scholarly journals FOXM1 allows human keratinocytes to bypass the oncogene-induced differentiation checkpoint in response to gain of MYC or loss of p53

Oncogene ◽  
2016 ◽  
Vol 36 (7) ◽  
pp. 956-965 ◽  
Author(s):  
R Molinuevo ◽  
A Freije ◽  
I de Pedro ◽  
S W Stoll ◽  
J T Elder ◽  
...  
Keyword(s):  
Human Keratinocytes ◽  
Induced Differentiation

scholarly journals Human epidermal stem cell differentiation is modulated by specific lipid subspecies

2020 ◽  
Vol 117 (36) ◽  
pp. 22173-22182
Author(s):  
Matteo Vietri Rudan ◽  
Ajay Mishra ◽  
Christian Klose ◽  
Ulrike S. Eggert ◽  
Fiona M. Watt
Keyword(s):  
Stem Cell ◽  
Stem Cell Differentiation ◽  
Human Keratinocytes ◽  
Epidermal Differentiation ◽  
Keratinocyte Differentiation ◽  
Fatty Acid Transport ◽  
Epidermal Stem Cell ◽  
Primary Human Keratinocytes ◽  
Induced Differentiation ◽  
Lipid Species

While the lipids of the outer layers of mammalian epidermis and their contribution to barrier formation have been extensively described, the role of individual lipid species in the onset of keratinocyte differentiation remains unknown. A lipidomic analysis of primary human keratinocytes revealed accumulation of numerous lipid species during suspension-induced differentiation. A small interfering RNA screen of 258 lipid-modifying enzymes identified two genes that on knockdown induced epidermal differentiation:ELOVL1, encoding elongation of very long-chain fatty acids protein 1, andSLC27A1, encoding fatty acid transport protein 1. By intersecting lipidomic datasets from suspension-induced differentiation and knockdown keratinocytes, we pinpointed candidate bioactive lipid subspecies as differentiation regulators. Several of these—ceramides and glucosylceramides—induced differentiation when added to primary keratinocytes in culture. Our results reveal the potential of lipid subspecies to regulate exit from the epidermal stem cell compartment.

scholarly journals Inhibition of Serum- and Calcium-Induced Differentiation of Human Keratinocytes by HPV16 E6 Oncoprotein: Role of p53 Inactivation

Virology ◽  
1997 ◽  
Vol 237 (2) ◽  
pp. 296-306 ◽  
Author(s):  
Levana Sherman ◽  
Anna Jackman ◽  
Hagar Itzhaki ◽  
Melissa Conrad Stöppler ◽  
Debbie Koval ◽  
...  
Keyword(s):  
Human Keratinocytes ◽  
Induced Differentiation ◽  
Hpv16 E6 ◽  
E6 Oncoprotein ◽  
P53 Inactivation

Chemical-Induced Differentiation of Cultured Human Keratinocytes as Measured by Cell Size Distribution

1990 ◽  
pp. 307-311
Author(s):  
Frank Van Pelt ◽  
Marion Stelling ◽  
Ine Hassing ◽  
Ruud Van De Heijden ◽  
Bas Blaauboer
Keyword(s):  
Size Distribution ◽  
Cell Size ◽  
Human Keratinocytes ◽  
Induced Differentiation ◽  
Cell Size Distribution
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