scholarly journals Effect of inborn vs. outborn delivery on neurodevelopmental outcomes in infants with hypoxic–ischemic encephalopathy: secondary analyses of the NICHD whole-body cooling trial

2012 ◽  
Vol 72 (4) ◽  
pp. 414-419 ◽  
Author(s):  
Girija Natarajan ◽  
Athina Pappas ◽  
Seetha Shankaran ◽  
Abbot R. Laptook ◽  
Michele Walsh ◽  
...  
Keyword(s):  
Hypoxic Ischemic Encephalopathy ◽  
Whole Body ◽  
Neurodevelopmental Outcomes ◽  
Secondary Analyses ◽  
Body Cooling ◽  
Whole Body Cooling ◽  
Ischemic Encephalopathy

The Use of Whole Body Cooling in the Treatment of Hypoxic-Ischemic Encephalopathy

2017 ◽  
Vol 36 (5) ◽  
pp. 273-279 ◽  
Author(s):  
Tiffany Harriman ◽  
Wanda T. Bradshaw ◽  
Stephanie M. Blake
Keyword(s):  
English Language ◽  
Current Treatment ◽  
Hypoxic Ischemic Encephalopathy ◽  
Whole Body ◽  
Neurodevelopmental Outcomes ◽  
Near Term ◽  
Body Cooling ◽  
Whole Body Cooling ◽  
Ischemic Encephalopathy

AbstractHypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in neonates. Hypoxic-ischemic encephalopathy occurs as a result of a perinatal hypoxic-ischemic event just prior to or during delivery. Therapeutic hypothermia using whole body cooling is the current treatment of choice to reduce brain injury and improve long-term neurodevelopmental outcomes for neonates with HIE. All English language articles published since 2005 in PubMed and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) were analyzed for existing evidence-based methods for whole body cooling. Whole body cooling is effective in the treatment of HIE in term and near-term neonates. Further research is needed to investigate the use of adjunctive therapies in conjunction with whole body cooling for improved neuroprotection.

Prophylactic Phenobarbital and Whole-Body Cooling for Neonatal Hypoxic-Ischemic Encephalopathy

2010 ◽  
Vol 157 (2) ◽  
pp. 334-336 ◽  
Author(s):  
Donald F. Meyn ◽  
Jayne Ness ◽  
Namasivayam Ambalavanan ◽  
Waldemar A. Carlo
Keyword(s):  
Hypoxic Ischemic Encephalopathy ◽  
Whole Body ◽  
Body Cooling ◽  
Whole Body Cooling ◽  
Ischemic Encephalopathy

scholarly journals Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling

2011 ◽  
Vol 205 (3) ◽  
pp. 251.e1-251.e7 ◽  
Author(s):  
Christopher S. Ennen ◽  
Thierry A.G.M. Huisman ◽  
William J. Savage ◽  
Frances J. Northington ◽  
Jacky M. Jennings ◽  
...  
Keyword(s):  
Glial Fibrillary Acidic Protein ◽  
Acidic Protein ◽  
Hypoxic Ischemic Encephalopathy ◽  
Whole Body ◽  
Body Cooling ◽  
Whole Body Cooling ◽  
Ischemic Encephalopathy

scholarly journals Comparison of selective head cooling therapy and whole body cooling therapy in newborns with hypoxic ischemic encephalopathy: Short term results

2015 ◽  
Vol 50 (1) ◽  
pp. 27-36 ◽  
Author(s):  
Aytug Atici ◽  
Yalcin Celik ◽  
Selvi Gulasi ◽  
Ali Haydar Turhan ◽  
Cetin Okuyaz ◽  
...  
Keyword(s):  
Hypoxic Ischemic Encephalopathy ◽  
Whole Body ◽  
Short Term ◽  
Head Cooling ◽  
Body Cooling ◽  
Whole Body Cooling ◽  
Ischemic Encephalopathy

Selective Head versus Whole Body Cooling Treatment of Hypoxic-Ischemic Encephalopathy: Comparison of Electroencephalogram and Magnetic Resonance Imaging Findings

