scholarly journals Evolution of In-Vitro Sensitisation to Cow's Milk Proteins Among Preterm Infants with Necrotising Enterocolitis

2011 ◽  
Vol 70 ◽  
pp. 598-598
Author(s):  
A E Abdelhamid ◽  
S -L Chuang ◽  
P Hays ◽  
J Fell
Keyword(s):  
Preterm Infants ◽  
Milk Proteins ◽  
Necrotising Enterocolitis ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Cow’S Milk Proteins

scholarly journals Effects of pH Variation and NaCl on In Vitro Digestibility of Cow's Milk Proteins in Commercially Available Infant Formulas.

2000 ◽  
Vol 46 (6) ◽  
pp. 325-328 ◽  
Author(s):  
Kentaro SAKAI ◽  
Kenji YOSHINO ◽  
Mohammed A. SATTER ◽  
Fusao OTA ◽  
Yoshitaka NII ◽  
...  
Keyword(s):  
Milk Proteins ◽  
Cow’S Milk ◽  
In Vitro Digestibility ◽  
Infant Formulas ◽  
Ph Variation ◽  
Cow's Milk ◽  
Effects Of Ph ◽  
Cow’S Milk Proteins

Soy Formula Doesn't Help Colic

PEDIATRICS ◽  
1983 ◽  
Vol 71 (2) ◽  
pp. 299-300
Author(s):  
LASSE LOTHE ◽  
TOR LINDBERG ◽  
IRÉNE JAKOBSSON
Keyword(s):  
Adverse Reaction ◽  
Soy Protein ◽  
Milk Proteins ◽  
Cow’S Milk ◽  
Milk Formula ◽  
Cow's Milk ◽  
Cow’S Milk Proteins

In Reply.— We fully agree with LeBlanc that there was no significant improvement when infants with colic were given a soy protein-based formula. As pointed out in the "Discussion," as many as 53% of the infants showed an adverse reaction to soy (corresponding figure for cow's milk formula was 71%). We also emphasized that these figures must be interpreted with caution. In fact, soy protein-based formula was a bad choice as placebo. A placebo substance should be a substance of no importance as an allergen in infancy and soy protein has been shown to be as antigenic as cow's milk proteins (Eastham EJ, et al: J Pediatr 1978;93:561).

ALLERGENIC ACTIVITY AND DANGER OF INDUSTRIAL DUSTS OF DRY PRODUCTS OF COW'S MILK PROCESSING

2021 ◽  
pp. 51-55
Author(s):  
Baranov S.A. ◽  
◽  
Shevlyakov V.V. ◽  
Sychyk S.I. ◽  
Filonyuk V.A. ◽  
...  
Keyword(s):  
Milk Proteins ◽  
The Body ◽  
Cow’S Milk ◽  
Antigenic Determinants ◽  
Allergic Reactions ◽  
Cow's Milk ◽  
Milk Processing ◽  
Allergenic Activity

The purpose of the work was to establish in a model experiment the allergenic activity and danger of the extracts obtained from the dust of dry products of cow's milk processing (DPMP), containing complexes of soluble whey (WMP) or casein milk proteins (CMP), as a stage of hygienic regulation of the content of dust DPMP in the air of the working area. Experiments on albino guinea pigs sensitized by the intradermal injection of standard doses of WMP and СМР solutions into the ear revealed the development of severe allergic reactions in the animals of the experimental groups with the prevalence of mixed mechanisms of immediate anaphylactic and delayed cell-mediated types. According to the criteria for the classification of industrial allergens, the WMP and СМР complexes have a strong allergenic activity and are differentiated to the 1-st class of allergenic hazard, which determines the classification of the DPMP dust containing them as extremely dangerous industrial allergens. This is confirmed by the established high levels of indicators of allergic-diagnostic reactions in vivo and in vitro when testing sensitized WMP and СМР animals with a solution of skim milk powder dust, indicating the presence of antigenic determinants of whey and casein milk proteins in it and a real ability to form cross-allergic reactions in the body of workers to dust from all dry milk processing products containing these proteins.

scholarly journals ЕФЕКТИВНІСТЬ ЕЛІМІНАЦІЙНОЇ ДІЄТИ У ДІТЕЙ ГРУДНОГО ВІКУ З ГАСТРОІНТЕСТИНАЛЬНИМИ ПРОЯВАМИ ХАРЧОВОЇ АЛЕРГІЇ

2019 ◽  
pp. 16-21
Author(s):  
Гайдучик Г. А.
Keyword(s):  
Milk Proteins ◽  
Diet Therapy ◽  
Elimination Diet ◽  
Cow’S Milk ◽  
Complete Regression ◽  
Cationic Protein ◽  
Cow's Milk ◽  
Skin Symptoms ◽  
Gastrointestinal Food Allergy ◽  
Cow’S Milk Proteins

