scholarly journals Interaction of MYC with host cell factor-1 is mediated by the evolutionarily conserved Myc box IV motif

Oncogene ◽  
2015 ◽  
Vol 35 (27) ◽  
pp. 3613-3618 ◽  
Author(s):  
L R Thomas ◽  
A M Foshage ◽  
A M Weissmiller ◽  
T M Popay ◽  
B C Grieb ◽  
...  
Keyword(s):  
Host Cell ◽  
Host Cell Factor ◽  
Evolutionarily Conserved ◽  
Host Cell Factor 1

scholarly journals Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway

2011 ◽  
Vol 108 (7) ◽  
pp. 2747-2752 ◽  
Author(s):  
S. Daou ◽  
N. Mashtalir ◽  
I. Hammond-Martel ◽  
H. Pak ◽  
H. Yu ◽  
...  
Keyword(s):  
Host Cell ◽  
Proteolytic Cleavage ◽  
Host Cell Factor ◽  
Host Cell Factor 1

scholarly journals Role of Host Cell Factor-1 in cell cycle regulation.

Transcription ◽  
2012 ◽  
Vol 3 (4) ◽  
pp. 187-192 ◽  
Author(s):  
Zaffer Ullah Zargar ◽  
Shweta Tyagi
Keyword(s):  
Cell Cycle ◽  
Host Cell ◽  
Cell Cycle Regulation ◽  
Host Cell Factor ◽  
Host Cell Factor 1 ◽  
Cycle Regulation

Abstract 2600: Interaction of host cell factor-1 with the oncoprotein transcription factor MYC

2019 ◽  
Author(s):  
Tessa M. Popay ◽  
Lance R. Thomas ◽  
Jing Wang ◽  
Qi Liu ◽  
William P. Tansey
Keyword(s):  
Transcription Factor ◽  
Host Cell ◽  
Host Cell Factor ◽  
Host Cell Factor 1

scholarly journals Rapid Recapitulation of Nonalcoholic Steatohepatitis upon Loss of Host Cell Factor 1 Function in Mouse Hepatocytes

2018 ◽  
Vol 39 (5) ◽  
Author(s):  
Shilpi Minocha ◽  
Dominic Villeneuve ◽  
Viviane Praz ◽  
Catherine Moret ◽  
Maykel Lopes ◽  
...  
Keyword(s):  
Host Cell ◽  
Nonalcoholic Steatohepatitis ◽  
Genetically Engineered ◽  
Mouse Development ◽  
Linked Gene ◽  
Nonalcoholic Fatty Liver ◽  
Host Cell Factor ◽  
Mouse Hepatocytes ◽  
And Function ◽  
Host Cell Factor 1

ABSTRACT Host cell factor 1 (HCF-1), encoded by the ubiquitously expressed X-linked gene Hcfc1, is an epigenetic coregulator important for mouse development and cell proliferation, including during liver regeneration. We used a hepatocyte-specific inducible Hcfc1 knockout allele (called Hcfc1hepKO) to induce HCF-1 loss in hepatocytes of hemizygous Hcfc1hepKO/Y males by 4 days. In heterozygous Hcfc1hepKO/+ females, owing to random X-chromosome inactivation, upon Hcfc1hepKO allele induction, a 50/50 mix of HCF-1-positive and -negative hepatocyte clusters is engineered. The livers with Hcfc1hepKO/Y hepatocytes displayed a 21- to 24-day terminal nonalcoholic fatty liver (NAFL), followed by nonalcoholic steatohepatitis (NASH) disease progression typical of severe NAFL disease (NAFLD). In contrast, in livers with heterozygous Hcfc1hepKO/+ hepatocytes, HCF-1-positive hepatocytes replaced HCF-1-negative hepatocytes and revealed only mild NAFL development. Loss of HCF-1 led to loss of PGC1α protein, probably owing to its destabilization, and deregulation of gene expression, particularly of genes involved in mitochondrial structure and function, likely explaining the severe Hcfc1hepKO/Y liver pathology. Thus, HCF-1 is essential for hepatocyte function, likely playing both transcriptional and nontranscriptional roles. These genetically engineered loss-of-HCF-1 mice can be used to study NASH as well as NAFLD resolution.

scholarly journals Host cell factor 1 inhibits SKN-1 to modulate oxidative stress responses in Caenorhabditis elegans

Aging Cell ◽  
2012 ◽  
Vol 11 (4) ◽  
pp. 717-721 ◽  
Author(s):  
Gizem Rizki ◽  
Colette Lafontaine Picard ◽  
Charles Pereyra ◽  
Siu Sylvia Lee
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
Host Cell ◽  
Stress Responses ◽  
Host Cell Factor ◽  
Host Cell Factor 1 ◽  
Oxidative Stress Responses
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