scholarly journals Allele-Specific Glycosylation of ILE131THR Variant Retards Surfactant Protein B Processing and Secretion: Basis of Predisposition to Respiratory Distress Syndrome

2011 ◽  
Vol 70 ◽  
pp. 656-656 ◽  
Author(s):  
J Huusko ◽  
S Taponen ◽  
U E Petäjä-Repo ◽  
R Paananen ◽  
S H Guttentag ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Surfactant Protein ◽  
Surfactant Protein B ◽  
Allele Specific ◽  
Protein B

scholarly journals Dinucleotide repeats in the human surfactant protein-B gene and respiratory-distress syndrome

1995 ◽  
Vol 305 (2) ◽  
pp. 583-590 ◽  
Author(s):  
J Floros ◽  
S V Veletza ◽  
P Kotikalapudi ◽  
L Krizkova ◽  
A M Karinch ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Surfactant Protein ◽  
Normal Lung ◽  
Dinucleotide Repeats ◽  
Conserved Sequence ◽  
Surfactant Protein B ◽  
Genomic Dnas ◽  
Protein B

Pulmonary surfactant, a lipoprotein complex, is essential for normal lung function, and deficiency of surfactant can result in respiratory-distress syndrome (RDS) in the prematurely born infant. Some studies have pointed towards a genetic contribution to the aetiology of RDS. Because the surfactant protein B (SP-B) is important for optimal surfactant function and because it is involved in the pathogenesis of pulmonary disease, we investigated the genetic variability of the SP-B gene in individuals with and without RDS. We identified a 2.5 kb BamHI polymorphism and studied its location, nature and frequency. We localized this polymorphism in the first half of intron 4 and found that it is derived by gain or loss in the number of copies of a motif that consists of two elements, a 20 bp conserved sequence and a variable number of CA dinucleotides. Variability in the number of motifs resulting from either deletion (in 55.3% of the cases with the variation) or insertion (44.7%) of motifs was observed in genomic DNAs from unrelated individuals. Analysis of 219 genomic DNAs from infants with (n = 82) and without (n = 137) RDS showed that this insertion/deletion appears with significantly higher frequency in the RDS population (29.3 as against 16.8%, P < 0.05).

Surfactant protein B polymorphism and respiratory distress syndrome in premature twins

2003 ◽  
Vol 112 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Riitta Marttila ◽  
Ritva Haataja ◽  
Mika Rämet ◽  
Johan Löfgren ◽  
Mikko Hallman
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Surfactant Protein ◽  
Surfactant Protein B ◽  
Protein B

DIMERIC SURFACTANT PROTEIN B PEPTIDE SP-B 1-25 IN NEONATAL AND ACUTE RESPIRATORY DISTRESS SYNDROME

2002 ◽  
Vol 28 (8) ◽  
pp. 623-640 ◽  
Author(s):  
Frans J. Walther ◽  
José M. Hernandez-Juviel ◽  
Larry M. Gordon ◽  
Mark A. Sherman ◽  
Alan J. Waring
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Surfactant Protein ◽  
Surfactant Protein B ◽  
Dimeric Surfactant ◽  
Protein B

scholarly journals Surfactant protein-B polymorphisms and mortality in the acute respiratory distress syndrome*

2008 ◽  
Vol 36 (9) ◽  
pp. 2511-2516 ◽  
Author(s):  
Paul F. Currier ◽  
Michelle N. Gong ◽  
Rihong Zhai ◽  
Lucille J. Pothier ◽  
Paul D. Boyce ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Surfactant Protein ◽  
Surfactant Protein B ◽  
Protein B
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