The purpose of the work was to evaluate the effectiveness of the elimination diet in infants with gastrointestinal manifestations of food allergy.Patients and methods. 84 children aged 2 months to 1 year were examined with gastrointestinal food allergy to cow's milk proteins. All children were prescribed an elimination diet with the exclusion of cow's milk proteins. An assessment was made of the regression of gastrointestinal symptoms on day 3, 7 and 14 of diet therapy and the determination of the concentration of eosinophilic cationic protein in serum. The general-clinical, immunological, allergological and statistical methods of research were used.Results. The purpose of the elimination diet with the exclusion of cow's milk proteins for nursing mothers and the use of mixtures with extensive hydrolysis of protein in the case of artificial feeding leads to a complete regression of gastrointestinal and skin symptoms in all examined children on the 14th day of diet therapy, which is further confirmed by the normalization of the concentration of eosinophilic cationic serum protein in diet therapy. Conclusions. Elimination of cow's milk proteins in infants with gastrointestinal food allergy results in complete regression of gastrointestinal and skin symptoms on day 14 of diet therapy, and determination of the concentration of eosinophilic cationic protein in serum can be used as an additional criterion for the effectiveness of diet therapy.

scholarly journals Eosinophilic esophagitis after induction of oral tolerance for cow’s milk proteins

2013 ◽  
Vol 3 (S3) ◽  
Author(s):  
C Muñoz Archidona ◽  
JF Viada Bris ◽  
SJ Quevedo Teruel ◽  
S Fernández Fernández ◽  
AI Rayo Fernández ◽  
...  
Keyword(s):  
Eosinophilic Esophagitis ◽  
Oral Tolerance ◽  
Milk Proteins ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Cow’S Milk Proteins

scholarly journals Safety of oral immunotherapy in addition to omalizumab in patients with severe allergy to cow's milk proteins

2019 ◽  
Vol 143 (2) ◽  
pp. AB276
Author(s):  
Laura Feijoo Paz ◽  
Ruth Maria Barranco ◽  
Jesus F. Fernandez Crespo ◽  
Maria Del Carmen Dieguez
Keyword(s):  
Milk Proteins ◽  
Oral Immunotherapy ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Cow’S Milk Proteins

scholarly journals Effect of Low-Immunogenic Yogurt Drinks and Probiotic Bacteria on Immunoreactivity of Cow’s Milk Proteins and Tolerance Induction—In Vitro and In Vivo Studies

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3390
Author(s):  
Barbara Wróblewska ◽  
Anna Kaliszewska-Suchodoła ◽  
Ewa Fuc ◽  
Lidia Hanna Markiewicz ◽  
Anna Maria Ogrodowczyk ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Tolerance Induction ◽  
Milk Proteins ◽  
In Vivo Studies ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Safe Product

There is no effective therapy for milk allergy. The role of lactic acid bacteria (LAB) and probiotics in protection against allergy-related outcomes is still under investigation. The aim of the study was to evaluate the immunomodulative and therapeutic potential of yogurt drinks in cow’s milk allergy (CMA) management. We compared immunoreactivity of α-casein (α-CN), β-casein (β-CN), κ-casein (κ-CN), α-lactalbumin (α-LA), and β-lactoglobulin (β-LG) in 27 yogurt drinks fermented with different basic yogurt cultures, or yogurt cultures enriched with Lactobacillus plantarum and/or Bifidobacterium lactis strains, by competitive ELISA assay. Drinks with the lowest antigenic potential were used as allergoids for CMA therapy. BALB/c mice were sensitized via intraperitoneal injection of α-CN + β-LG mixture with aluminum adjuvant, and gavaged with increasing doses of selected low-immunogenic drinks (YM—basic, or YM-LB—enriched with L. plantarum and B. lactis) to induce tolerance. Milk- or phosphate-buffered saline (PBS)-dosed mice served as controls. Compared to milk, the immunoreactivity of proteins in drinks increased or decreased, depending on the bacterial sets applied for fermentation. Only a few sets acted synergistically in reducing immunoreactivity. The selected low-immunogenic drinks stimulated allergic mice for profiling Th2 to Th1 response and acquire tolerance, and the effect was greater with YM-LB drink, which during long-lasting interventional feeding strongly increased the secretion of regulatory cytokines, i.e., IL-10 and TGF-β, and IgA and decreased IL-4, IgE, and anti-(α-CN + β-LG) IgG1. The studies revealed variations in the potency of yogurt bacteria to change allergenicity of milk proteins and the need for their strict selection to obtain a safe product for allergy sufferers. The YM-LB drink with reduced antigenic potential may be a source of allergoids used in the immunotherapy of IgE mediated CMA, but further clinical or volunteer studies are required.

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