scholarly journals Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion

Oncogene ◽  
2016 ◽  
Vol 35 (40) ◽  
pp. 5263-5271 ◽  
Author(s):  
T T Vellinga ◽  
S den Uil ◽  
I H B Rinkes ◽  
D Marvin ◽  
B Ponsioen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Colon Tumors

scholarly journals Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis

Oncogene ◽  
2004 ◽  
Vol 23 (27) ◽  
pp. 4681-4689 ◽  
Author(s):  
Sajani S Lakka ◽  
Christopher S Gondi ◽  
Niranjan Yanamandra ◽  
William C Olivero ◽  
Dzung H Dinh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rna Interference ◽  
Tumor Growth ◽  
Tumor Cell ◽  
Cell Line ◽  
Cell Invasion ◽  
Cathepsin B ◽  
Tumor Cell Invasion ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell

scholarly journals AP-1 Differentially Expressed Proteins Krp1 and Fibronectin Cooperatively Enhance Rho-ROCK-Independent Mesenchymal Invasion by Altering the Function, Localization, and Activity of Nondifferentially Expressed Proteins

2006 ◽  
Vol 26 (4) ◽  
pp. 1480-1495 ◽  
Author(s):  
Heather J. Spence ◽  
Lynn McGarry ◽  
Catherine S. Chew ◽  
Neil O. Carragher ◽  
Linda A. Scott-Carragher ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Tumor Cell ◽  
Cell Invasion ◽  
Essential Role ◽  
Differentially Expressed ◽  
Tumor Cell Invasion ◽  
Actin Binding ◽  
Fibroblast Cells ◽  
Differentially Expressed Proteins

ABSTRACT The transcription factor AP-1, which is composed of Fos and Jun family proteins, plays an essential role in tumor cell invasion by altering gene expression. We report here that Krp1, the AP-1 up-regulated protein that has a role in pseudopodial elongation in v-Fos-transformed rat fibroblast cells, forms a novel interaction with the nondifferentially expressed actin binding protein Lasp-1. Krp1 and Lasp-1 colocalize with actin at the tips of pseudopodia, and this localization is maintained by continued AP-1 mediated down-regulation of fibronectin that in turn suppresses integrin and Rho-ROCK signaling and allows pseudopodial protrusion and mesenchyme-like invasion. Mutation analysis of Lasp-1 demonstrates that its SH3 domain is necessary for pseudopodial extension and invasion. The results support the concept of an AP-1-regulated multigenic invasion program in which proteins encoded by differentially expressed genes direct the function, localization, and activity of proteins that are not differentially expressed to enhance the invasiveness of cells.

CUTL1–a modulator of tumor cell invasion and target of TGF-beta which is highly expressed in colon cancer

2004 ◽  
Vol 42 (08) ◽  
Author(s):  
P Michl ◽  
M Ei'Bahrawy ◽  
R Poulsom ◽  
A Ramjaun ◽  
J Downward
Keyword(s):  
Colon Cancer ◽  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Tgf Beta
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