2019 ◽  
Vol 37 (12) ◽  
pp. 1264-1270
Author(s):  
Ajay Goenka ◽  
Elissa Yozawitz ◽  
William A. Gomes ◽  
Suhas M. Nafday
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Brain Magnetic Resonance Imaging ◽  
Hypoxic Ischemic Encephalopathy ◽  
Whole Body ◽  
Resonance Imaging ◽  
Eeg Abnormalities ◽  
Body Cooling ◽  
Whole Body Cooling ◽  
Ischemic Encephalopathy

Abstract Objective This study aimed to compare the utility of electroencephalogram (EEG) and brain magnetic resonance imaging (MRI) to detect brain dysfunction and injury across a cohort of newborn infants treated with selective head cooling (SHC) or whole body cooling (WBC). Study Design Therapeutic hypothermia (TH) is a standard neuroprotection tool for hypoxic-ischemic encephalopathy (HIE) in neonates. Sixty-six newborns, SHC (n = 22) and WBC (n = 44), were studied utilizing standardized scoring systems for interpretation of EEG and MRI based on the severity of the findings. Results SHC- and WBC-treated groups did not differ significantly amongst most of the baseline parameters. EEGs obtained postcooling were abnormal in 58 of 61 (95%) infants. The severity of the EEG background changes (depressed and undifferentiated background) was more prevalent in the SHC (8/21 [38%]) than in the WBC group (5/40 [13%]). Brain MRIs showed HIE changes in 26 of 62 (42%) newborns treated with TH. MRI abnormalities of basal ganglia, thalamic, and parenchymal lesions were more common in the SHC (5/19) versus the WBC group (3/43); p = 0.04. Conclusion EEG abnormalities and MRI findings of HIE were more prevalent in the SHC than in the WBC group. WBC may offer better or at least similar neuroprotection to infants with HIE.

Subcutaneous fat necrosis, a rare but serious side effect of hypoxic-ischemic encephalopathy and whole-body hypothermia

2019 ◽  
Vol 47 (9) ◽  
pp. 986-990 ◽  
Author(s):  
Mahdi Alsaleem ◽  
Lina Saadeh ◽  
Valerie Elberson ◽  
Vasantha H.S. Kumar
Keyword(s):  
Therapeutic Hypothermia ◽  
Subcutaneous Fat ◽  
Whole Body ◽  
Subcutaneous Fat Necrosis ◽  
P Values ◽  
Life Threatening ◽  
The Mean ◽  
Body Cooling ◽  
Whole Body Cooling ◽  
Ischemic Encephalopathy

Abstract Objective To describe the clinical characteristics and risk factors in infants with subcutaneous fat necrosis (SFN) following therapeutic hypothermia for hypoxic-ischemic encephalopathy (HIE). Methods A case-control study was performed by a retrospective chart review of infants with moderate or severe HIE admitted to a level IV regional perinatal center and who underwent whole-body cooling. Results A total of 14 (8.1%) of 171 infants with moderate or severe HIE who underwent whole-body cooling developed SFN during hospitalization. There were more females [71% (10/14)] and large-for-gestational age (LGA) infants [28% (4/14)] in the SFN group vs. 36% females (57/157) and 8% LGA infants (13/157) in the group without SFN (P-values of 0.009 and 0.015, respectively). The mean lowest platelet count was lower 108 ± 55 109/L vs. 146 ± 62 109/L and the mean highest calcium level was higher 11.3 ± 2.5 vs. 10.6 ± 0.8 mg/dL in infants with SFN vs. infants without SFN, respectively (P-values of 0.0078 and 0.006, respectively). Distribution of skin lesions followed distinctive patterns representing the areas with direct contact with the cooling blanket. One infant developed severe, life-threatening hypercalcemia that required aggressive management, including diuretics, corticosteroids and bisphosphonates. Conclusion Although SFN is a rare complication of therapeutic hypothermia, it can be a life-threatening condition if complicated by severe hypercalcemia. Infants who undergo therapeutic hypothermia for HIE need regular skin examinations to evaluate for SFN. If SFN is identified, monitoring of serum calcium levels to prevent life-threatening hypercalcemia is recommended.

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