scholarly journals Differences in Human Milk (HM) Consumption Based on Discharge Diet During Nicu Hospitalization of Very Low Birth Weight (VLBW) Infants

2011 ◽  
Vol 70 ◽  
pp. 781-781
Author(s):  
H Bigger ◽  
L Fogg ◽  
J Engstrom ◽  
P Meier
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Very Low Birth Weight ◽  
Vlbw Infants

scholarly journals The Potential Effects of Human Milk on Morbidity in Very-Low-Birth-Weight Preterm Infants

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1882
Author(s):  
Paola Roggero ◽  
Nadia Liotto ◽  
Orsola Amato ◽  
Fabio Mosca
Keyword(s):  
Quality Of Care ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Preterm Infants ◽  
Very Low Birth Weight ◽  
Mortality And Morbidity ◽  
Vlbw Infants

Improvements in quality of care have led to a significant reduction in mortality and morbidity in preterm infants, especially very-low-birth-weight (VLBW) infants [...]

scholarly journals Growth and nutrient intake among very-low-birth-weight infants fed fortified human milk during hospitalisation

2009 ◽  
Vol 102 (8) ◽  
pp. 1179-1186 ◽  
Author(s):  
Christine Henriksen ◽  
Ane C. Westerberg ◽  
Arild Rønnestad ◽  
Britt Nakstad ◽  
Marit B. Veierød ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Preterm Infants ◽  
Nutrient Intake ◽  
Very Low Birth Weight ◽  
Growth Restriction ◽  
Vlbw Infants ◽  
Uterine Growth ◽  
Discharge From Hospital

Postnatal growth failure in preterm infants is due to interactions between genetic and environmental factors, which are not fully understood. We assessed dietary supply of nutrients in very-low-birth-weight (VLBW, < 1500 g) infants fed fortified human milk, and examined the association between nutrient intake, medical factors and growth during hospitalisation lasting on average 70 d. We studied 127 VLBW infants during the early neonatal period. Data were obtained from medical records on nutrient intake, growth and growth-related factors. Extra-uterine growth restriction was defined as body weight < 10th percentile of the predicted value at discharge. Using logistic regression, we evaluated nutrient intake and other relevant factors associated with extra-uterine growth restriction in the subgroup of VLBW infants with adequate weight for gestational age at birth. The proportion of growth restriction was 33 % at birth and increased to 58 % at discharge from hospital. Recommended values for energy intake (>500 kJ/kg per d) and intra-uterine growth rate (15 g/kg per d) were not met, neither in the period from birth to 28 weeks post-conceptional age (PCA), nor from 37 weeks PCA to discharge. Factors negatively associated with growth restriction were energy intake (Ptrend = 0·002), non-Caucasian ethnicity (P = 0·04) and weight/predicted birth weight at birth (Ptrend = 0·004). Extra-uterine growth restriction is common in VLBW infants fed primarily fortified human milk. Currently recommended energy and nutrient intake for growing preterm infants was not achieved. Reduced energy supply and non-Caucasian ethnicity were risk factors for growth restriction at discharge from hospital.

scholarly journals Dose-dependent effect of human milk on Bronchopulmonary dysplasia in very low birth weight infants

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yan Xu ◽  
Zhangbin Yu ◽  
Qianqian Li ◽  
Jinjun Zhou ◽  
Xiaoguang Yin ◽  
...  
Keyword(s):  
Quality Improvement ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Very Low Birth Weight ◽  
Research Database ◽  
Vlbw Infants ◽  
Dose Dependent

