scholarly journals Patent Ductus Arteriosus Ligation in Premature Infants: Unproven Long Term Benefit at the Cost of Short Term Morbidities?

2011 ◽  
Vol 70 ◽  
pp. 280-280
Author(s):  
B Sinha ◽  
B Balahara ◽  
A Fujii ◽  
S A Ringer
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Short Term ◽  
The Cost ◽  
Term Benefit ◽  
Patent Ductus

Renal Calcifications: A Complication of Long-Term Furosemide Therapy in Preterm Infants

PEDIATRICS ◽  
1982 ◽  
Vol 70 (3) ◽  
pp. 360-363 ◽  
Author(s):  
Karen G. Hufnagle ◽  
Shadid N. Khan ◽  
Duna Penn ◽  
Alexander Cacciarelli ◽  
Paul Williams
Keyword(s):  
Calcium Phosphate ◽  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Chronic Lung Disease ◽  
Stone Formation ◽  
Ductus Arteriosus ◽  
Probable Mechanism ◽  
Calcium Excretion ◽  
Patent Ductus

During the last four years ten premature infants developed renal calcifications while receiving long-term furosemide therapy. The drug was used in infants with patent ductus arteriosus and later in the same infants with chronic lung disease. They had received furosemide in a dose of at least 2 mg/kg/day for at least 12 days before calcifications were noted on abdominal roentgenograms. Calcifications included small flecks, isolated stones, staghorn calculi, and nephrocalcinosis. Analysis of stones received from four infants showed calcium oxalate and calcium phosphate. Infants who were not receiving furosemide had no calcifications. The infants with renal calcifications had rates of calcium excretion ten to 20 times that of normal, age-matched premature infants in our nursery. When chlorothiazide was given to the infants, in addition to furosemide, a four- to 15-fold decrease in calcium excretion and a radiologic dissolution of the renal calcifications were documented. It is concluded that furosemide, in doses of at least 2 mg/kg/day for at least 12 days can be associated with renal calcifications. The probable mechanism of the stone formation is hypercalciuria, primarily caused by furosemide.

Patent Ductus Arteriosus and Short- and Long-Term Respiratory Outcomes

2016 ◽  
Vol 33 (11) ◽  
pp. 1055-1057 ◽  
Author(s):  
Eduardo Bancalari
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Pulmonary Blood Flow ◽  
Ductus Arteriosus ◽  
Lung Damage ◽  
Early Closure ◽  
Short And Long Term ◽  
Respiratory Outcomes ◽  
Patent Ductus

The patency of the ductus arteriosus is very common in extremely premature infants. The increased pulmonary blood flow that results from left-to-right ductal shunting can produce an acute deterioration in lung function and some data suggest that it may increase the risk of chronic lung damage. However, there is no clear evidence that prophylactic or early closure of the patent ductus arteriosus (PDA) results in a clear reduction in bronchopulmonary dysplasia. For this reason, and because of the side effects of the available therapies to close the ductus, there is a wide variation in the approach to the PDA in this population and most clinicians will intervene to close the ductus only in cases of significant shunt with hemodynamic decompensation.

scholarly journals Long-term Results of Ligation of Patent Ductus Arteriosus in Premature Infants.

1992 ◽  
Vol 21 (1) ◽  
pp. 35-40
Author(s):  
Tohru SAKURADA ◽  
Ryosei KURIBAYASHI ◽  
Satoshi SEKINE ◽  
Hiroaki AIDA ◽  
Keiji SEKI ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Long Term Results ◽  
Patent Ductus

scholarly journals Management of Patent Ductus Arteriosus in Premature Infants in 2020

2021 ◽  
Vol 8 ◽  
Author(s):  
Sarah Parkerson ◽  
Ranjit Philip ◽  
Ajay Talati ◽  
Shyam Sathanandam
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Paradigm Shift ◽  
Ductus Arteriosus ◽  
Cardiac Condition ◽  
Practice Variations ◽  
Patent Ductus

The patent ductus arteriosus (PDA) is the most commonly found cardiac condition in neonates. While there have been several studies and thousands of publications on the topic, the decision to treat the PDA is still strongly debated among cardiologists, surgeons, and neonatologists. This is in part due to the shortage of long-term benefits with the interventions studied. Practice variations still exist within sub-specialties and centers. This article briefly summarizes the history, embryology and histology of the PDA. It also succinctly discusses the hemodynamic significance of a PDA which builds the framework to review all the available literature on PDA closure in premature infants, though not a paradigm shift just yet; it introduces transcatheter PDA closure (TCPC) as a possible armament to the clinician for this age-old problem.

scholarly journals Pulmonary Hypertension with Prolonged Patency of the Ductus Arteriosus in Preterm Infants

Children ◽  
2020 ◽  
Vol 7 (9) ◽  
pp. 139
Author(s):  
Ranjit Philip ◽  
Vineet Lamba ◽  
Ajay Talati ◽  
Shyam Sathanandam
Keyword(s):  
Decision Making ◽  
Pulmonary Hypertension ◽  
Preterm Infants ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Pulmonary Vasculature ◽  
Short Term ◽  
Diagnostic Cardiac Catheterization ◽  
Patent Ductus

There continues to be a reluctance to close the patent ductus arteriosus (PDA) in premature infants. The debate on whether the short-term outcomes translate to a difference in long-term benefits remains. This article intends to review the pulmonary vasculature changes that can occur with a chronic hemodynamically significant PDA in a preterm infant. It also explains the rationale and decision-making involved in a diagnostic cardiac catheterization and transcatheter PDA closure in these preterm infants.

