scholarly journals XRCC1 Arg399Gln and Arg194Trp polymorphisms in prostate cancer risk: a meta-analysis

2011 ◽  
Vol 14 (3) ◽  
pp. 225-231 ◽  
Author(s):  
B Wei ◽  
Y Zhou ◽  
Z Xu ◽  
J Ruan ◽  
M Zhu ◽  
...  
2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Jie Yan ◽  
Xiantao Wang ◽  
Hui Tao ◽  
Zengfu Deng ◽  
Wang Yang ◽  
...  

Abstract Prostate cancer is one of the most common noncutaneous malignancies in Western countries. Because there has been a debate regarding the relationship between the XRCC1-Arg399Gln and Arg280His polymorphisms and prostate cancer risk, we therefore performed this meta-analysis. The electronic databases PubMed, EMBASE and Medline were searched prior to October 1, 2014. An odds ratio and 95% confidence interval were used to calculate association. Heterogeneity was tested by both a chi-square test and I2statistic. Funnel plots and Egger’s test were used to assess publication bias. All statistical analyses were performed using STATA 12.0 software. A significant association between the XRCC1-Arg399Gln polymorphism and prostate cancer risk was found under a homozygote model and a recessive model. A significant association between XRCC1-Arg280His and prostate cancer risk was found under a heterozygote model and a dominant model. Overall, the results of this meta-analysis show that the XRCC1-Arg399Gln polymorphism may be associated with an increased risk for prostate cancer under the homozygote model and the recessive model. And XRCC1-Arg280His polymorphism is likely to be related with prostate cancer risk under the heterozygote model and the dominant model. Additional larger well-designed studies are needed to validate our results.


2015 ◽  
Vol 67 (3) ◽  
pp. 392-400 ◽  
Author(s):  
Huan Liu ◽  
Guang-Hui Hu ◽  
Xing-Chun Wang ◽  
Tian-Bao Huang ◽  
Liang Xu ◽  
...  

2016 ◽  
Vol Volume 9 ◽  
pp. 4163-4171 ◽  
Author(s):  
Yong Xu ◽  
Yungkai Qie ◽  
Xuewu Nian ◽  
Xuesen Liu ◽  
Hailong Hu ◽  
...  

2012 ◽  
Vol 14 (4) ◽  
pp. 560-565 ◽  
Author(s):  
Jie Yang ◽  
Dong-Liang Xu ◽  
Qiang Lu ◽  
Zhi-Jian Han ◽  
Jun Tao ◽  
...  

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0206249 ◽  
Author(s):  
Xian Zhang ◽  
Yi Lin ◽  
Xiaoning Xie ◽  
Meiya Shen ◽  
Guoping Huang ◽  
...  

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Zheng-Ju Ren ◽  
De-Hong Cao ◽  
Qin Zhang ◽  
Peng-Wei Ren ◽  
Liang-Ren Liu ◽  
...  

2017 ◽  
Vol 19 (6) ◽  
pp. 666 ◽  
Author(s):  
Lu Yang ◽  
Qiang Wei ◽  
Ping Tan ◽  
Chen Zhang ◽  
Shi-You Wei ◽  
...  

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