Cancer-associated fibroblasts induce cancer cell apoptosis that regulates invasion mode of tumours

Oncogene ◽  
2017 ◽  
Vol 36 (31) ◽  
pp. 4434-4444 ◽  
Author(s):  
G Itoh ◽  
S Chida ◽  
K Yanagihara ◽  
M Yashiro ◽  
N Aiba ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cancer Associated Fibroblasts ◽  
Cancer Cell Apoptosis ◽  
Induce Cancer Cell Apoptosis

Facile synthesis of highly uniform selenium nanoparticles using glucose as the reductant and surface decorator to induce cancer cell apoptosis

2016 ◽  
Vol 4 (13) ◽  
pp. 2351-2358 ◽  
Author(s):  
Tianqi Nie ◽  
Hualian Wu ◽  
Ka-Hing Wong ◽  
Tianfeng Chen
Keyword(s):  
Mitochondrial Dysfunction ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Selenium Nanoparticles ◽  
Facile Synthesis ◽  
Cancer Cell Apoptosis ◽  
Intracellular Ros ◽  
Induction Of Apoptosis ◽  
Highly Uniform ◽  
Induce Cancer Cell Apoptosis

Herein, we demonstrated a new and facial synthesis of highly uniformed SeNPs using glucose as the reductant and surface decorator. Glu–SeNPs induced cancer cell apoptosisviainduction of apoptosis by triggering intracellular ROS overproduction and mitochondrial dysfunction.

Photothermal and photodynamic therapy reagents based on rGO–C6H4–COOH

RSC Advances ◽  
2016 ◽  
Vol 6 (5) ◽  
pp. 3748-3755 ◽  
Author(s):  
Guangcheng Wei ◽  
Miaomiao Yan ◽  
Liying Ma ◽  
Chunhua Wang
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cancer Cell Apoptosis ◽  
Induce Cancer Cell Apoptosis

A photothermal and photodynamic therapy reagent based on rGO–C6H4–COOH was developed, which could effectively induce cancer cell apoptosis.

Anti-hepatoma activity of the stiff branched β-d-glucan and effects of molecular weight

2016 ◽  
Vol 4 (26) ◽  
pp. 4565-4573 ◽  
Author(s):  
Zhaohua Ping ◽  
Hui Xu ◽  
Ting Liu ◽  
Junchao Huang ◽  
Yan Meng ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Immune Responses ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Water Soluble ◽  
Auricularia Auricula ◽  
Cancer Cell Apoptosis ◽  
Induce Cancer Cell Apoptosis

The water soluble β-d-glucan AF1 with short branches isolated from Auricularia auricula-judae exhibited significant anti-hepatoma activities, and it was confirmed that AF1 had stiff chains and could induce cancer cell apoptosis and anti-angiogenesis through activating immune responses.

Lupane triterpenes with a carbonyl group at C-20 induce cancer cell apoptosis

2008 ◽  
Vol 62 (3) ◽  
pp. 332-335 ◽  
Author(s):  
Keishi Hata ◽  
Shoujiro Ogawa ◽  
Mitsuko Makino ◽  
Toshiyuki Mukaiyama ◽  
Kazuyuki Hori ◽  
...  
Keyword(s):  
Carbonyl Group ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cancer Cell Apoptosis ◽  
Lupane Triterpenes ◽  
Induce Cancer Cell Apoptosis

scholarly journals Exploiting poly(I:C) to induce cancer cell apoptosis

2017 ◽  
Vol 18 (10) ◽  
pp. 747-756 ◽  
Author(s):  
Francesca Bianchi ◽  
Samantha Pretto ◽  
Elda Tagliabue ◽  
Andrea Balsari ◽  
Lucia Sfondrini
Keyword(s):  
Cancer Cell ◽  
Cell Apoptosis ◽  
Poly I:C ◽  
Cancer Cell Apoptosis ◽  
Induce Cancer Cell Apoptosis

scholarly journals Histone methyltransferase WHSC1 inhibits colorectal cancer cell apoptosis via targeting anti-apoptotic BCL2

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yu Wang ◽  
Liming Zhu ◽  
Mei Guo ◽  
Gang Sun ◽  
Kun Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
B Cell Lymphoma ◽  
Histone Methyltransferase ◽  
Chemotherapeutic Agents ◽  
Cancer Cell Apoptosis ◽  
Active Transcription

AbstractWHSC1 is a histone methyltransferase that facilitates histone H3 lysine 36 dimethylation (H3K36me2), which is a permissive mark associated with active transcription. In this study, we revealed how WHSC1 regulates tumorigenesis and chemosensitivity of colorectal cancer (CRC). Our data showed that WHSC1 as well as H3K36me2 were highly expressed in clinical CRC samples, and high WHSC1 expression is associated with poorer prognosis in CRC patients. WHSC1 reduction promoted colon cancer cell apoptosis both in vivo and in vitro. We found that B cell lymphoma-2 (BCL2) expression, an anti-apoptotic protein, is markedly decreased in after WHSC1 depletion. Mechanistic characterization indicated that WHSC1 directly binds to the promoter region of BCL2 gene and regulate its H3K36 dimethylation level. What’s more, our study indicated that WHSC1 depletion promotes chemosensitivity in CRC cells. Together, our results suggested that WHSC1 and H3K36me2 modification might be optimal therapeutic targets to disrupt CRC progression and WHSC1-targeted therapy might potentially overcome the resistance of chemotherapeutic agents.

Saccharomyces cerevisiae may serve as a probiotic in colorectal cancer by promoting cancer cell apoptosis

2020 ◽  
Vol 21 (10) ◽  
pp. 571-582
Author(s):  
Jia Qi Li ◽  
Jia Lu Li ◽  
Yuan Hong Xie ◽  
Yao Wang ◽  
Xiao Nan Shen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Saccharomyces Cerevisiae ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cancer Cell Apoptosis
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