Abstract Background and aim Human milk has potential protective effects against bronchopulmonary dysplasia (BPD). However, studies on the association between the dose of human milk and BPD in China are limited. This study aimed to evaluate the dose-dependent effects of human milk on BPD and other neonatal morbidities in very low birth weight (VLBW) infants. Methods This retrospective cohort study of preterm infants was conducted on preterm infants of gestational age ≤ 34 weeks and birth weight < 1500 g admitted to the multicenter clinical research database for breastfeeding quality improvement in Jiangsu province. The multivariate analysis was performed to compare the effect outcomes of daily graded doses [1–24 mL/(kg · day), 25–49 mL/(kg · day), and ≥ 50 mL/(kg · day) of body weight] of human milk on neonatal outcomes throughout the first 4 weeks of life versus a reference group receiving no human milk. The models were adjusted for potential confounding variables. Results Of 964 included infants, 279 (28.9%) received exclusive preterm formula, 128 (13.3%) received 1–24 ml/(kg · day), 139 (14.4%) received 25–49 ml/(kg · day), and 418 (43.4%) received ≥50 ml/(kg · day) human milk for the first 4 weeks of life. Compared with infants receiving exclusive formula, those receiving the highest volume of human milk daily [≥50 mL/(kg · day)] had lower incidences of BPD [27.5% in ≥50 mL/(kg · day) vs 40.1% in 0 mL/(kg · day) human milk, P = 0.001)], moderate and severe BPD [8.9% in ≥50 mL/(kg · day) vs 16.1% in 0 mL/(kg · day), P = 0.004], necrotizing enterocolitis [NEC; 3.8% in ≥50 mL/(kg · day) vs 10.8% in 0 mL/(kg · day), P = 0.001], late-onset sepsis [LOS; 9.3% in ≥50 mL/(kg · day) vs 19.7% in 0 mL/(kg · day), P <0.01], and extrauterine growth retardation [EUGR; 38.5% in ≥50 mL/(kg · day) vs 57.6% in 0 mL/(kg · day), P <0.01)]. The logistic regression indicated that those receiving ≥50 ml/kg · day human milk had lower odds of BPD [adjusted odds ratio (AOR) 0.453; 95% confidence interval (CI): 0.309, 0.666], moderate and severe BPD (AOR 0.430; 95% CI: 0.249, 0.742), NEC (AOR 0.314; 95% CI: 0.162, 0. 607), LOS (AOR 0.420; 95% CI: 0.263, 0.673), and EUGR (AOR 0.685; 95% CI: 0.479, 0.979). Conclusions A daily threshold amount of ≥50 ml/(kg · day) human milk in the first 4 weeks of life was associated with lower incidence of BPD as well as NEC, LOS, and EUGR in VLBW infants. Trial registration ClinicalTrials.gov Identifier: NCT03453502. Registration date: March 5, 2018. This study was retrospectively registered.

An Observational Study on Effect of High Human Milk Intake on Oxidative Status of VLBW Infants

2021 ◽  
Vol 104 (3) ◽  
pp. 370-374
Keyword(s):  
Oxidative Stress ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Antioxidant Capacity ◽  
Very Low Birth Weight ◽  
Oxidative Status ◽  
Milk Intake ◽  
Vlbw Infants ◽  
Total Antioxidant

Background: Preterm infants are at high risk of oxidative stress injuries from various conditions such as low antioxidant capacity, relatively hyperoxia state outside utero, and possible immaturity of many organs. Human milk is an ideal nutrition and medication for these infants. It has antioxidative effects from both enzymatic and non-enzymatic constituents. Objective: To evaluate the beneficial effects of human milk on oxidative status and antioxidant capacity in very-low birth weight infants. Materials and Methods: The present research was a prospective cohort study conducted between January and December 2017. Preterm birthweight less than 1,500 grams were enrolled. Infants were divided into two groups based on breastmilk intake proportion, more than 50% or less than 50% of milk intake. Oxidative status was assessed using plasma malondialdehyde (MDA), and total antioxidant status (TAS) was assessed using Trolox equivalent antioxidant capacity (TEAC). Results: Nineteen (19) VLBW infants were enrolled. Six infants (32%) were in low breastmilk intake group and 13 infants (68%) received breastmilk 50% or more of total enteral intake. Plasma MDA at D1, D7, and D28 were 6.49±5.76, 9.49±6.77, and 6.96±4.84 μM in the low breastmilk intake group, and 8.68±4.44, 8.82±5.01, and 5.71±2.74 in the high breastmilk intake group (p>0.05). Plasma TAS at D1, D7, and D28 were 4.06±0.87, 6.73±2.07, and 7.59±2.03 mmol of Trolox equivalence/L in the low breastmilk intake group, and 8.2±1.55, 7.4±2.29, and 6.58±1.9 mmol of Trolox equivalence/L in the high breastmilk intake group (p>0.05). There was no difference in patient characteristics regarding gender, gestational age, birthweight, mode of delivery, surfactant use, duration of mechanical ventilation, or duration of oxygen supplementation. Conclusion: The present study was unable to demonstrate the differences of plasma MDA and total antioxidant capacity in VLBW infants. Therefore, further studies using more sensitive markers were suggested. Keywords: VLBW, Very low birth weight, Preterm, Oxidative stress, Human milk

