scholarly journals YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression

Oncogene ◽  
2015 ◽  
Vol 34 (50) ◽  
pp. 6040-6054 ◽  
Author(s):  
C He ◽  
X Lv ◽  
G Hua ◽  
S M Lele ◽  
S Remmenga ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Initiation ◽  
Autocrine Loops

scholarly journals miR-93-5p Suppresses Ovarian Cancer Malignancy and Negatively Regulate CCND2 By Binding To Its 3’UTR Region

2021 ◽  
Author(s):  
Guotong Chen ◽  
Yiwei Yan ◽  
Xiaojv Qiu ◽  
Chengfeng Ye ◽  
Xingmei Jiang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Ovarian Cancer Patient ◽  
Apoptotic Cell ◽  
Gynecological Cancer ◽  
Underlying Mechanism ◽  
Bioinformatic Analysis ◽  
Cell Analysis ◽  
Wound Healing Assay ◽  
Cancer Initiation ◽  
Favorable Prognostic Factor

Abstract Ovarian cancer is the most lethal gynecological cancer worldwide, but the underlying mechanism of ovarian cancer malignancy acquirement is largely unknown. miRNA is ubiquitously implicated in disease especially in cancer initiation and progression. In current study, we firstly detected the expression level of miR-93-5p in ovarian cancer patient samples and conducted a survival analysis. Our data revealed miR-93-5p is a favorable prognostic factor but is downregulated in ovarian cancer patients. Secondly, CCK8 assay wound healing assay and flow cytometry-based cell cycle analysis and apoptotic cell analysis were performed respectively to study the function of miR-93-5p. Functional analysis show miR-93-5p promotes ovarian cancer malignancy in term of cell proliferation, migration but reduce cell death. Bioinformatic analysis showed Cyclin-D2(CCND2) is a candidate gene of miR-93-5p with the binding site in its 3’UTR region. Furthermore, quantitive-PCR and western blot were utilized to measure miR-93-5p, CCND2 levels in tissues samples and cell lines. Our data suggested miR-93-5p is negatively correlated to the level of CCND2 mRNA and protein. Finally, Luciferase report assay was conducted, and we demonstrated miR-93-5p reduces CCND2 expression by binding to the 3’UTR region. Our study revealed the function of miR-93-5p in ovarian cancer malignancy and declaimed CCND2 as a target of miR-93-5p.

scholarly journals Identification and Analysis of An Epigenetically Regulated Five-lncRNA Signature Associated With Outcome and Chemotherapy Response in Ovarian Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Hao Yang ◽  
Lin Gao ◽  
Meiling Zhang ◽  
Ning Ning ◽  
Yan Wang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cox Regression ◽  
Risk Groups ◽  
Chemotherapy Response ◽  
Epigenetic Alterations ◽  
Protein Coding ◽  
Cox Regression Analysis ◽  
Cancer Initiation ◽  
Regulation Mechanisms ◽  
Predicting Outcome

The deregulation of long non-coding RNAs (lncRNAs) by epigenetic alterations has been implicated in cancer initiation and progression. However, the epigenetically regulated lncRNAs and their association with clinical outcome and therapeutic response in ovarian cancer (OV) remain poorly investigated. This study performed an integrative analysis of DNA methylation data and transcriptome data and identified 419 lncRNAs as potential epigenetically regulated lncRNAs. Using machine-learning and multivariate Cox regression analysis methods, we identified and developed an epigenetically regulated lncRNA expression signature (EpiLncRNASig) consisting of five lncRNAs from the list of 17 epigenetically regulated lncRNAs significantly associated with outcome. The EpiLncRNASig could stratify patients into high-risk groups and low-risk groups with significantly different survival and chemotherapy response in different patient cohorts. Multivariate Cox regression analyses, after adjusted by other clinical features and treatment response, demonstrated the independence of the DEpiLncSig in predicting survival. Functional analysis for relevant protein-coding genes of the DEpiLncSig indicated enrichment of known immune-related or cancer-related biological pathways. Taken together, our study not only provides a promising prognostic biomarker for predicting outcome and chemotherapy response but also will improve our understanding of lncRNA epigenetic regulation mechanisms in OV.