Short-Term Complications Associated with Surgical Ligation of Patent Ductus Arteriosus in ELBW Infants: A 25-Year Cohort Study

2019 ◽  
Author(s):  
Megan Foster ◽  
Lea H. Mallett ◽  
Vinayak Govande ◽  
Niraj Vora ◽  
Abel Castro ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Length Of Stay ◽  
Patent Ductus Arteriosus ◽  
Gestational Age ◽  
Surgical Complication ◽  
Ductus Arteriosus ◽  
Short Term ◽  
Patent Ductus

Abstract Objective This article aims to determine the incidence of short-term complications of surgical patent ductus arteriosus (PDA) ligations, the factors associated with those complications, and whether complications are associated with poor long-term outcomes. Study Design Retrospective cohort study of all extremely low birth weight (ELBW, < 1,000 g) infants who underwent surgical PDA ligation at a single-center neonatal intensive care unit from 1989 to 2015. Demographic, clinical, and laboratory data were reviewed. The primary outcome was development of a short-term (< 2 weeks from ligation) surgical complication. Secondary outcomes include bronchopulmonary dysplasia (BPD), length of stay, and mortality. Results A total of 180 ELBW infants were included; median gestational age and birth weight was 24 weeks and 683 g, respectively, and 44% of infants had at least one short-term complication. Need for vasopressors (33%) was the most common medical complication and vocal cord paralysis (9%) was the most common surgical complication. Younger corrected gestational age at time of repair was associated with increased risk for complications. Mortality, length of stay, and BPD rates were similar between infants with and without complications. Conclusion Serious complications were seen in a minority of infants. Additional research is needed to determine if short-term complications are associated with long-term adverse outcomes.

scholarly journals Oral paracetamol versus oral ibuprofen for treatment of patent ductus arteriosus

2017 ◽  
Vol 46 (2) ◽  
pp. 811-818 ◽  
Author(s):  
Manar Al-lawama ◽  
Iyad Alammori ◽  
Tariq Abdelghani ◽  
Eman Badran
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Primary Closure ◽  
Ductus Arteriosus ◽  
Randomized Study ◽  
Inclusion Criteria ◽  
Short Term ◽  
Significant Difference ◽  
Oral Ibuprofen ◽  
Patent Ductus

Objective This study was performed to investigate the safety and efficacy of oral paracetamol versus oral ibuprofen in the treatment of patent ductus arteriosus (PDA) in premature infants. Methods Premature infants with PDA with a gestational age of ≤32 weeks or birth weight of ≤1500 g were included in this randomized study. Results A total of 120 premature infants fulfilled the inclusion criteria. Of these 120 infants, 34 fulfilled the treatment criteria and 22 were finally randomized. We found no significant difference in the mortality or primary closure rates between the two groups. We also found no significant difference in the short-term neonatal outcomes. Conclusions Either oral paracetamol or oral ibuprofen can be used safely and effectively to treat PDA in premature infants.

Late manifestation coarctation of the aorta in a premature infant 4-month post-percutaneous device closure of a patent ductus arteriosus

2019 ◽  
Vol 29 (12) ◽  
pp. 1556-1558
Author(s):  
Ryan M. Serrano ◽  
Mark D. Rodefeld ◽  
Ryan Alexy
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Coarctation Of The Aorta ◽  
Percutaneous Closure ◽  
Device Closure ◽  
Percutaneous Device ◽  
Favourable Safety ◽  
Patent Ductus

AbstractPatent ductus arteriosus is the most common cardiovascular abnormality in premature infants. With newly available percutaneous devices, centres are reporting high rates of success and favourable safety profiles with percutaneous closure of haemodynamically significant ductus arteriosi in infants under 1000 g. We report the case of a 5-week-old, previous 25-week gestation, 1200-g infant who underwent successful percutaneous closure of a ductus arteriosus with a Medtronic Microvascular Plug but who developed late-term coarctation from the device. This case should prompt practitioners to consider the need and timing of follow-up echocardiograms in this population and sheds light on a newly reported long-term complication of device closure in premature infants.

ASSOCIATION OF PATENT DUCTUS ARTERIOSUS SIZE WITH CLINICAL FEATURES AND SHORT-TERM OUTCOMES IN PRETERM INFANTS LESS THAN 34 WEEKS

2020 ◽  
Vol 07 (03) ◽  
pp. 105-108
Author(s):  
Chandrakala Bada Shekharappa ◽  
Edison Albert Balakrishnan Elizabeth ◽  
Bharathi Balachander
Keyword(s):  
Patent Ductus Arteriosus ◽  
Preterm Infants ◽  
Clinical Features ◽  
Ductus Arteriosus ◽  
Short Term ◽  
Patent Ductus
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