scholarly journals ELAS1-mediated inhibition of the cyclin G1–B'γ interaction promotes cancer cell apoptosis via stabilization and activation of p53

Oncogene ◽  
2015 ◽  
Vol 34 (49) ◽  
pp. 5983-5996 ◽  
Author(s):  
S Ohno ◽  
Y Naito ◽  
S Mukai ◽  
N Yabuta ◽  
H Nojima
Keyword(s):  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cancer Cell Apoptosis ◽  
Cyclin G1

scholarly journals Histone methyltransferase WHSC1 inhibits colorectal cancer cell apoptosis via targeting anti-apoptotic BCL2

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yu Wang ◽  
Liming Zhu ◽  
Mei Guo ◽  
Gang Sun ◽  
Kun Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
B Cell Lymphoma ◽  
Histone Methyltransferase ◽  
Chemotherapeutic Agents ◽  
Cancer Cell Apoptosis ◽  
Active Transcription

AbstractWHSC1 is a histone methyltransferase that facilitates histone H3 lysine 36 dimethylation (H3K36me2), which is a permissive mark associated with active transcription. In this study, we revealed how WHSC1 regulates tumorigenesis and chemosensitivity of colorectal cancer (CRC). Our data showed that WHSC1 as well as H3K36me2 were highly expressed in clinical CRC samples, and high WHSC1 expression is associated with poorer prognosis in CRC patients. WHSC1 reduction promoted colon cancer cell apoptosis both in vivo and in vitro. We found that B cell lymphoma-2 (BCL2) expression, an anti-apoptotic protein, is markedly decreased in after WHSC1 depletion. Mechanistic characterization indicated that WHSC1 directly binds to the promoter region of BCL2 gene and regulate its H3K36 dimethylation level. What’s more, our study indicated that WHSC1 depletion promotes chemosensitivity in CRC cells. Together, our results suggested that WHSC1 and H3K36me2 modification might be optimal therapeutic targets to disrupt CRC progression and WHSC1-targeted therapy might potentially overcome the resistance of chemotherapeutic agents.

Saccharomyces cerevisiae may serve as a probiotic in colorectal cancer by promoting cancer cell apoptosis

2020 ◽  
Vol 21 (10) ◽  
pp. 571-582
Author(s):  
Jia Qi Li ◽  
Jia Lu Li ◽  
Yuan Hong Xie ◽  
Yao Wang ◽  
Xiao Nan Shen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Saccharomyces Cerevisiae ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cancer Cell Apoptosis

scholarly journals Selective degradation of IKKα by autophagy is essential for arsenite-induced cancer cell apoptosis

2020 ◽  
Vol 11 (4) ◽  
Author(s):  
Qixing Tan ◽  
Shuxian Zou ◽  
Rui Jin ◽  
Yongliang Hu ◽  
Huan Xu ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Apoptosis ◽  
Selective Degradation ◽  
Cancer Cell Apoptosis

scholarly journals β-hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling

2015 ◽  
Vol 10 (6) ◽  
pp. 3434-3442 ◽  
Author(s):  
DAN LU ◽  
JING QIAN ◽  
WEI LI ◽  
QIANQIAN FENG ◽  
SHU PAN ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Mtor Signaling ◽  
Cervical Cancer Cell ◽  
Cancer Cell Apoptosis ◽  
Human Cervical Cancer Cell ◽  
Human Cervical Cancer
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