidence limits [95%CL] after back-transformation. RESULTS Thirty-nine patients were randomized to treatment with tocilizumab and 41 to placebo. In the tocilizumab group 15 (39%) patients underwent acute revascularization (all PCI), and this was 22 (54%) for placebo. Patients not undergoing acute revascularization had a marked reduction by treatment with tocilizumab in TnT at 6h, as well as NT-proBNP at 48h (Figure). For patients treated with acute revascularization there was no significant group difference in TnT at 6h, whereas there was a marked reduction in NT-proBNP at 48h. There was a substantial reduction in CRP by treatment with tocilizumab irrespective of whether acute revascularization was performed. CONCLUSION Treatment with tocilizumab resulted in a significant reduction in myocardial injury as measured by TnT primarily in patients not undergoing acute revascularization, whereas the reduction in NT-proBNP, as well as CRP, was seen irrespective of whether acute revascularization was performed. Abstract Figure. Acute vs. NO acute revascularization

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