scholarly journals HUMAN MILK FEEDINGS AND INFECTION AMONG VERY LOW BIRTH WEIGHT (VLBW) INFANTS.▴ 1757

1996 ◽  
Vol 39 ◽  
pp. 295-295 ◽  
Author(s):  
Mary Ann Hylander ◽  
Donna M Strobino ◽  
Ramasubbareddy Dhanireddy
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Very Low Birth Weight ◽  
Vlbw Infants

Reduced Formula Intake with Donor Milk (DM) Impacts Necrotizing Enterocolitis (NEC) in Very Low Birth Weight (VLBW) Infants:

PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 443A-443A
Author(s):  
Jennifer S. Wicks ◽  
Anita L. Esquerra-Zwiers ◽  
Laura M. Rogers ◽  
Celina M. Scala ◽  
Shirley Chen ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Necrotizing Enterocolitis ◽  
Very Low Birth Weight ◽  
Donor Milk ◽  
Vlbw Infants

scholarly journals Sex-Specific Long-Term Trends in Length of Hospital Stay, Postmenstrual Age at Discharge, and Survival in Very Low Birth Weight Infants

Neonatology ◽  
2021 ◽  
pp. 1-9
Author(s):  
Matthias Fröhlich ◽  
Tatjana Tissen-Diabaté ◽  
Christoph Bührer ◽  
Stephanie Roll
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Hospital Stay ◽  
Very Low Birth Weight ◽  
Survival Rates ◽  
Length Of Hospital Stay ◽  
Mortality Rates ◽  
Vlbw Infants ◽  
Postmenstrual Age ◽  
Over Time

<b><i>Introduction:</i></b> In very low birth weight (&#x3c;1,500 g, VLBW) infants, morbidity and mortality have decreased substantially during the past decades, and both are known to be lower in girls than in boys. In this study, we assessed sex-specific changes over time in length of hospital stay (LOHS) and postmenstrual age at discharge (PAD), in addition to survival in VLBW infants. <b><i>Methods:</i></b> This is a single-center retrospective cohort analysis based on quality assurance data of VLBW infants born from 1978 to 2018. Estimation of sex-specific LOHS over time was based on infants discharged home from neonatal care or deceased. Estimation of sex-specific PAD over time was based on infants discharged home exclusively. Analysis of in-hospital survival was performed for all VLBW infants. <b><i>Results:</i></b> In 4,336 of 4,499 VLBW infants admitted from 1978 to 2018 with complete data (96.4%), survival rates improved between 1978–1982 and 1993–1997 (70.8 vs. 88.3%; hazard ratio (HR) 0.20, 95% confidence interval 0.14, 0.30) and remained stable thereafter. Boys had consistently higher mortality rates than girls (15 vs. 12%, HR 1.23 [1.05, 1.45]). Nonsurviving boys died later compared to nonsurviving girls (adjusted mean survival time 23.0 [18.0, 27.9] vs. 20.7 [15.0, 26.3] days). LOHS and PAD assessed in 3,166 survivors displayed a continuous decrease over time (1978–1982 vs. 2013–2018: LOHS days 82.9 [79.3, 86.5] vs. 60.3 [58.4, 62.1] days); PAD 40.4 (39.9, 40.9) vs. 37.4 [37.1, 37.6] weeks). Girls had shorter LOHS than boys (69.4 [68.0, 70.8] vs. 73.0 [71.6, 74.4] days) and were discharged with lower PAD (38.6 [38.4, 38.8] vs. 39.2 [39.0, 39.4] weeks). <b><i>Discussion/Conclusions:</i></b> LOHS and PAD decreased over the last 40 years, while survival rates improved. Male sex was associated with longer LOHS, higher PAD, and higher mortality rates.

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