scholarly journals The role of microRNAs in ovarian cancer initiation and progression

2010 ◽  
Vol 14 (9) ◽  
pp. 2240-2249 ◽  
Author(s):  
Shuang-Di Li ◽  
Jia-Rong Zhang ◽  
Yan-Qiu Wang ◽  
Xiao-Ping Wan
Keyword(s):  
Ovarian Cancer ◽  
Cancer Initiation

scholarly journals UNC-45A Is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1604
Author(s):  
Valentino Clemente ◽  
Asumi Hoshino ◽  
Joyce Meints ◽  
Mihir Shetty ◽  
Tim Starr ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Genital Tract ◽  
Reproductive Tract ◽  
Neuronal Development ◽  
Female Reproductive Tract ◽  
Ciliated Epithelium ◽  
Actomyosin Contractility ◽  
Cancer Initiation

UNC-45A (Protein unc-45 homolog A) is a cytoskeletal-associated protein with a dual and non-mutually exclusive role as a regulator of the actomyosin system and a Microtubule (MT)-destabilizing protein, which is overexpressed in human cancers including in ovarian cancer patients resistant to the MT-stabilizing drug paclitaxel. Mapping of UNC-45A in the mouse upper genital tract and central nervous system reveals its enrichment not only in highly proliferating and prone to remodeling cells, but also in microtubule-rich areas, of the ovaries and the nervous system, respectively. In both apparatuses, UNC-45A is also abundantly expressed in the ciliated epithelium. As regulators of actomyosin contractility and MT stability are essential for the physiopathology of the female reproductive tract and of neuronal development, our findings suggest that UNC-45A may have a role in ovarian cancer initiation and development as well as in neurodegeneration.

scholarly journals Abstract 5220: The role of brain-derived neurotrophic factor in ovarian cancer initiation and progression

2018 ◽  
Author(s):  
Min Kang ◽  
Kay Y. Chong ◽  
Tobias M. Hartwich ◽  
Oluwagbemisola O. Madarikan ◽  
Jonah Nucci ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Cancer Initiation

scholarly journals UNC-45A is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System

2021 ◽  
Author(s):  
Valentino Clemente ◽  
Asumi Hoshino ◽  
Joyce Meints ◽  
Mihir Shetty ◽  
Tim Starr ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Cancer Patients ◽  
Genital Tract ◽  
Reproductive Tract ◽  
Neuronal Development ◽  
Female Reproductive Tract ◽  
Ciliated Epithelium ◽  
Cancer Initiation

AbstractUNC-45A is a cytoskeletal-associated protein with a dual and non-mutually exclusive role as a regulator of the acto-myosin system and as a Microtubule (MT)-destabilizing protein. UNC-45A is overexpressed in human cancers including in ovarian cancer patients resistant to the MT-stabilizing drug Paclitaxel. Mapping of UNC-45A in the mouse upper genital tract and central nervous system reveals its enrichment in highly proliferating and prone to remodeling cells and in microtubule-rich areas of in the ovaries and in neurons respectively. In both apparatuses UNC-45A is also abundantly expressed in the ciliated epithelium. Because regulators of acto-myosin contractility and MT stability are essential for the physiopathology of the female reproductive tract and of neuronal development our findings suggest that UNC-45A may have a role in ovarian cancer initiation and development and in neurodegeneration.

Abstract B49: Effects of exercise on ovarian cancer initiation and progression

2020 ◽  
Author(s):  
Fangfang Bi ◽  
Madeline Morrisson ◽  
Sarah Cady ◽  
Alexandra Cerchia ◽  
Kevin Yang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Initiation

scholarly journals Short-form Ron is a novel determinant of ovarian cancer initiation and progression

2016 ◽  
Vol 7 (5-6) ◽  
pp. 169-181 ◽  
Author(s):  
Katherine M. Moxley ◽  
Luyao Wang ◽  
Alana L. Welm ◽  
Magdalena Bieniasz
Keyword(s):  
Ovarian Cancer ◽  
Short Form ◽  
Cancer Initiation
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